1. Immunology/Inflammation
  2. Interleukin Related
  3. Ac-YVAD-CHO

Ac-YVAD-CHO (Synonyms: L-709049)

Cat. No.: HY-120019
Handling Instructions

Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO can suppress the production of mature IL-lβ.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Ac-YVAD-CHO Chemical Structure

Ac-YVAD-CHO Chemical Structure

CAS No. : 143313-51-3

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Description

Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO can suppress the production of mature IL-lβ[1].

IC50 & Target

IL-1β

3 nM (Ki)

IL-1β

0.76 nM (Ki)

In Vitro

Ac-YVAD-CHO inhibits IL-1β in a dose-dependent manner, with mouse and human IC50 values of 2.5 and 0.7 μM. Ac-YVAD-CHO (0.01~100 μM) reduces the elevations of IL-lβ in the plasma and peritoneal fluid treated with LPS in a dose-related manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ac-YVAD-CHO (10 mg/kg; i.p.; 1 hour) is absorbed from the peritoneal cavity, as well as cleared from the blood rapidly[1].
Ac-YVAD-CHO (50 mg/kg; i.p.; 1 hour) drops precipitously to approximately 1 and 0.2 μM at 30 and 60 minutes after injection[1].
Ac-YVAD-CHO (30 mg/kg; i.p.; 6 hours) suppresses IL-1β levels[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD1 female mice
Dosage: 10 mg/kg (Pharmacokinetic Analysis)
Administration: I.p.; 1 hour
Result: Absorbed from the peritoneal cavity, as well as cleared from the blood rapidly.
Animal Model: CD1 female mice
Dosage: 50 mg/kg (Pharmacokinetic Analysis)
Administration: I.p.; 1 hour
Result: Dropped precipitously to approximately 1 and 0.2 μM at 30 and 60 minutes after injection.
Animal Model: P. acnes-sensitized mice
Dosage: 30 mg/kg
Administration: I.p.; 6 hours
Result: Suppressed IL-1β levels.
Molecular Weight

492.52

Formula

C₂₃H₃₂N₄O₈

CAS No.
Sequence Shortening

Ac-YVAD-CHO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Ac-YVAD-CHOL-709049L709049L 709049Interleukin RelatedILpotentreversiblespecifictetrapeptideinterleukin-lβconvertingenzymeInhibitorinhibitorinhibit

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Ac-YVAD-CHO
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HY-120019
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