2. Immunology/Inflammation
    Apoptosis
  3. Interleukin Related
    Apoptosis
    Caspase
  4. Ac-YVAD-CHO

Ac-YVAD-CHO  (Synonyms: L-709049)

Cat. No.: HY-120019
Handling Instructions

Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO is also a caspase-1 inhibitor. Ac-YVAD-CHO can suppress the production of mature IL-lβ.

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Ac-YVAD-CHO Chemical Structure

Ac-YVAD-CHO Chemical Structure

CAS No. : 143313-51-3

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Description

Ac-YVAD-CHO (L-709049) is a potent, reversible, specific tetrapeptide interleukin-lβ converting enzyme (ICE) inhibitor with mouse and human Ki values of 3.0 and 0.76 nM. Ac-YVAD-CHO is also a caspase-1 inhibitor. Ac-YVAD-CHO can suppress the production of mature IL-lβ[1][2][3].

IC50 & Target[1][3]

IL-1β

 

Caspase-1

 

In Vitro

Ac-YVAD-CHO inhibits mouse and human IL-1β with IC50 values of 2.5 and 0.7 μM respectively[1].
Ac-YVAD-CHO (0.01-100 μM) reduces the elevations of IL-lβ in the plasma and peritoneal fluid treated with LPS[1].
Ac-YVAD-CHO (15.6 μM) reduces NO-induced thymocyte apoptosis[3].
Ac-YVAD-CHO (15.6 μM, 12 h) inhibits NO-induced PARP cleavage in SNAP-treated thymocytes[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[3]

Cell Line: SNAP-treated thymocytes
Concentration: 15.6 μM
Incubation Time: 12 h
Result: Reduced PARP cleavage.
In Vivo

Ac-YVAD-CHO (30 mg/kg; i.p.; 6 hours) suppresses IL-1β levels in blood of P. acnes-sensitized mice[1].
Ac-YVAD-CHO (2-8 μg, intrastriatal infusion) attenuates Quinolinic acid (QA)-induced apoptosis in rat striatum[2].
Ac-YVAD-CHO (10 and 50 mg/kg; i.p.; 1 hour) is cleared from the blood rapidly, and drops precipitously to approximately 1 and 0.2 μM at 30 and 60 minutes after injection[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: P. acnes-sensitized mice[1]
Dosage: 50 mg/kg
Administration: I.p.;
Result: Suppressed IL-1β levels in blood.
Animal Model: Quinolinic acid-treated Rats[2]
Dosage: 2-8 μg
Administration: Intrastriatal infusion.
Result: Attenuated Quinolinic acid (QA)-induced increases in p53 and apoptosis in rat striatum.
Inhibited QA-induced increases in caspase-1 activity and p53 protein levels, with no effect on QA-induced IκB-α degradation, NF-κB or AP-1 activation.
Molecular Weight

492.52

Formula

C23H32N4O8
CAS No.
Sequence Shortening

Ac-YVAD-CHO
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Ac-YVAD-CHO143313-51-3L-709049L709049L 709049Interleukin RelatedApoptosisCaspaseILTetrapeptideInterleukin-lβconvertingenzymethymocyteQuinolinic acidInhibitorinhibitorinhibit

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