1. Immunology/Inflammation
    Apoptosis
  2. COX
    Caspase
  3. Fenbufen

Fenbufen (Synonyms: CL-82204)

Cat. No.: HY-B1138 Purity: 98.99%
Handling Instructions

Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with analgetic and antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor.

For research use only. We do not sell to patients.

Fenbufen Chemical Structure

Fenbufen Chemical Structure

CAS No. : 36330-85-5

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
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Description

Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with analgetic and antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor[1][2][3][4][5].

IC50 & Target[4][5]

COX-1

3.9 μM (IC50)

COX-2

8.1 μM (IC50)

Caspase-1

4.4 μM (IC50)

Caspase-3

1.2 μM (IC50)

Caspase-4

0.57 μM (IC50)

Caspase-5

0.87 μM (IC50)

Caspase-9

0.76 μM (IC50)

In Vitro

Fenbufen (100-500 μM) improves the viability of apoptotic THP-1 cells treated with 25 μM Nigericin (HY-127019)[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Fenbufenmay (1200 mg/kg; feed) does not cause gastric ulceration whilst inducing a near maximal inhibition of prostaglandin release in rats[6].
Fenbufenmay (1200 mg/kg; p.o.; diet; for 10 days) blocks the hypertrophy of the heart but not that of the skeletal muscles[6].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male hooded Lister rats[6]
Dosage: 1200 mg/kg
Administration: Oral administration, diet, for 10 days
Result: Significantly reduced Clenbuterol (2mg/kg)-induced hypertrophy of the heart.
Molecular Weight

254.28

Formula

C₁₆H₁₄O₃

CAS No.

36330-85-5

SMILES

O=C(O)CCC(C1=CC=C(C2=CC=CC=C2)C=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (196.63 mM; Need ultrasonic)

H2O : 0.67 mg/mL (2.63 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9327 mL 19.6634 mL 39.3267 mL
5 mM 0.7865 mL 3.9327 mL 7.8653 mL
10 mM 0.3933 mL 1.9663 mL 3.9327 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (9.83 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.83 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

FenbufenCL-82204CL82204CL 82204COXCaspaseCyclooxygenaseanalgeticantipyreticanti-inflammatoryantirheumaticosteoarthritisankylosing spondylitistendinitisInhibitorinhibitorinhibit

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Fenbufen
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HY-B1138
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