1. Membrane Transporter/Ion Channel
    Immunology/Inflammation
    Anti-infection
    Apoptosis
  2. Sodium Channel
    NOD-like Receptor (NLR)
    Bacterial
    Apoptosis
    Antibiotic
  3. Nigericin

Nigericin 

Cat. No.: HY-127019
Handling Instructions

Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes.Nigericin can be a NLRP3 activator that induces the release of IL-1β as a NALP3-dependent manner. Nigericin triggers eryptosis, an effect paralleled by ROS formation, and in part due to induction of oxidative stress. Nigericin triggers apoptosis.

For research use only. We do not sell to patients.

Nigericin Chemical Structure

Nigericin Chemical Structure

CAS No. : 28380-24-7

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Top Publications Citing Use of Products

    Nigericin purchased from MCE. Usage Cited in: J Cell Mol Med. 2020 Jun 10.

    LPS + Nigericin is used to induce pyroptosis as a positive control group.
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    Description

    Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes[1].Nigericin can be a NLRP3 activator that induces the release of IL-1β as a NALP3-dependent manner[2]. Nigericin triggers eryptosis, an effect paralleled by ROS formation, and in part due to induction of oxidative stress. Nigericin triggers apoptosis[3].

    IC50 & Target

    K+/H+ ionophore[1]

    Molecular Weight

    724.96

    Formula

    C₄₀H₆₈O₁₁

    CAS No.

    28380-24-7

    SMILES
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    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

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    Keywords:

    NigericinSodium ChannelNOD-like Receptor (NLR)BacterialApoptosisAntibioticNa channelsNa+ channelsInhibitorinhibitorinhibit

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    Cat. No.:
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