1. Membrane Transporter/Ion Channel
    Immunology/Inflammation
    Apoptosis
  2. Sodium Channel
    NOD-like Receptor (NLR)
    Apoptosis
  3. Nigericin

Nigericin 

Cat. No.: HY-127019
Handling Instructions

Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes.Nigericin can be a NLRP3 activator that induces the release of IL-1β as a NALP3-dependent manner. Nigericin triggers eryptosis, an effect paralleled by ROS formation, and in part due to induction of oxidative stress. Nigericin triggers apoptosis.

For research use only. We do not sell to patients.

Nigericin Chemical Structure

Nigericin Chemical Structure

CAS No. : 28380-24-7

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Description

Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes[1].Nigericin can be a NLRP3 activator that induces the release of IL-1β as a NALP3-dependent manner[2]. Nigericin triggers eryptosis, an effect paralleled by ROS formation, and in part due to induction of oxidative stress. Nigericin triggers apoptosis[3].

IC50 & Target

K+/H+ ionophore[1]

Molecular Weight

724.96

Formula

C₄₀H₆₈O₁₁

CAS No.

28380-24-7

SMILES
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Nigericin
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