1. Apoptosis
  2. Apoptosis
  3. Valinomycin

Valinomycin (Synonyms: NSC 122023)

Cat. No.: HY-N6693 Purity: >99.0%
Handling Instructions

Valinomycin (NSC 122023) is a cyclic depsipeptide antibiotic first isolated from Streptomyces fulvissimus, act as a potassium selective ionophore. Valinomycin (NSC 122023) inhibits lymphocyte proliferation by its effects on the cell membrane, and induces apoptosis in CHO cells. Valinomycin induces activation of PINK1 leading to Parkin Ser65 phosphorylation.

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Custom Peptide Synthesis

Valinomycin Chemical Structure

Valinomycin Chemical Structure

CAS No. : 2001-95-8

Size Price Stock
10 mM * 1 mL in DMSO USD 86 Ask For Quote & Lead Time
5 mg USD 50 Ask For Quote & Lead Time
10 mg USD 70 Ask For Quote & Lead Time

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Description

Valinomycin (NSC 122023) is a cyclic depsipeptide antibiotic first isolated from Streptomyces fulvissimus, act as a potassium selective ionophore. Valinomycin (NSC 122023) inhibits lymphocyte proliferation by its effects on the cell membrane, and induces apoptosis in CHO cells[1]. Valinomycin induces activation of PINK1 leading to Parkin Ser65 phosphorylation[2].

Molecular Weight

1111.32

Formula

C₅₄H₉₀N₆O₁₈

CAS No.

2001-95-8

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (44.99 mM; Need ultrasonic)

Ethanol : 50 mg/mL (44.99 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8998 mL 4.4992 mL 8.9983 mL
5 mM 0.1800 mL 0.8998 mL 1.7997 mL
10 mM 0.0900 mL 0.4499 mL 0.8998 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.25 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.25 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.25 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% EtOH    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.25 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >99.0%

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Keywords:

ValinomycinNSC 122023NSC122023NSC-122023ApoptosisInhibitorinhibitorinhibit

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Valinomycin
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HY-N6693
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