1. Anti-infection
    Apoptosis
    Autophagy
  2. Bacterial
    Apoptosis
    Antibiotic
    Autophagy
  3. Valinomycin

Valinomycin (Synonyms: NSC 122023)

Cat. No.: HY-N6693
Handling Instructions

Valinomycin (NSC 122023), a cyclic depsipeptide antibiotic, act as a potassium selective ionophore. Valinomycin (NSC 122023) inhibits lymphocyte proliferation by its effects on the cell membrane, and induces apoptosis in CHO cells. Valinomycin induces activation of PINK1 leading to Parkin Ser65 phosphorylation.

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Custom Peptide Synthesis

Valinomycin Chemical Structure

Valinomycin Chemical Structure

CAS No. : 2001-95-8

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 86 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 86 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 70 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Valinomycin (NSC 122023), a cyclic depsipeptide antibiotic, act as a potassium selective ionophore. Valinomycin (NSC 122023) inhibits lymphocyte proliferation by its effects on the cell membrane, and induces apoptosis in CHO cells[1]. Valinomycin induces activation of PINK1 leading to Parkin Ser65 phosphorylation[2].

Molecular Weight

1111.32

Formula

C₅₄H₉₀N₆O₁₈

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
-20°C 1 year
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (44.99 mM; Need ultrasonic)

Ethanol : 50 mg/mL (44.99 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8998 mL 4.4992 mL 8.9983 mL
5 mM 0.1800 mL 0.8998 mL 1.7997 mL
10 mM 0.0900 mL 0.4499 mL 0.8998 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.25 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.25 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.25 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% EtOH    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.25 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.05%

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  • Molarity Calculator

  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Keywords:

ValinomycinNSC 122023NSC122023NSC-122023BacterialApoptosisAntibioticAutophagyInhibitorinhibitorinhibit

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Valinomycin
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HY-N6693
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