1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Apamin

Apamin (Synonyms: Apamine)

Cat. No.: HY-P0256
Handling Instructions

Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca2+-activated K+ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity.

For research use only. We do not sell to patients.

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Apamin Chemical Structure

Apamin Chemical Structure

CAS No. : 24345-16-2

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Description

Apamin (Apamine) is an 18 amino acid peptide neurotoxin found in apitoxin (bee venom), is known as a specifically selective blocker of Ca2+-activated K+ (SK) channels and exhibits anti-inflammatory and anti-fibrotic activity[1].

IC50 & Target

K+ channel[1]

In Vitro

Apamin (0.5-2 µg/mL; 24 hours; HSC-T6 cells) treatment markedly reduces the expression of α-SMA in the TGF-β1-induced HSC-T6 cells. Apamin treatment abrogats the activation of p-Smad2/3 and Smad4 induced by TGF-β1[1].

Western Blot Analysis[1]

Cell Line: HSC-T6 cells
Concentration: 0.5 µg/mL, 1 µg/mL and 2 µg/mL
Incubation Time: 24 hours
Result: Markedly reduced the expression of α-SMA in the TGF-β1-induced HSC-T6 cells. Abrogated the activation of p-Smad2/3 and Smad4 induced by TGF-β1.
In Vivo

Apamin (0.1 mg/kg; intraperitoneal injection; twice a week; for 4 weeks; C57BL/6 male mice) treatment results in decreased liver injury and proinflammatory cytokine levels. Apamin suppresses the deposition of collagen, proliferation of BECs and expression of fibrogenic genes in the 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC)-fed mice[1].

Animal Model: 8-week-old C57BL/6 male mice (20-25 g) with DDC feeding[1]
Dosage: 0.1 mg/kg
Administration: Intraperitoneal injection; twice a week; for 4 weeks
Result: Resulted in decreased liver injury and proinflammatory cytokine levels. Suppressed the deposition of collagen, proliferation of BECs and expression of fibrogenic genes in the DDC-fed mice.
Molecular Weight

2027.34

Formula

C₇₉H₁₃₁N₃₁O₂₄S₄

CAS No.

24345-16-2

Sequence

Cys-Asn-Cys-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys-Ala-Arg-Arg-Cys-Gln-Gln-His-NH2 (Disulfide bridge: Cys1-Cys11;Cys3-Cys15)

Sequence Shortening

CNCKAPETALCARRCQQH-NH2 (Disulfide bridge: Cys1-Cys11;Cys3-Cys15)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

ApaminApaminePotassium ChannelKcsAInhibitorinhibitorinhibit

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