Iberiotoxin 

Iberiotoxin is a toxin isolated from Buthus tamulus scorpion venom. Iberiotoxin is a selective high conductance high conductance Ca²⁺-activated K⁺ channel inhibitor with a K_d of ~1 nM. Iberiotoxin does not block other types of voltage-dependent ion channels^[1][2][3].

Kd: 1 nM (Ca²⁺-activated K⁺ channel)^[1][3]

Iberiotoxin reversibly blocks Ca2+-activated K+ channel in excised membrane patches from bovine aortic smooth muscle. Iberiotoxin acts exclusively at the outer face of the channel and functions with IC₅₀ values of about 250 pM. Iberiotoxin is a partial inhibitor of ¹²⁵I-charybdotoxin binding in bovine aortic sarcolemmal membrane vesicles (Ki of 2₅₀ pM). Iberiotoxin functions as a noncompetitive inhibitor of charybdotoxin binding^[1].
Iberiotoxin treatment affects rat mesenchymal stem cells (rMSCs) migration in the absence of platelet lysate (PL) by inducing a decrease in cell migration suggesting that BK channels regulate rMSCs migration in basal conditions. 10 nM of Iberiotoxin abolishes the PL-induced migration effect on MSCs^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Male Wistar rats (6-7 weeks old) with chronic heart failure (CHF), Iberiotoxin (0.125 nmol/nl, 1.25 nmol/nl and 12.5 nmol/nl) is infused into paraventricular hypothalamic nucleus (PVN) by osmotic minipumps. After perfusion of Iberiotoxin by microinjection of rAAV2-KCNMB4 shRNA virus, right ventricular weight/body weight and lung weight/body weight ratio as well as left ventricular end-diastolic diameter are increased and left ventricular ejection fraction is decreased^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

4230.85

C₁₇₉H₂₇₄N₅₀O₅₅S₇

129203-60-7

Solid

White to off-white

O=C([C@@H](NC([C@@H](N1)CCC1=O)=O)CC2=CC=CC=C2)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H]3CCCCN)=O)=O)CCCNC(N)=N)=O)CC(O)=O)=O)C(C)C)=O)=O)CC4=CC=CC=C4)=O)CC(C)C)=O)CC(O)=O)=O)CCCCN)=O)CSSC[C@@H](C(N[C@H](C(N[C@H](C(O)=O)CCC(N)=O)=O)CC5=CC=C(O)C=C5)=O)NC6=O)=O)C(C)C)=O)CO)=O)CC7=CNC8=CC=CC=C78)=O)CSSC[C@@H](C(N[C@H]6CCCNC(N)=N)=O)NC9=O)=O)CCC(O)=O)=O)CCCCN)=O)CO)=O)C(C)C)=O)CO)=O)CSSC[C@@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H]9CCCCN)=O)CCCCN)=O)=O)CCSC)=O)NC3=O)=O)CC(O)=O)=O)C(C)C)=O)CC(O)=O)=O)[C@@H](C)O

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)