129203-60-7
Chemical Structure
Iberiotoxin
- CAS No.: 129203-60-7
- Formula:C179H274N50O55S7
- Molecular Weight:4230.85
SMILES: O=C([C@@H](NC([C@@H](N1)CCC1=O)=O)CC2=CC=CC=C2)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H]3CCCCN)=O)=O)CCCNC(N)=N)=O)CC(O)=O)=O)C(C)C)=O)=O)CC4=CC=CC=C4)=O)CC(C)C)=O)CC(O)=O)=O)CCCCN)=O)CSSC[C@@H](C(N[C@H](C(N[C@H](C(O)=O)CCC(N)=O)=O)CC5=CC=C(O)C=C5)=O)NC6=O)=O)C(C)C)=O)CO)=O)CC7=CNC8=CC=CC=C78)=O)CSSC[C@@H](C(N[C@H]6CCCNC(N)=N)=O)NC9=O)=O)CCC(O)=O)=O)CCCCN)=O)CO)=O)C(C)C)=O)CO)=O)CSSC[C@@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H]9CCCCN)=O)CCCCN)=O)=O)CCSC)=O)NC3=O)=O)CC(O)=O)=O)C(C)C)=O)CC(O)=O)=O)[C@@H](C)O
Biological Activity: Iberiotoxin is a toxin isolated from Buthus tamulus scorpion venom. Iberiotoxin is a selective high conductance high conductance Ca2+-activated K+ channel inhibitor with a Kd of ~1 nM. Iberiotoxin does not block other types of voltage-dependent ion channels[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Iberiotoxin | 98.68% | Iberiotoxin is a toxin isolated from Buthus tamulus scorpion venom. Iberiotoxin is a selective high conductance high conductance Ca2+-activated K+ channel inhibitor with a Kd of ~1 nM. Iberiotoxin does not block other types of voltage-dependent ion channels. | ||||||||||||||||||||
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References
- [1]. A Galvez, et al. Purification and Characterization of a Unique, Potent, Peptidyl Probe for the High Conductance Calcium-Activated Potassium Channel From Venom of the Scorpion Buthus Tamulus. J Biol Chem. 1990 Jul 5;265(19):11083-90. [Content Brief]
- [2]. Santiago Echeverry, et al. Activation of BK Channel Contributes to PL-Induced Mesenchymal Stem Cell Migration. Front Physiol. 2020 Mar 24;11:210. [Content Brief]
- [3]. S Candia, et al. Mode of Action of Iberiotoxin, a Potent Blocker of the Large Conductance Ca(2+)-activated K+ Channel. Biophys J. 1992 Aug;63(2):583-90. [Content Brief]
