2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Hainantoxin-IV

Hainantoxin-IV is a specific antagonist of Sodium Channel, targeting to tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels. His28 and Lys32 are the key resiudes of Hainantoxin-IV for binding with target, while Hainantoxin-IV adopts an inhibitor cystine knot motif.

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Hainantoxin-IV

Hainantoxin-IV Chemical Structure

CAS No. : 651782-02-4

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Hainantoxin-IV Related Antibodies

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Description

Hainantoxin-IV is a specific antagonist of Sodium Channel, targeting to tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels. His28 and Lys32 are the key resiudes of Hainantoxin-IV for binding with target, while Hainantoxin-IV adopts an inhibitor cystine knot motif[1].

Molecular Weight

3987.53

Formula

C166H257N53O50S6
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Glu-Cys-Leu-Gly-Phe-Gly-Lys-Gly-Cys-Asn-Pro-Ser-Asn-Asp-Gln-Cys-Cys-Lys-Ser-Ser-Asn-Leu-Val-Cys-Ser-Arg-Lys-His-Arg-Trp-Cys-Lys-Tyr-Glu-Ile-NH2 (Disulfide bridge: Cys2-Cys17; Cys9-Cys24; Cys16-Cys31)
Sequence Shortening

ECLGFGKGCNPSNDQCCKSSNLVCSRKHRWCKYEI-NH2 (Disulfide bridge: Cys2-Cys17; Cys9-Cys24; Cys16-Cys31)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 1 mg/mL (0.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

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Purity & Documentation
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Hainantoxin-IV Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hainantoxin-IV651782-02-4HNTX-IVSodium ChannelNa channelsNa+ channelstetrodotoxin-sensitiveTTX-Svoltage-gated sodium channelscystine knot motifInhibitorinhibitorinhibit

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