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FCCP

(Synonyms: Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone)
117 Cited Publications
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Based on 117 publication(s) in Google Scholar

FCCP is an uncoupler of oxidative phosphorylation (OXPHOS) in mitochondria. FCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation.

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  • Pureté: 99.69%
  • CAS No.: 370-86-5
  • Formule: C10H5F3N4O
  • Masse moléculaire:254.17
  • Stockage:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • FCCP Chemical Structure
    FCCP Chemical Structure
  • Experimental Validation Results for FCCP
  • Experimental Validation Results for FCCP
  • Experimental Validation Results for FCCP
  • Experimental Validation Results for FCCP
  • Experimental Validation Results for FCCP
  • Experimental Validation Results for FCCP
CAS No.: 370-86-5
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Bio/Physico-chemical AssayCell Imaging/StainingFlow CytometryIFWBCell Proliferation/Viability Assay
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  • Cell Proliferation/Viability Assay
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  • FCCP Chemical Structure
    FCCP Chemical Structure
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    FCCP purchased from MedChemExpress. Usage Cited in: Nature. 2025 Mar;639(8055):765-775. [Abstract]

    Customer Validation
     OCR of neuroendocrine (n=4) and non-neuroendocrine (n=2) SCLC cell lines after FCCP (1.5 μM, 40 min) treatment (n=6 technical replicates for each cell line).

  • 1/16

    FCCP purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jul 30;16(1):6996. [Abstract]

    Customer Validation
     The mitophagy index of shRNA- or non-transduced 528NS and HOG-GSCs treated for 3 days with or without MitoTEMPOL (100 nM) on day 4 after shRNA transduction. FCCP (30 μM) and RA were used as positive controls.

  • 1/16

    FCCP purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 Aug 28;12(1):49. [Abstract]

    Customer Validation
     Immunofluorescence staining to show the CTSK expression level in osteoclasts that were treated with oligomycin A (10 nmol/L), rotenone (100 nmol/L), FCCP (1 μmol/L), 2DG (1 μmol/L) or 3BrPA (1 μmol/L) for 6 h (scale bar, 100 µm).

  • 1/16

    FCCP purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 Aug 28;12(1):49. [Abstract]

    Customer Validation
     Immunoblots of the pre-proenzyme and active CTSK levels in osteoclasts treated with 2DG (1 μmol/L), FCCP (1 μmol/L), rotenone (100 nmol/L) or 3-BrPA (1 μmol/L) for 10 h. The MMP-9 and CTSB expression levels were also detected. DMSO-treated osteoclasts were used as controls.

  • 1/16

    FCCP purchased from MedChemExpress. Usage Cited in: Cancer Res. 2023 Dec 15;83(24):4063-4079. [Abstract]

    Customer Validation
     Viability of Glut5-overexpressing and control cells cultured for 24 hours under different conditions in the presence of Rotenone or FCCP (10 μmol/L).

  • 1/16

    FCCP purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 May 13;13(1):2673. [Abstract]

    Customer Validation
     Flow cytometry analysis of WT and Myo19 KO cells stained with 100 nM TMRM for 20 min. 5 μM FCCP treatment for 10 min was used as positive.

  • FCCP