1. Anti-infection
  2. Bacterial

Gramicidin 

Cat. No.: HY-P0163
Handling Instructions

Gramicidin is an antimicrobial peptide assembling as channels in membranes and increasing their permeability towards cations.

For research use only. We do not sell to patients.

Gramicidin Chemical Structure

Gramicidin Chemical Structure

CAS No. : 1405-97-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
50 mg USD 50 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Gramicidin is an antimicrobial peptide assembling as channels in membranes and increasing their permeability towards cations.

IC50 & Target

Bacterial[1]

In Vitro

Gramicidin is an antimicrobial peptide assembling as channels in membranes and increasing their permeability towards cations. There is poor Gramicidin activity against E. coli and S. cerevisae as shown from the survival of microbes (%) over a range of Gramicidin concentrations, in contrast with the action of Gramicidin on S. aureus. The microbicidal activity occurs over a range of low Gramicidin and DODAB concentrations which are not toxic to S. cerevisae[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (53.13 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5313 mL 2.6563 mL 5.3126 mL
5 mM 0.1063 mL 0.5313 mL 1.0625 mL
10 mM 0.0531 mL 0.2656 mL 0.5313 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (1.33 mM); Clear solution

References
Cell Assay
[1]

Microbes and dispersions are mixed and interacted for one hour before being diluted up to 20,000-fold for plating of 0.1 mL of each in triplicate and incubation (24 hours for 37°C) for CFU counting. Cell survival (%), taken as the mean±standard deviation, is plotted against DODAB and/or Gramicidin concentration. As a control for cell viability in the absence of DODAB or DODAB/Gramicidin dispersions, a standard bacterial suspension is added to 0.264 M D-glucose solution, diluted, and spreaded on the agar plate[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

1882.30

Formula

C₉₉H₁₄₀N₂₀O₁₇

CAS No.

1405-97-6

SMILES

[Gramicidin]

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Gramicidin
Cat. No.:
HY-P0163
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Gramicidin

Cat. No.: HY-P0163