2. Disease Areas
  3. Infection
  4. Bacterial Infection
  5. Staphylococcus Aureus Infection

Staphylococcus Aureus Infection

Immunodeficiency-107 (IMD107) is an autosomal dominant disorder caused by heterozygous OTULIN mutations, leading to susceptibility to severe, life-threatening invasive Staphylococcus aureus infections primarily affecting the skin and lungs. The condition exhibits incomplete penetrance and variable expressivity, with normal immune cell counts and function; however, fibroblasts and other nonhematopoietic barrier cells display increased vulnerability to S. aureus alpha-toxin, indicating a primary defect in structural or barrier tissues rather than immune cells.

Staphylococcus Aureus Infection (201):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0565
    Doxycycline 564-25-0 98.20%
    Doxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor. Doxycycline shows antibacterial activity and anti-cancer cell proliferation activity.
    Doxycycline
  • HY-N0565B
    Doxycycline hyclate 24390-14-5 99.19%
    Doxycycline hyclate, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor. Doxycycline hyclate shows antibacterial activity and anti-cancer cell proliferation activity. Doxycycline hyclate can be used to construct gene expression regulation models.
    Doxycycline hyclate
  • HY-P9926
    Dupilumab 1190264-60-8 ≥99.2%
    Dupilumab (REGN-668) is a fully human mAb to IL-4 receptor α (IL-4Rα) that inhibits both IL-4 and IL-13 signaling, markedly improved moderate-to-severe atopic dermatitis.
    Dupilumab
  • HY-B0671
    Vancomycin 1404-90-6 99.39%
    Vancomycin is an antibiotic for the treatment of bacterial infections.
    Vancomycin
  • HY-A0276
    Gentamicin sulfate 1405-41-0
    Gentamicin sulfate, an aminoglycoside antibiotic, inhibits the growth of both gram-positive and gram-negative bacteria and to inhibit several strains of mycoplasma in tissue culture. Gentamicin sulfate inhibits DNase I with an IC50 of 0.57 mM.
    Gentamicin sulfate
  • HY-186109
    ZY39 2999673-51-5 99.73%
    ZY39 is a SaClpP agonist. ZY39 promotes the enzymatic hydrolysis of SaClpP and HsClpP in vitro. ZY39 inhibits the growth of Staphylococcus aureus strains. ZY39 reduces the load of Staphylococcus aureus in organs and ascites in mouse peritonitis models and zebrafish infection models, and improves the survival rate of model animals. ZY39 can be used in studies related to Staphylococcus aureus infection, such as peritonitis.
    ZY39
  • HY-P11187A
    Bactofencin A acetate 99.26%
    Bactofencin A acetate is a class IId bacteriocin and Antibacterial agent. Bactofencin A acetate is produced by Lactobacillus salivarius DPC6502, an isolate derived from the intestine. Bactofencin A acetate exhibits activity against Staphylococcus and Listeria species. Bactofencin A acetate slightly modulates the intestinal flora. Bactofencin A acetate can be used in research related to staphylococcal infections, listerial infections, and mastitis.
    Bactofencin A acetate
  • HY-137502A
    ML267 free base 1542213-03-5 98.45%
    ML267 free base is a blood-brain barrier permeable Antibacterial agent and bacterial phosphopantetheinyl transferase (PPTase) inhibitor, with an IC50 of 0.29 μM against Bacillus subtilis Sfp-PPTase and an IC50 of 8.1 μM against bacterial AcpS-PPTase. ML267 free base attenuates bacterial secondary metabolism, activity, and the production of Sfp-PPTase-dependent metabolites. ML267 free base inhibits the growth of Gram-positive bacteria, including Methicillin (HY-121544)-resistant Staphylococcus aureus. ML267 free base is applicable to research related to bacterial infections, including methicillin-resistant Staphylococcus aureus infections.
    ML267 free base
  • HY-N0565A
    Doxycycline hydrochloride 10592-13-9 99.99%
    Doxycycline hydrochloride, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor. Doxycycline hydrochloride shows antibacterial activity and anti-cancer cell proliferation activity. Doxycycline hydrochloride can be used to construct gene expression regulation models.
    Doxycycline hydrochloride
  • HY-Y0406E
    Calcium chloride anhydrous, for cell culture 10043-52-4 98.20%
    Calcium chloride anhydrous, for cell culture is an inorganic salt for the preparation of various buffers. Calcium chloride anhydrous, for cell culture can be used for animal modeling, to construct abdominal aortic aneurysm models.
    Calcium chloride anhydrous, for cell culture
  • HY-B0330
    Levofloxacin 100986-85-4 99.92%
    Levofloxacin ((-)-Ofloxacin) is an orally active antibiotic and is active against both Gram-positive and Gram-negative bacteria. Levofloxacin inhibits the DNA gyrase and topoisomerase IV. Levofloxacin can be used for chronic periodontitis, airway inflammation and BK Viremia research. Levofloxacin shows anti-orthopoxvirus activity.
    Levofloxacin
  • HY-B0108
    Daptomycin 103060-53-3 99.90%
    Daptomycin is a lipopeptide antibiotic with rapid in vitro bactericidal activity against gram-positive organisms.
    Daptomycin
  • HY-A0276A
    Gentamicin 1403-66-3
    Gentamicin, an aminoglycoside antibiotic, inhibits the growth of both gram-positive and gram-negative bacteria and to inhibit several strains of mycoplasma in tissue culture. Gentamicin inhibits DNase I with an IC50 of 0.57 mM.
    Gentamicin
  • HY-B0356A
    Ciprofloxacin monohydrochloride 93107-08-5 99.90%
    Ciprofloxacin (Bay-09867) monohydrochloride is an orally active, blood-brain barrier permeable fluoroquinolone antibacterial agent. Ciprofloxacin monohydrochloride exerts bactericidal effects primarily by inhibiting topoisomerase II and IV. Ciprofloxacin monohydrochloride inhibits the proliferation of human dental pulp stem cells and chondrocytes from young rats, and also activates the Akt signaling pathway and upregulates markers such as β-catenin and Nanog to maintain the morphological characteristics of stem cells. Ciprofloxacin monohydrochloride induces significant neurotoxicity and tissue damage, including reducing serotonin and glutathione levels in the brain, inducing oxidative stress and depression-like behaviors, and causing articular cartilage damage. Ciprofloxacin monohydrochloride can be applied to research related to infections of necrotic young permanent teeth and neurotoxicity.
    Ciprofloxacin monohydrochloride
  • HY-W016420
    Fosfomycin sodium 26016-99-9 99.95%
    Fosfomycin (MK-0955) sodium is a blood-brain barrier penetrating, broad-spectrum antibiotic by irreversibly inhibiting an early stage in cell wall synthesis. Fosfomycin sodium shows both in vivo and in vitro activity against a wide range of bacteria, including multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria.
    Fosfomycin sodium
  • HY-17025
    Rifabutin 72559-06-9 99.15%
    Rifabutin (Ansamycin) is a semisynthetic ansamycin antibiotic with potent antimycobacterial properties. Rifabutin inhibits DNA-dependent RNA polymerase.
    Rifabutin
  • HY-B0356B
    Ciprofloxacin hydrochloride monohydrate 86393-32-0 99.88%
    Ciprofloxacin (Bay-09867) hydrochloride monohydrate is an orally active, blood-brain barrier permeable fluoroquinolone antibacterial agent. Ciprofloxacin hydrochloride monohydrate exerts bactericidal effects primarily by inhibiting topoisomerase II and IV. Ciprofloxacin hydrochloride monohydrate inhibits the proliferation of human dental pulp stem cells and chondrocytes from young rats, and also activates the Akt signaling pathway and upregulates markers such as β-catenin and Nanog to maintain the morphological characteristics of stem cells. Ciprofloxacin hydrochloride monohydrate induces significant neurotoxicity and tissue damage, including reducing serotonin and glutathione levels in the brain, inducing oxidative stress and depression-like behaviors, and causing articular cartilage damage. Ciprofloxacin hydrochloride monohydrate can be applied to research related to infections of necrotic young permanent teeth and neurotoxicity.
    Ciprofloxacin hydrochloride monohydrate
  • HY-B1248
    Chlorhexidine 55-56-1 99.60%
    Chlorhexidine is a orally active cationic antimicrobial agent that targets microbial cell membranes. Chlorhexidine binds to cell membrane phospholipids non-specifically, destroys membrane structure and induces leakage of cell contents. Chlorhexidine has broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Chlorhexidine can interfere with membrane permeability, cause protein precipitation and energy metabolism disorders, such as rapid inhibition of microbial growth and induction of cell death (necrosis or apoptosis).
    Chlorhexidine
  • HY-E70529
    Ribonucleoside vanadyl complexes
    Ribonucleoside vanadyl complexes are a class of potent RNase and Taq polymerase inhibitors. Ribonucleoside vanadyl complexes protect RNA during RNA isolation by inhibiting ribonucleases, and also reduce the viability of bacteria and eukaryotic cells by interfering with ribosomal subunit assembly. Ribonucleoside vanadyl complexes block PCR and reverse transcription reactions templated by viral nucleic acids and enhance the effects of antibiotics against Staphylococcus aureus, but do not directly inhibit protein synthesis. Ribonucleoside vanadyl complexes can be effectively removed by phenol-chloroform extraction, thus enabling subsequent PCR analysis. Ribonucleoside vanadyl complexes can be applied in research related to chronic hepatitis C (HCV) and Staphylococcus aureus infection.
    Ribonucleoside vanadyl complexes
  • HY-105049
    Ceftaroline 189345-04-8 98.53%
    T-91825 (PPI-0903M), an N-phosphono-type cephalosporin, is the active form of TAK-599. T-91825 is active against both gram-positive and gram-negative bacteria.
    Ceftaroline