1. Anti-infection
    Autophagy
  2. Bacterial
    Autophagy
    Antibiotic
  3. Vancomycin

Vancomycin 

Cat. No.: HY-B0671 Purity: 98.11%
COA Handling Instructions

Vancomycin is an antibiotic for the treatment of bacterial infections.

For research use only. We do not sell to patients.

Vancomycin Chemical Structure

Vancomycin Chemical Structure

CAS No. : 1404-90-6

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Customer Review

Based on 23 publication(s) in Google Scholar

Other Forms of Vancomycin:

Top Publications Citing Use of Products
  • Biological Activity

  • Protocol

  • Purity & Documentation

  • References

  • Customer Review

Description

Vancomycin is an antibiotic for the treatment of bacterial infections.

IC50 & Target

Glycopeptide

 

In Vitro

Vancomycin is a large glycopeptide compound with a molecular weight of 1450 Da[1]. Vancomycin is a unique glycopeptide structurally unrelated to any currently available antibiotic. It also has a unique mode of action inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin is active against a large number of species of Gram-positive bacteria, such as Staphylococcus aureus, Staph. epidermidis, Str. agalactiae, Str. bovis, Str. mutans, viridans streptococci, enterococci[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Vancomycin is administered intravenously, with a standard infusion time of at least 1 h, to minimize infusion-related adverse effects. Subjects with normal creatinine clearance, vancomycin has an α-distribution phase of 30 min to 1 h and a β-elimination half-life of 6-12 h. The volume of distribution is 0.4–1 L/kg. The binding of vancomycin to protein ranges from 10% to 50%. Factors that affect the overall activity of vancomycin include its tissue distribution, inoculum size, and protein-binding effects[1]. Vancomycin treatment of infected mice is associated with improved clinical, diarrhea, and histopathology scores and survival during treatment[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

1449.25

Formula

C66H75Cl2N9O24

CAS No.
SMILES

O[[email protected]@H]1[[email protected]@H](O[[email protected]@](O[[email protected]@H](C)[[email protected]]2O)([H])C[[email protected]@]2(N)C)[[email protected]@H](O[[email protected]](CO)[[email protected]]1O)OC3=C(OC4=CC=C([[email protected]]([[email protected]]5NC([[email protected]](NC)CC(C)C)=O)O)C=C4Cl)C=C([[email protected]](NC([[email protected]@H](NC5=O)CC(N)=O)=O)([H])C(N[[email protected]](C6=O)([H])C7=CC8=C(O)C=C7)=O)C=C3OC9=CC=C([[email protected]]([[email protected]](C(N[[email protected]@](C(O)=O)([H])C%10=C8C(O)=CC(O)=C%10)=O)([H])N6)O)C=C9Cl

Structure Classification
Source

Streptomyces orientalis.

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (86.25 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6900 mL 3.4501 mL 6.9001 mL
5 mM 0.1380 mL 0.6900 mL 1.3800 mL
10 mM 0.0690 mL 0.3450 mL 0.6900 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 4.17 mg/mL (2.88 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 4.17 mg/mL (2.88 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.11%

References
Animal Administration
[3]

Mice: One set of experiments is performed in which infected mice are treated with vancomycin (50 mg/kg) daily for 1, 2, 3, or 5 days and are observed for 21 days postinfection or with vancomycin (20 mg/kg) daily for either 5 or 10 days and monitoring for 15 days postinfection[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Vancomycin
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HY-B0671
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