1. Anti-infection
    Autophagy
  2. Bacterial
    Autophagy
    Antibiotic
  3. Vancomycin

Vancomycin 

Cat. No.: HY-B0671
Handling Instructions

Vancomycin is an antibiotic for the treatment of bacterial infections.

For research use only. We do not sell to patients.

Vancomycin Chemical Structure

Vancomycin Chemical Structure

CAS No. : 1404-90-6

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Description

Vancomycin is an antibiotic for the treatment of bacterial infections.

In Vitro

Vancomycin is a large glycopeptide compound with a molecular weight of 1450 Da[1]. Vancomycin is a unique glycopeptide structurally unrelated to any currently available antibiotic. It also has a unique mode of action inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin is active against a large number of species of Gram-positive bacteria, such as Staphylococcus aureus, Staph. epidermidis, Str. agalactiae, Str. bovis, Str. mutans, viridans streptococci, enterococci[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Vancomycin is administered intravenously, with a standard infusion time of at least 1 h, to minimize infusion-related adverse effects. Subjects with normal creatinine clearance, vancomycin has an α-distribution phase of 30 min to 1 h and a β-elimination half-life of 6-12 h. The volume of distribution is 0.4–1 L/kg. The binding of vancomycin to protein ranges from 10% to 50%. Factors that affect the overall activity of vancomycin include its tissue distribution, inoculum size, and protein-binding effects[1]. Vancomycin treatment of infected mice is associated with improved clinical, diarrhea, and histopathology scores and survival during treatment[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

1449.25

Formula

C₆₆H₇₅Cl₂N₉O₂₄

CAS No.
SMILES

O[[email protected]@H]1[[email protected]@H](O[[email protected]@](O[[email protected]@H](C)[[email protected]]2O)([H])C[[email protected]@]2(N)C)[[email protected]@H](O[[email protected]](CO)[[email protected]]1O)OC3=C(OC4=CC=C([[email protected]]([[email protected]]5NC([[email protected]](NC)CC(C)C)=O)O)C=C4Cl)C=C([[email protected]](NC([[email protected]@H](NC5=O)CC(N)=O)=O)([H])C(N[[email protected]](C6=O)([H])C7=CC8=C(O)C=C7)=O)C=C3OC9=CC=C([[email protected]]([[email protected]](C(N[[email protected]@](C(O)=O)([H])C%10=C8C(O)=CC(O)=C%10)=O)([H])N6)O)C=C9Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Animal Administration
[3]

Mice: One set of experiments is performed in which infected mice are treated with vancomycin (50 mg/kg) daily for 1, 2, 3, or 5 days and are observed for 21 days postinfection or with vancomycin (20 mg/kg) daily for either 5 or 10 days and monitoring for 15 days postinfection[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

VancomycinBacterialAutophagyAntibioticInhibitorinhibitorinhibit

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