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  3. Vancomycin


Cat. No.: HY-B0671 Purity: 99.76%
COA Handling Instructions

Vancomycin is an antibiotic for the treatment of bacterial infections.

For research use only. We do not sell to patients.

Vancomycin Chemical Structure

Vancomycin Chemical Structure

CAS No. : 1404-90-6

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Customer Review

Based on 38 publication(s) in Google Scholar

Other Forms of Vancomycin:

Top Publications Citing Use of Products

38 Publications Citing Use of MCE Vancomycin

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Vancomycin is an antibiotic for the treatment of bacterial infections.

IC50 & Target



In Vitro

Vancomycin is a large glycopeptide compound with a molecular weight of 1450 Da[1]. Vancomycin is a unique glycopeptide structurally unrelated to any currently available antibiotic. It also has a unique mode of action inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin is active against a large number of species of Gram-positive bacteria, such as Staphylococcus aureus, Staph. epidermidis, Str. agalactiae, Str. bovis, Str. mutans, viridans streptococci, enterococci[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Vancomycin can be used in animal modeling to construct animal kidney injury models.

Vancomycin is administered intravenously, with a standard infusion time of at least 1 h, to minimize infusion-related adverse effects. Subjects with normal creatinine clearance, vancomycin has an α-distribution phase of 30 min to 1 h and a β-elimination half-life of 6-12 h. The volume of distribution is 0.4–1 L/kg. The binding of vancomycin to protein ranges from 10% to 50%. Factors that affect the overall activity of vancomycin include its tissue distribution, inoculum size, and protein-binding effects[1]. Vancomycin treatment of infected mice is associated with improved clinical, diarrhea, and histopathology scores and survival during treatment[3].

Vancomycin is a classic kidney injury modeling agent that induces disease by inducing oxidative stress-related apoptosis in animals. Rats and mice are generally used as animal models[4][5].

Dose reference for vancomycin induction[4][5]:
(1) Model animal: C57BL/6J male mice (6-week)
VIKI: 400 mg/kg/day, i.p, 7 day
(2) Model animals: Male Sprague-Dawley (SD) rats (200-250 g)
VIKI: 400 mg/kg/day, i.p, 7 day

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J male mice[4]
Dosage: 400 mg/kg/day, 7 day
Administration: intraperitoneal injection (i.p.)
Result: Caused renal injury with a higher renal injury score and kidney index.
Induced cell apoptosis and kidney Cr, BUN, MDA, IL-1β, IL-6, TNF-α, and NF-κB increace.
Clinical Trial
Molecular Weight







White to off-white



Structure Classification
Initial Source

Streptomyces orientalis.


Room temperature in continental US; may vary elsewhere.


4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (86.25 mM; ultrasonic and warming and heat to 60°C)

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6900 mL 3.4501 mL 6.9001 mL
5 mM 0.1380 mL 0.6900 mL 1.3800 mL
10 mM 0.0690 mL 0.3450 mL 0.6900 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 4.17 mg/mL (2.88 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 4.17 mg/mL (2.88 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.76%

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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