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  2. Bacterial
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Vancomycin hydrochloride 

Cat. No.: HY-17362 Purity: >98.0%
Data Sheet SDS Handling Instructions

Vancomycin hydrochloride is an antibiotic for the treatment of bacterial infections.

For research use only. We do not sell to patients.
Vancomycin hydrochloride Chemical Structure

Vancomycin hydrochloride Chemical Structure

CAS No. : 1404-93-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $55 In-stock
250 mg $50 In-stock
1 g $60 In-stock
5 g   Get quote  
10 g   Get quote  

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Other Forms of Vancomycin hydrochloride:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Vancomycin hydrochloride is an antibiotic for the treatment of bacterial infections.

In Vitro

Vancomycin is a large glycopeptide compound with a molecular weight of 1450 Da[1]. Vancomycin is a unique glycopeptide structurally unrelated to any currently available antibiotic. It also has a unique mode of action inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin is active against a large number of species of Gram-positive bacteria, such as Staphylococcus aureus, Staph. epidermidis, Str. agalactiae, Str. bovis, Str. mutans, viridans streptococci, enterococci[2].

In Vivo

Vancomycin is administered intravenously, with a standard infusion time of at least 1 h, to minimize infusion-related adverse effects. Subjects with normal creatinine clearance, vancomycin has an α-distribution phase of 30 min to 1 h and a β-elimination half-life of 6-12 h. The volume of distribution is 0.4–1 L/kg. The binding of vancomycin to protein ranges from 10% to 50%. Factors that affect the overall activity of vancomycin include its tissue distribution, inoculum size, and protein-binding effects[1]. Vancomycin treatment of infected mice is associated with improved clinical, diarrhea, and histopathology scores and survival during treatment[3].

Clinical Trial
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References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 0.6731 mL 3.3654 mL 6.7307 mL
5 mM 0.1346 mL 0.6731 mL 1.3461 mL
10 mM 0.0673 mL 0.3365 mL 0.6731 mL
Please refer to the solubility information to select the appropriate solvent.
Animal Administration
[3]

Mouse: One set of experiments is performed in which infected mice are treated with vancomycin (50 mg/kg) daily for 1, 2, 3, or 5 days and are observed for 21 days postinfection or with vancomycin (20 mg/kg) daily for either 5 or 10 days and monitoring for 15 days postinfection[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

1485.72

Formula

C₆₆H₇₆Cl₃N₉O₂₄

CAS No.

1404-93-9

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 24 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
Vancomycin hydrochloride
Cat. No.:
HY-17362
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