1. Anti-infection
    Autophagy
  2. Bacterial
    Autophagy
    Antibiotic
  3. Vancomycin hydrochloride

Vancomycin hydrochloride 

Cat. No.: HY-17362 Purity: 99.66%
Handling Instructions

Vancomycin hydrochloride is an antibiotic for the treatment of bacterial infections. It acts by inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin also alters the permeability of the cell membrane and selectively inhibits ribonucleic acid synthesis.

For research use only. We do not sell to patients.

Vancomycin hydrochloride Chemical Structure

Vancomycin hydrochloride Chemical Structure

CAS No. : 1404-93-9

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
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Estimated Time of Arrival: December 31
1 g USD 72 In-stock
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5 g USD 190 In-stock
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Based on 4 publication(s) in Google Scholar

Other Forms of Vancomycin hydrochloride:

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Description

Vancomycin hydrochloride is an antibiotic for the treatment of bacterial infections. It acts by inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin also alters the permeability of the cell membrane and selectively inhibits ribonucleic acid synthesis.

IC50 & Target

Bacterial[1]

In Vitro

Vancomycin is a large glycopeptide compound with a molecular weight of 1450 Da[1]. Vancomycin is a unique glycopeptide structurally unrelated to any currently available antibiotic. It also has a unique mode of action inhibiting the second stage of cell wall synthesis of susceptible bacteria. Vancomycin is active against a large number of species of Gram-positive bacteria, such as Staphylococcus aureus, Staph. epidermidis, Str. agalactiae, Str. bovis, Str. mutans, viridans streptococci, enterococci[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Vancomycin is administered intravenously, with a standard infusion time of at least 1 h, to minimize infusion-related adverse effects. Subjects with normal creatinine clearance, vancomycin has an α-distribution phase of 30 min to 1 h and a β-elimination half-life of 6-12 h. The volume of distribution is 0.4–1 L/kg. The binding of vancomycin to protein ranges from 10% to 50%. Factors that affect the overall activity of vancomycin include its tissue distribution, inoculum size, and protein-binding effects[1]. Vancomycin treatment of infected mice is associated with improved clinical, diarrhea, and histopathology scores and survival during treatment[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

1485.71

Formula

C₆₆H₇₆Cl₃N₉O₂₄

CAS No.

1404-93-9

SMILES

ClC1=CC([[email protected]]([[email protected]@H](NC([[email protected]](NC)CC(C)C)=O)C(N[[email protected]@H](CC(N)=O)C(N[[email protected]@]2([H])C(N[[email protected]]3([H])C4=CC(C5=C(C=C(O)C=C5O)[[email protected]](C(O)=O)([H])NC([[email protected]](NC3=O)([H])[[email protected]](O)C6=CC=C7C(Cl)=C6)=O)=C(O)C=C4)=O)=O)=O)O)=CC=C1OC8=C(C(O7)=CC2=C8)O[[email protected]]9[[email protected]@H]([[email protected]]([[email protected]](O)[[email protected]@H](CO)O9)O)O[[email protected]@]%10([H])C[[email protected]](N)([[email protected]](O)[[email protected]](C)O%10)C.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 33.33 mg/mL (22.43 mM; Need ultrasonic)

DMSO : 24 mg/mL (16.15 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6731 mL 3.3654 mL 6.7308 mL
5 mM 0.1346 mL 0.6731 mL 1.3462 mL
10 mM 0.0673 mL 0.3365 mL 0.6731 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (1.40 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (1.40 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (1.40 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[3]

Mice: One set of experiments is performed in which infected mice are treated with vancomycin (50 mg/kg) daily for 1, 2, 3, or 5 days and are observed for 21 days postinfection or with vancomycin (20 mg/kg) daily for either 5 or 10 days and monitoring for 15 days postinfection[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 99.66%

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Keywords:

VancomycinBacterialAutophagyAntibioticInhibitorinhibitorinhibit

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Product Name:
Vancomycin hydrochloride
Cat. No.:
HY-17362
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