1. Metabolic Enzyme/Protease
  2. MMP
  3. Doxycycline

Doxycycline 

Cat. No.: HY-N0565
Handling Instructions

Doxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor.

For research use only. We do not sell to patients.

Doxycycline Chemical Structure

Doxycycline Chemical Structure

CAS No. : 564-25-0

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Top Publications Citing Use of Products

    Doxycycline purchased from MCE. Usage Cited in: Cancer Lett. 2016 Jun 28;376(1):188-96.

    Doxycycline inducible shRNA can effectivly knockdown the expression of AKT in HCC cells. Cells are treated with 100ng/mL Doxcycline and cultured for the indicated times.
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    Description

    Doxycycline, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor[1].

    In Vitro

    Doxycycline affects growth of glioma cells only under high concentrations[2].
    Doxycycline decreases MT-CO1 protein content with concentrations of 1 µg/mL and higher in SVG cells[2].

    Cell Proliferation Assay[2]

    Cell Line: LNT-229, G55, and U343 glioma cells
    Concentration: 0.01, 0.1, 1, or 10 µg/mL
    Incubation Time: 4 days
    Result: Affected growth of glioma cells only under high concentrations.

    Western Blot Analysis[2]

    Cell Line: SVG cells
    Concentration: 0.01, 0.1, 1, or 10 µg/mL
    Incubation Time: 24 hours
    Result: Decreaseed MT-CO1 protein content with concentrations of 1 µg/mL and higher.
    In Vivo

    Doxycycline (oral; 200 or 800 mg/kg/day; for 3 months) reduces active MMP-9 in untreated HT mice in a dose-dependent manner[1].

    Animal Model: 6-month-old female Heterozygous Col3a1-deficient (HT) mice[1]
    Dosage: 200 or 800 mg/kg
    Administration: Oral; per day; for 3 months
    Result: Reduced active MMP-9 in a dose-dependent manner.
    Molecular Weight

    444.43

    Formula

    C₂₂H₂₄N₂O₈

    CAS No.

    564-25-0

    SMILES

    O=C(C(C1=O)=C(O)[[email protected]@H](N(C)C)[[email protected]]2([H])[[email protected]@H](O)[[email protected]]3([H])[[email protected]@H](C)C4=C(C(C3=C(O)[[email protected]@]21O)=O)C(O)=CC=C4)N

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    Room temperature in continental US; may vary elsewhere

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    References
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    Product Name:
    Doxycycline
    Cat. No.:
    HY-N0565
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