Doxycycline fosfatex
Based on 119 publication(s) in Google Scholar
Doxycycline fosfatex is an orally active highly lipophilic, tissue-permeable MMP inhibitor with broad-spectrum antibacterial activity. Doxycycline fosfatex is also a semi-synthetic antibiotic with chelating properties, which blocks bacterial protein synthesis and inhibits extracellular matrix degradation through interactions with zinc and calcium atoms. Doxycycline fosfatex also inhibits mitochondrial biogenesis, translation, and the expression of respiratory chain proteins. Doxycycline fosfatex induces apoptosis, inhibits autophagy and EMT, downregulates stem cell markers, and activates the PI3K-AKT pathway, thereby effectively inhibiting the viability and proliferation of cancer cells such as breast cancer cells. Doxycycline fosfatex also promotes the survival and self-renewal of embryonic stem cells and neural stem cells, and reduces the frequency of medium changes in culture. Doxycycline fosfatex has been applied in studies related to breast cancer, prostate cancer, bladder cancer, and other cancers.
For research use only. We do not sell to patients.
- CAS No.: 83038-87-3
- Formula: C22H24N2O8.1/3H4O12P4.1/3Na
- Molecular Weight:1675.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Publications Citing Use of MedChemExpress (MCE) Doxycycline fosfatex
More- Cell. 2026 Mar 5;189(5):1323-1340.e25. [Abstract]
- Cell. 2025 Jun 26;188(13):3405-3421.e27. [Abstract]
- Mol Cancer. 2020 Mar 30;19(1):68. [Abstract]
- Cancer Commun (Lond). 2025 May;45(5):608-631. [Abstract]
- Nat Genet. 2024 Feb;56(2):294-305. [Abstract]
- Nat Cell Biol. 2026 Apr;28(4):783-796. [Abstract]
- Cancer Res. 2025 Feb 1;85(3):585-601. [Abstract]
- Cancer Res. 2023 Oct 2;83(19):3220-3236. [Abstract]
- Drug Resist Updat. 2026 Jan:84:101319. [Abstract]
- Drug Resist Updat. 2024 Sep:76:101112. [Abstract]
- Nat Microbiol. 2023 Mar;8(3):410-423. [Abstract]
- Nat Protoc. 2025 Oct 8. [Abstract]
- Nat Commun. 2026 Apr 13;17(1):5061. [Abstract]
- Nat Commun. 2026 Apr 17;17(1):5369. [Abstract]
- Nat Commun. 2026 Feb 20;17(1):2963. [Abstract]
- Nat Commun. 2026 Jan 8;17(1):1253. [Abstract]
- Nat Commun. 2024 Apr 6;15(1):2989. [Abstract]
- Redox Biol. 2023 Jun:62:102686. [Abstract]
- Mol Cell. 2026 May 12:S1097-2765(26)00270-4. [Abstract]
- Mol Cell. 2025 Oct 2;85(19):3588-3604.e11. [Abstract]
- Mol Cell. 2025 Jul 17;85(14):2654-2672.e7. [Abstract]
- Nucleic Acids Res. 2026 Jun 8;54(11):gkag592. [Abstract]
- Theranostics. 2022 Mar 28;12(7):3131-3149. [Abstract]
- J Clin Invest. 2024 Jan 18;134(5):e171995. [Abstract]
- Adv Sci (Weinh). 2026 Apr;13(21):e18975. [Abstract]
- Adv Sci (Weinh). 2025 Oct 13:e09383. [Abstract]
- Adv Sci (Weinh). 2025 Sep;12(34):e03865. [Abstract]
- Adv Sci (Weinh). 2025 Mar;12(10):e2407942. [Abstract]
- Adv Sci (Weinh). 2021 Mar 15;8(10):2004344. [Abstract]
- Sci Adv. 2025 Jan 31;11(5):eadr8837. [Abstract]
- Sci Adv. 2022 Jan 28;8(4):eabl5220. [Abstract]
- Cell Death Differ. 2026 Apr 4. [Abstract]
- Cell Death Differ. 2025 Jul 5. [Abstract]
- Cell Death Differ. 2023 Jul;30(7):1811-1828. [Abstract]
- Water Res. 2023 Jul 15:240:120110. [Abstract]
- J Control Release. 2026 Feb 10:390:114586. [Abstract]
- Cell Death Dis. 2025 Mar 12;16(1):170. [Abstract]
- Cell Death Dis. 2022 Feb 10;13(2):138. [Abstract]
- Cell Death Dis. 2020 May 7;11(5):331. [Abstract]
- Cell Commun Signal. 2022 Apr 12;20(1):52. [Abstract]
- J Neuroinflammation. 2025 Oct 11;22(1):230. [Abstract]
- Phytomedicine. 2024 Nov:134:155958. [Abstract]
- Acta Pharmacol Sin. 2024 Nov;45(11):2420-2431. [Abstract]
- J Transl Med. 2024 Oct 10;22(1):923. [Abstract]
- Dev Cell. 2025 Apr 18:S1534-5807(25)00206-0. [Abstract]
- Oncogene. 2024 Dec;43(50):3660-3672. [Abstract]
- Oncogene. 2024 Feb;43(6):434-446. [Abstract]
- Apoptosis. 2026 Mar 11;31(3):98. [Abstract]
- NPJ Parkinsons Dis. 2022 Aug 6;8(1):100. [Abstract]
- Int J Mol Med. 2020 Apr;45(4):1187-1194. [Abstract]
- Stem Cell Res Ther. 2024 Oct 8;15(1):350. [Abstract]
- Cell Rep. 2026 Mar 20;45(4):117130. [Abstract]
- Cell Rep. 2025 Dec 5;44(12):116659. [Abstract]
- Cell Rep. 2025 May 26;44(6):115748. [Abstract]
- Cell Rep. 2024 Jul 3;43(7):114431. [Abstract]
- Cell Prolif. 2026 Apr 27:e70216. [Abstract]
- Cell Prolif. 2024 Feb;57(2):e13534. [Abstract]
- Emerg Microbes Infect. 2026 Dec;15(1):2686472. [Abstract]
- Fundam Res. 2025 Jul 8.
- Sci Signal. 2025 Mar 18;18(878):eadi5174. [Abstract]
- Emerg Microbes Infect. 2024 Dec;13(1):2321981. [Abstract]
- Virulence. 2026 Dec 31;17(1):2646808. [Abstract]
- JCI Insight. 2025 Dec 16:e193221. [Abstract]
- Biochem Pharmacol. 2025 Jul:237:116948. [Abstract]
- Cell Mol Life Sci. 2025 Apr 6;82(1):139. [Abstract]
- Cell Mol Life Sci. 2024 Nov 16;81(1):456. [Abstract]
- Inflammopharmacology. 2025 Apr;33(4):1935-1947. [Abstract]
- EMBO Rep. 2025 Oct 20. [Abstract]
- Cancer Biol Ther. 2022 Dec 31;23(1):328-335. [Abstract]
- Int J Mol Sci. 2026 Apr 9;27(8):3381. [Abstract]
- Int Immunopharmacol. 2026 Feb 1:170:116107. [Abstract]
- Int J Mol Sci. 2025 Mar 18;26(6):2712. [Abstract]
- Int Immunopharmacol. 2024 Sep 10:138:112518. [Abstract]
- Front Cell Infect Microbiol. 2021 Apr 28:11:640847. [Abstract]
- Biol Res. 2024 Nov 24;57(1):90. [Abstract]
- Molecules. 2025 Jul 7;30(13):2881. [Abstract]
- Molecules. 2023 Jul 26;28(15):5668. [Abstract]
- PLoS Pathog. 2026 Jan 30;22(1):e1013906. [Abstract]
- PLoS Pathog. 2025 Jul 3;21(7):e1013258. [Abstract]
- J Cell Mol Med. 2025 Sep;29(17):e70815. [Abstract]
- J Cell Mol Med. 2024 Sep;28(17):e70053. [Abstract]
- Virol Sin. 2022 Aug;37(4):558-568. [Abstract]
- Mol Oncol. 2024 Oct;18(10):2510-2523. [Abstract]
- ACS Infect Dis. 2024 Apr 12;10(4):1327-1338. [Abstract]
- iScience. 2023 Mar 16;26(4):106421. [Abstract]
- Ann Lab Med. 2021 May 1;41(3):293-301. [Abstract]
- FASEB J. 2024 Apr 30;38(8):e23628. [Abstract]
- FASEB J. 2020 Dec;34(12):16716-16735. [Abstract]
- Neurobiol Stress. 2025 Oct 28:39:100768. [Abstract]
- J Virol. 2026 May 14:e0003526. [Abstract]
- Microbiol Spectr. 2026 Mar 30;14(5):e0147325. [Abstract]
- Microbiol Spectr. 2025 Jul;13(7):e0307424. [Abstract]
- J Virol. 2024 Oct 22;98(10):e0133524. [Abstract]
- mSphere. 2026 Jun 30;11(6):e0031226. [Abstract]
- AMB Express. 2024 Dec 24;14(1):141. [Abstract]
- J Med Virol. 2025 May;97(5):e70356. [Abstract]
- J Med Virol. 2024 May;96(5):e29634. [Abstract]
- Water. 2025 Jun 6.
- Infect Drug Resist. 2026 May 8;19.
- Infect Drug Resist. 2025 Oct 4:18:5239-5247. [Abstract]
- Infect Drug Resist. 2025 Apr 23:18:2005-2020. [Abstract]
- Acta Histochem. 2026 Apr 27;128(3):152335. [Abstract]
- Vet Microbiol. 2024 May:292:110046. [Abstract]
- Clin Exp Pharmacol Physiol. 2023 Jul;50(7):604-609. [Abstract]
- Biochem Biophys Res Commun. 2022 Jul 30:615:163-171. [Abstract]
- Arch Oral Biol. 2026 May:185:106556. [Abstract]
- Diagn Microbiol Infect Dis. 2026 Feb;114(2):117181. [Abstract]
- bioRxiv. 2026 Jan 29:2026.01.28.702105. [Abstract]
- bioRxiv. 2025 August 09.
- bioRxiv. 2024 July 05.
- Heliyon. 2024 May 15;10(10):e31346. [Abstract]
- Res Sq. 2024 Apr 8:rs.3.rs-4013392. [Abstract]
- Research Square Preprint. 2024 Jan 23.
- Biomed Pharmacother. 2023 Aug:164:114998. [Abstract]
- Research Square Preprint. 2023 Jul 11.
- bioRxiv. 2023 Jun 14:2023.06.13.544756. [Abstract]
- bioRxiv. 2023 Mar 31:2023.03.29.534783. [Abstract]
- Charles University. 2020 Jul.
- Research Square Preprint. 2020 Jun.
Customer Validation & Images
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Biological Activity
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Tetracycline |
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Cell Line:LNT-229, G55, and U343 glioma cells
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Concentration:0.01, 0.1, 1 or 10 µg/mL
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Incubation Time:4 days
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Result:Affected growth of glioma cells only under high concentration (10 µg/mL).
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Cell Line:SVG cells
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Concentration:0.01, 0.1, 1 or 10 µg/mL
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Incubation Time:24 hours
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Result:Decreaseed MT-CO1 protein content with concentrations of 1 µg/mL and higher.
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Cell Line:MCF 12A, 293T cells
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Concentration:100 ng/mL, 1 µg/mL
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Incubation Time:96 hours
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Result:Caused reduced proliferation of MCF 12A and 293T cells at 1 µg/mL.
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Cell Line:MCF-7, MDA-MB-468 cells
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Concentration:0-250 μM
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Incubation Time:72 hours
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Result:Inhibited breast cancer cells in a dose-dependent manner with IC50 values for MCF-7 and MDA-MB-468 of 11.39 μM and 7.13 μM respectively.
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Animal Model:6-month-old female Heterozygous Col3a1-deficient (HT) mice[3]
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Dosage:200 or 800 mg/kg
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Administration:Oral gavage; 200 or 800 mg/kg; once daily; 3 months
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Result:Reduced active MMP-9 in a dose-dependent manner.
Chemical Information
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CAS No. 83038-87-3
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Molecular Weight 1675.31
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Formula C22H24N2O8.1/3H4O12P4.1/3Na
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SMILES
O[C@]12[C@]([C@H]([C@@]3([H])C(C(C4=C(O)C=CC=C4[C@@H]3C)=O)=C2O)O)([H])[C@@H](C(O)=C(C1=O)C(N)=O)N(C)C.O=P5(OP(O)(OP(O)(OP(O)(O5)=O)=O)=O)O.[Na].[1/3].[1/3]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (119)
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Journal Impact Factor
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Most Recent
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Cell
Sympathetic-epithelial crosstalk governs tissue-resident memory T cell immunosurveillance in the skin. [Abstract]2026 Mar 5;189(5):1323-1340.e25. PMID: 41616781 -
Cell
Extrachromosomal DNA replication and maintenance couple with DNA damage pathway in tumors. [Abstract]2025 Jun 26;188(13):3405-3421.e27. PMID: 40300601 -
Mol Cancer
Dying tumor cell-derived exosomal miR-194-5p potentiates survival and repopulation of tumor repopulating cells upon radiotherapy in pancreatic cancer. [Abstract]2020 Mar 30;19(1):68. PMID: 32228703 -
Cancer Commun (Lond)
Helicobacter pylori CagA elevates FTO to induce gastric cancer progression via a "hit-and-run" paradigm. [Abstract]2025 May;45(5):608-631. PMID: 39960839
Doxycycline fosfatex purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2025 May;45(5):608-631. [Abstract]
Bioluminescence imaging of the lung metastasis burden after inoculation of MKN45 cells with DOX (500 mg/kg, daily, 30 days)-induced CagA expression and MA treatment.
Doxycycline fosfatex purchased from MedChemExpress. Usage Cited in: Cancer Commun (Lond). 2025 May;45(5):608-631. [Abstract]
After inoculating MKN45 cells with DOX-induced CagA expression and MA treatment, HE staining was performed on lung tissue sections of a specified group. The quantitative results of the number of lung metastases are shown on the right.
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Nat Genet
Single-nucleus multi-omic profiling of human placental syncytiotrophoblasts identifies cellular trajectories during pregnancy. [Abstract]2024 Feb;56(2):294-305. PMID: 38267607
Doxycycline fosfatex purchased from MedChemExpress. Usage Cited in: Nat Genet. 2024 Feb;56(2):294-305. [Abstract]
RT-qPCR analysis of STAT5A and target gene expression in STB-BL with DOX (5 μM, 6 days)-inducible overexpression of STAT5A.
Doxycycline fosfatex purchased from MedChemExpress. Usage Cited in: Nat Genet. 2024 Feb;56(2):294-305. [Abstract]
RT-qPCR analysis of MITF and target gene expression in STB-BL with DOX (5 μM, 6 days)-inducible overexpression of MITF.
Doxycycline fosfatex purchased from MedChemExpress. Usage Cited in: Nat Genet. 2024 Feb;56(2):294-305. [Abstract]
ELISA analysis of CSH2 expression in trophoblast organoids derived from hTSCs-BL with DOX (5 μM, 6 days)-inducible overexpression of MITF.
Doxycycline fosfatex purchased from MedChemExpress. Usage Cited in: Nat Genet. 2024 Feb;56(2):294-305. [Abstract]
Bright fields and immunofluorescence analysis of trophoblast markers (CDH1 and hCG) in trophoblast organoids derived from hTSCs-BL with DOX (5 μM, 6 days)-inducible overexpression of MITF.
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Nat Cell Biol
Peritumoural adipose tissue promotes ferroptosis resistance by 3-hydroxykynurenine-mediated suppression of ferritinophagy. [Abstract]2026 Apr;28(4):783-796. PMID: 41813885 -
Cancer Res
Loss of CDKN2A Enhances the Efficacy of Immunotherapy in EGFR-Mutant Non-Small Cell Lung Cancer. [Abstract]2025 Feb 1;85(3):585-601. PMID: 39514336 -
Cancer Res
2023 Oct 2;83(19):3220-3236. PMID: 37463119 -
Drug Resist Updat
ZBP1 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in ovarian cancer. [Abstract]2026 Jan:84:101319. PMID: 41192279 -
Drug Resist Updat
Intercellular adhesion molecule-1 suppresses TMZ chemosensitivity in acquired TMZ-resistant gliomas by increasing assembly of ABCB1 on the membrane. [Abstract]2024 Sep:76:101112. PMID: 38924997 -
Nat Microbiol
Characterization of antibiotic resistomes by reprogrammed bacteriophage-enabled functional metagenomics in clinical strains. [Abstract]2023 Mar;8(3):410-423. PMID: 36759752 -
Nat Protoc
Inducible CRISPR-Cas9 screening platform to interrogate non-proliferative cellular states. [Abstract]2025 Oct 8. PMID: 41062702 -
Nat Commun
Intraovarian injection of securinine stimulates the growth of small ovarian follicles by reducing stromal suppression. [Abstract]2026 Apr 13;17(1):5061. PMID: 41974717 -
Nat Commun
ELMO2 is a therapeutic vulnerability in mesenchymal-like and drug-resistant non-small cell lung cancer. [Abstract]2026 Apr 17;17(1):5369. PMID: 41997974 -
Nat Commun
2026 Feb 20;17(1):2963. PMID: 41720774 -
Nat Commun
2026 Jan 8;17(1):1253. PMID: 41507162 -
Nat Commun
2024 Apr 6;15(1):2989. PMID: 38582902 -
Redox Biol
Targeting PKLR/MYCN/ROMO1 signaling suppresses neuroendocrine differentiation of castration-resistant prostate cancer. [Abstract]2023 Jun:62:102686. PMID: 36963289 -
Mol Cell
2026 May 12:S1097-2765(26)00270-4. PMID: 42127907 -
Mol Cell
2025 Oct 2;85(19):3588-3604.e11. PMID: 41043392 -
Mol Cell
Lactylation of XLF promotes non-homologous end-joining repair and chemoresistance in cancer. [Abstract]2025 Jul 17;85(14):2654-2672.e7. PMID: 40680721 -
Nucleic Acids Res
Enhancing small-molecule-mediated translational control through multivalent RNA aptamers. [Abstract]2026 Jun 8;54(11):gkag592. PMID: 42273917 -
Theranostics
Shh and Olig2 sequentially regulate oligodendrocyte differentiation from hiPSCs for the treatment of ischemic stroke. [Abstract]2022 Mar 28;12(7):3131-3149. PMID: 35547747 -
J Clin Invest
Targeting mitochondrial dynamics of morphine-responsive dopaminergic neurons ameliorates opiate withdrawal. [Abstract]2024 Jan 18;134(5):e171995. PMID: 38236644 -
Adv Sci (Weinh)
Targeting PRKCN, an Essential Driver Orchestrating mTOR-IRF4 Axis Independently of Kinase Activity, in Multiple Myeloma. [Abstract]2026 Apr;13(21):e18975. PMID: 41655233 -
Adv Sci (Weinh)
Faecalibaculum rodentium Alleviates Ionizing Radiation-Induced Damage in Mice by Improving Intestinal Integrity and Hematopoiesis via Its Metabolite Butyrate. [Abstract]2025 Oct 13:e09383. PMID: 41082369 -
Adv Sci (Weinh)
2025 Sep;12(34):e03865. PMID: 40525588 -
Adv Sci (Weinh)
HACD2 Promotes Pancreatic Cancer Progression by Enhancing PKM2 Dissociation From PRKN in a Dehydratase-Independent Manner. [Abstract]2025 Mar;12(10):e2407942. PMID: 39836601 -
Adv Sci (Weinh)
Dual Inhibition of DKC1 and MEK1/2 Synergistically Restrains the Growth of Colorectal Cancer Cells. [Abstract]2021 Mar 15;8(10):2004344. PMID: 34026451 -
Sci Adv
Epstein-Barr virus-driven cardiolipin synthesis sustains metabolic remodeling during B cell transformation. [Abstract]2025 Jan 31;11(5):eadr8837. PMID: 39879311 -
Sci Adv
2022 Jan 28;8(4):eabl5220. PMID: 35080973 -
Cell Death Differ
RIPK3 sequentially recruits MLKL and RIPK1 to induce PANoptosis and chemokine production. [Abstract]2026 Apr 4. PMID: 41935203 -
Cell Death Differ
The PLEKHA1-TACC2 fusion gene drives tumorigenesis via vascular mimicry formation in esophageal squamous-cell carcinoma. [Abstract]2025 Jul 5. PMID: 40615663 -
Cell Death Differ
2023 Jul;30(7):1811-1828. PMID: 37322264 -
Water Res
Quantifying community-wide antibiotic usage via urban water fingerprinting: Focus on contrasting resource settings in South Africa. [Abstract]2023 Jul 15:240:120110. PMID: 37247434 -
J Control Release
Hypoxia-responsive Azocalixarene-doxycycline host-guest complex for synergistic myopia control. [Abstract]2026 Feb 10:390:114586. PMID: 41475499 -
Cell Death Dis
Both direct and indirect suppression of MCL1 synergizes with BCLXL inhibition in preclinical models of gastric cancer. [Abstract]2025 Mar 12;16(1):170. PMID: 40075071 -
Cell Death Dis
Acquired temozolomide resistance in MGMTlow gliomas is associated with regulation of homologous recombination repair by ROCK2. [Abstract]2022 Feb 10;13(2):138. PMID: 35145081 -
Cell Death Dis
SOX1 promotes differentiation of nasopharyngeal carcinoma cells by activating retinoid metabolic pathway. [Abstract]2020 May 7;11(5):331. PMID: 32382038 -
Cell Commun Signal
Receptor activity-modifying protein 1 regulates mouse skin fibroblast proliferation via the Gαi3-PKA-CREB-YAP axis. [Abstract]2022 Apr 12;20(1):52. PMID: 35413847 -
J Neuroinflammation
MMPs and NETs are detrimental in CNS-tuberculosis with MMP Inhibition in CNS-tuberculosis mice improving survival. [Abstract]2025 Oct 11;22(1):230. PMID: 41076519 -
Phytomedicine
LW-213, a derivative of wogonin, triggers reticulophagy-mediated cell death in NSCLC via lysosomal damage combined with NPC1 inhibition. [Abstract]2024 Nov:134:155958. PMID: 39241385 -
Acta Pharmacol Sin
Chromosome instability functions as a potential therapeutic reference by enhancing chemosensitivity to BCL-XL inhibitors in colorectal carcinoma. [Abstract]2024 Nov;45(11):2420-2431. PMID: 39187678 -
J Transl Med
KLF14 directly downregulates the expression of GPX4 to exert antitumor effects by promoting ferroptosis in cervical cancer. [Abstract]2024 Oct 10;22(1):923. PMID: 39390559 -
Dev Cell
2025 Apr 18:S1534-5807(25)00206-0. PMID: 40280135 -
Oncogene
TMSB4Y restrains sphingomyelin synthesis via de novo purine synthesis to exert a tumor suppressor function in male esophageal squamous cell carcinoma. [Abstract]2024 Dec;43(50):3660-3672. PMID: 39443723 -
Oncogene
SOX10 deficiency-mediated LAMB3 upregulation determines the invasiveness of MAPKi-resistant melanoma. [Abstract]2024 Feb;43(6):434-446. PMID: 38102338 -
Apoptosis
2026 Mar 11;31(3):98. PMID: 41813919 -
NPJ Parkinsons Dis
Harmol promotes α-synuclein degradation and improves motor impairment in Parkinson's models via regulating autophagy-lysosome pathway. [Abstract]2022 Aug 6;8(1):100. PMID: 35933473 -
Int J Mol Med
Overexpression of IFIT2 inhibits the proliferation of chronic myeloid leukemia cells by regulating the BCR‑ABL/AKT/mTOR pathway. [Abstract]2020 Apr;45(4):1187-1194. PMID: 32124954 -
Stem Cell Res Ther
SMYD1 modulates the proliferation of multipotent cardiac progenitor cells derived from human pluripotent stem cells during myocardial differentiation through GSK3β/β-catenin&ERK signaling. [Abstract]2024 Oct 8;15(1):350. PMID: 39380045 -
Cell Rep
Autoinhibitory control of MLKL governs pseudokinase domain phosphorylation and oligomerization during necroptosis. [Abstract]2026 Mar 20;45(4):117130. PMID: 41863805 -
Cell Rep
circATF6 triggers calcium overload to synergize with EGFR-TKI in non-small cell lung cancer via modulation of proteostasis. [Abstract]2025 Dec 5;44(12):116659. PMID: 41351835 -
Cell Rep
A genome-wide base-editing screen uncovers a pivotal role of paxillin δ ubiquitination in influenza virus infection. [Abstract]2025 May 26;44(6):115748. PMID: 40434888 -
Cell Rep
Elevating PLK1 overcomes BETi resistance in prostate cancer via triggering BRD4 phosphorylation-dependent degradation in mitosis. [Abstract]2024 Jul 3;43(7):114431. PMID: 38968071 -
Cell Prolif
Dissection of Mitochondrial Function via Chemical Perturbation and Single-Cell Profiling. [Abstract]2026 Apr 27:e70216. PMID: 42044679 -
Cell Prolif
NELFA and BCL2 induce the 2C-like state in mouse embryonic stem cells in a chemically defined medium. [Abstract]2024 Feb;57(2):e13534. PMID: 37592709 -
Emerg Microbes Infect
Deep mutational scanning reveals the antibody escape and infectivity landscape of SARS-CoV-2 Omicron JN.1 and XEC receptor-binding domains. [Abstract]2026 Dec;15(1):2686472. PMID: 42324717 -
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Sci Signal
The kinase PLK1 promotes Hedgehog signaling-dependent resistance to the antiandrogen enzalutamide in metastatic prostate cancer. [Abstract]2025 Mar 18;18(878):eadi5174. PMID: 40100956 -
Emerg Microbes Infect
AMXT-1501 targets membrane phospholipids against Gram-positive and -negative multidrug-resistant bacteria. [Abstract]2024 Dec;13(1):2321981. PMID: 38422452 -
Virulence
Antibacterial efficacy and mechanism of the novel antimicrobial peptide lachnospirin-1 against Acinetobacter baumannii. [Abstract]2026 Dec 31;17(1):2646808. PMID: 41838520 -
JCI Insight
Therapeutic targeting of YOD1 disrupts the PAX-FOXO1-N-Myc feedback loop in rhabdomyosarcoma. [Abstract]2025 Dec 16:e193221. PMID: 41401084 -
Biochem Pharmacol
2025 Jul:237:116948. PMID: 40228640 -
Cell Mol Life Sci
Single-cell transcriptomics reveals liver developmental trajectory during lineage reprogramming of human induced hepatocyte-like cells. [Abstract]2025 Apr 6;82(1):139. PMID: 40188417 -
Cell Mol Life Sci
rTM reprograms macrophages via the HIF-1α/METTL3/PFKM axis to protect mice against sepsis. [Abstract]2024 Nov 16;81(1):456. PMID: 39549085 -
Inflammopharmacology
Casticin reduces rosacea-related inflammation by inhibiting mast cell activation via Mas-related G protein-coupled receptor X2. [Abstract]2025 Apr;33(4):1935-1947. PMID: 39821787 -
EMBO Rep
Tudor-based proteomic strategy pan-specifically enriches and identifies protein arginine methylation. [Abstract]2025 Oct 20. PMID: 41116072 -
Cancer Biol Ther
Curcumin activates NLRC4, AIM2, and IFI16 inflammasomes and induces pyroptosis by up-regulated ISG3 transcript factor in acute myeloid leukemia cell lines. [Abstract]2022 Dec 31;23(1):328-335. PMID: 35435150 -
Int J Mol Sci
A Clozapine-Responsive GPCR-Based Gene Switch for Pharmacological Control of Gene Expression in Mammalian Cells and In Vivo. [Abstract]2026 Apr 9;27(8):3381. PMID: 42074026 -
Int Immunopharmacol
2026 Feb 1:170:116107. PMID: 41455370 -
Int J Mol Sci
O-GlcNAcylation in Gli1+ Mesenchymal Stem Cells Is Indispensable for Bone Formation and Fracture Healing. [Abstract]2025 Mar 18;26(6):2712. PMID: 40141354 -
Int Immunopharmacol
Targeting lipid peroxidation-associated ferroptosis suppresses lung carcinoma progression by regulating cell cycle arrest. [Abstract]2024 Sep 10:138:112518. PMID: 38917528 -
Front Cell Infect Microbiol
Doxycycline Induces Apoptosis of Brucella Suis S2 Strain-Infected HMC3 Microglial Cells by Activating Calreticulin-Dependent JNK/p53 Signaling Pathway. [Abstract]2021 Apr 28:11:640847. PMID: 33996626 -
Biol Res
Perturbation of mammary epithelial cell apicobasal polarity by RHBDF1-facilitated nuclear translocation of PKCζ. [Abstract]2024 Nov 24;57(1):90. PMID: 39582014 -
Molecules
Urolithin A Attenuates Periodontitis in Mice via Dual Anti-Inflammatory and Osteoclastogenesis Inhibition: A Natural Metabolite-Based Therapeutic Strategy. [Abstract]2025 Jul 7;30(13):2881. PMID: 40649395 -
Molecules
Antibacterial Activity and Mechanism of Canagliflozin against Methicillin-Resistant Staphylococcus aureus. [Abstract]2023 Jul 26;28(15):5668. PMID: 37570637 -
PLoS Pathog
YAP Inhibits HIV-1 transcription and promotes HIV-1 latency by regulating E3 ubiquitin ligase UHRF1 mediated tat degradation. [Abstract]2026 Jan 30;22(1):e1013906. PMID: 41616025 -
PLoS Pathog
The non-structural protein of SFTSV activates NLRP1 and CARD8 inflammasome through disrupting the DPP9-mediated ternary complex. [Abstract]2025 Jul 3;21(7):e1013258. PMID: 40608794 -
J Cell Mol Med
Pharmacological Targeting of DHHC9-Mediated STRN4 Palmitoylation to Suppress YAP-Driven Cancer Metastasis. [Abstract]2025 Sep;29(17):e70815. PMID: 40903842 -
J Cell Mol Med
2024 Sep;28(17):e70053. PMID: 39224032 -
Virol Sin
Establishment and characterization of a new cell culture system for hepatitis B virus replication and infection. [Abstract]2022 Aug;37(4):558-568. PMID: 35568375 -
Mol Oncol
2024 Oct;18(10):2510-2523. PMID: 38775167 -
ACS Infect Dis
Lusutrombopag as a Repurposing Drug in Combination with Aminoglycosides against Vancomycin-Resistant Enterococcus. [Abstract]2024 Apr 12;10(4):1327-1338. PMID: 38567846 -
iScience
Hepatitis C virus hypervariable region 1 antibodies interrupt E2-SR-B1 interaction to suppress viral infection. [Abstract]2023 Mar 16;26(4):106421. PMID: 37034976 -
Ann Lab Med
In Vitro Activity of the Novel Tetracyclines, Tigecycline, Eravacycline, and Omadacycline, Against Moraxella catarrhalis. [Abstract]2021 May 1;41(3):293-301. PMID: 33303714 -
FASEB J
2024 Apr 30;38(8):e23628. PMID: 38661032 -
FASEB J
2020 Dec;34(12):16716-16735. PMID: 33124742 -
Neurobiol Stress
Electroacupuncture attenuates anxiety caused by chronic mild stress through inhibiting NOX2-derived oxidative stress in ventral hippocampus. [Abstract]2025 Oct 28:39:100768. PMID: 41280328 -
J Virol
Generation of HBV cccDNA using single-stranded M13 phage DNA for authentic minichromosome functionality. [Abstract]2026 May 14:e0003526. PMID: 42132423 -
Microbiol Spectr
Eravacycline for Mycobacterium abscessus infections: pharmacodynamic advantages of long-acting post-antibiotic effects and weekly dosing regimens. [Abstract]2026 Mar 30;14(5):e0147325. PMID: 41910138 -
Microbiol Spectr
Antimicrobial resistance of rapidly growing mycobacteria isolated from companion animals in Taiwan. [Abstract]2025 Jul;13(7):e0307424. PMID: 40387379 -
J Virol
2024 Oct 22;98(10):e0133524. PMID: 39212385 -
mSphere
Aloe emodin isolated from Cassiae semen upregulates IFITM1 to suppress hepatitis B virus replication via the interferon signaling pathway. [Abstract]2026 Jun 30;11(6):e0031226. PMID: 42274254 -
AMB Express
Repurposing pinaverium bromide against Staphylococcus and its biofilms with new mechanisms. [Abstract]2024 Dec 24;14(1):141. PMID: 39718732
Doxycycline fosfatex purchased from MedChemExpress. Usage Cited in: AMB Express. 2024 Dec 24;14(1):141. [Abstract]
Combinational antimicrobial effects between PVB and conventional antibiotics against MRSA ATCC 43,300. TET, Tetracycline. DOX, Doxycycline. E, Erythromycin. AZI, Azithromycin. P, Penicillin. CAZ, Ceftazidime. AMP, Ampicillin. CEZ, Cefazolin. CEF, Cefotaxime. OXA, Oxacillin. CRO, Ceftriaxone. AMK, Amikacin. GEN, Gentamycin, KANA, Kanamycin. TOB, Tobramycin. SPC, Spectinomycin.
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J Med Virol
Hepatitis B Virus Promotes Angiogenesis in Hepatocellular Carcinoma by Increasing m6A Modification of VEGFA mRNA via IGF2BP3. [Abstract]2025 May;97(5):e70356. PMID: 40260505 -
J Med Virol
Epstein-Barr virus-driven metabolic alterations contribute to the viral lytic reactivation and tumor progression in nasopharyngeal carcinoma. [Abstract]2024 May;96(5):e29634. PMID: 38682578 -
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Infect Drug Resist
In vitro Activity of the Novel Tetracyclines Derivative, Zifanocycline Against Mycobacterium abscessus. [Abstract]2025 Oct 4:18:5239-5247. PMID: 41069760 -
Infect Drug Resist
Doxycycline-Induced Apoptosis in Brucella suis S2-Infected HMC3 Cells via Calreticulin Suppression and Activation of the IRE1/Caspase-3 Signaling Pathway. [Abstract]2025 Apr 23:18:2005-2020. PMID: 40290405 -
Acta Histochem
YAP promotes wound healing in diabetic mice by improving endothelial cell function via the regulation of SEMA3B. [Abstract]2026 Apr 27;128(3):152335. PMID: 42048860 -
Vet Microbiol
Discovery of the tigecycline resistance gene cluster tmexCD3-toprJ1 in Pasteurella multocida strains isolated from pigs in China. [Abstract]2024 May:292:110046. PMID: 38471428 -
Clin Exp Pharmacol Physiol
In vitro susceptibility testing of tetracycline-class antibiotics against slowly growing non-tuberculous mycobacteria. [Abstract]2023 Jul;50(7):604-609. PMID: 37086075 -
Biochem Biophys Res Commun
Identification of mutant p53-specific proteins interaction network using TurboID-based proximity labeling. [Abstract]2022 Jul 30:615:163-171. PMID: 35665610 -
Arch Oral Biol
ATF5-mediated mitochondrial UPR inhibited RANKL in Porphyromonas gingivalis LPS-treated osteoblasts. [Abstract]2026 May:185:106556. PMID: 41759254 -
Diagn Microbiol Infect Dis
2026 Feb;114(2):117181. PMID: 41205476 -
bioRxiv
A HaloTag-4R-Tau Pulse-Chase Sensor Reveals Neddylation Inhibition Promotes Degradation of Tau in iNeurons. [Abstract]2026 Jan 29:2026.01.28.702105. PMID: 41659571 -
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Heliyon
Pancreatic cancer cells hijack tumor suppressive microRNA-26a to promote radioresistance and potentiate tumor repopulation. [Abstract]2024 May 15;10(10):e31346. PMID: 38807872 -
Res Sq
Epstein-Barr-Virus-Driven Cardiolipin Synthesis Sustains Metabolic Remodeling During B-cell Lymphomagenesis. [Abstract]2024 Apr 8:rs.3.rs-4013392. PMID: 38659762 -
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Biomed Pharmacother
Anti-photoaging effect and mechanism of flexible liposomes co-loaded with apigenin and doxycycline. [Abstract]2023 Aug:164:114998. PMID: 37301137 -
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bioRxiv
2023 Jun 14:2023.06.13.544756. PMID: 37398283 -
bioRxiv
2023 Mar 31:2023.03.29.534783. PMID: 37034813 -
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Purity & Documentation
References
[1]. El-Neweshy MS, et al. Experimental doxycycline overdose in rats causes cardiomyopathy. Int J Exp Pathol. 2013;94(2):109-114. [Content Brief]
[2]. Zhang L, et al. Doxycycline inhibits the cancer stem cell phenotype and epithelial-to-mesenchymal transition in breast cancer. Cell Cycle. 2017;16(8):737-745. [Content Brief]
[5]. Chang MY, et al. Doxycycline supplementation allows for the culture of human ESCs/iPSCs with media changes at 3-day intervals. Stem Cell Res. 2015;15(3):608-613. [Content Brief]
[6]. Manfredsson FP, et al. Tight Long-term dynamic doxycycline responsive nigrostriatal GDNF using a single rAAV vector. Mol Ther. 2009 Nov;17(11):1857-67. [Content Brief] [Content Brief]
[7]. Kistner A, et al. Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice. Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10933-8. [Content Brief]
[8]. Niv Y. Doxycycline in Eradication Therapy of Helicobacter pylori--a Systematic Review and Meta-Analysis. Digestion. 2016;93(2):167-73. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Doxycycline fosfatex Related Classifications
HY-N0565D Related Classifications
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