1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. MMP
  4. MMP Inhibitors

MMP Inhibitors

MMP-1

MMP-2

MMP-3

MMP-8

MMP-9

MMP-13

MMP-14

ADAM10

ADAM17

MMP-7

MMP-12

MMP-10

MMP

ADAM8

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

MMP Inducers, Inhibitors, Agonists & Activators
Product Name MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8 Purity
Ilomastat
Fibroblast collagenase, Ki: 0.4 nM (Human skin)
MMP-1, IC50: 1.5 nM
MMP-2, IC50: 1.1 nM
MMP-3, IC50: 1.9 nM
 
MMP-9, IC50: 0.5 nM
                  98.33%
Astragaloside IV  
MMP-2
   
MMP-9
                  ≥98.0%
PPNDS tetrasodium              
ADAM10, IC50: 1.2 μM
           
Chloramphenicol          
MMP13
                99.82%
Cordycepin
MMP-1
 
MMP-3
                      ≥99.0%
Marimastat
MMP-1, IC50: 5 nM
MMP-2, IC50: 6 nM
MMP-3, IC50: 3 nM
     
MMP-14, IC50: 9 nM
   
MMP-7, IC50: 13 nM
        ≥98.0%
SB-3CT  
MMP-2, Ki: 13.9 nM
   
MMP-9, Ki: 600 nM
                  99.35%
Salvianolic acid A        
MMP-9
                  99.75%
Meloxicam  
MMP-2
                        99.88%
TAPI-2                        
MMP, IC50: 20 μM
 
MMP-9-IN-1        
MMP-9
                  99.71%
Indinavir sulfate  
MMP-2
                        99.82%
Isofraxidin                  
MMP-7
        99.00%
Aderbasib              
ADAM10
ADAM17
          98.09%
Luteolin 7-O-glucuronide
MMP-1, IC50: 17.63 μM
 
MMP-3, IC50: 7.99 μM
MMP-8, IC50: 11.42 μM
MMP-9, IC50: 12.85 μM
MMP13, IC50: 0.03 μM
                99.80%
ARP-100
MMP-1, IC50: >50 μM
MMP-2, IC50: 12 nM
MMP-3, IC50: 4.5 μM
 
MMP-9, IC50: 0.2 μM
       
MMP-7, IC50: >50 μM
        ≥99.0%
FSL-1 TFA        
MMP-9
                  98.52%
Prinomastat hydrochloride
MMP-1, IC50: 79 nM
MMP-2, Ki: 0.05 nM
   
MMP-9, IC50: 5 nM
MMP-9, Ki: 0.26 nM
MMP-13, IC50: 6.3 nM
MMP-13, Ki: 0.3 nM
                ≥98.0%
UK 356618
MMP-1, IC50: 51 μM
MMP-2, IC50: 1.79 μM
MMP-3, IC50: 5.9 nM
 
MMP-9, IC50: 0.84 μM
MMP-13, IC50: 73 nM
MMP-14, IC50: 1.9 μM
              98.91%
GW280264X              
ADAM10, IC50: 11.5 nM
ADAM17, IC50: 8 nM
         
Apigenin-7-glucuronide    
MMP-3, IC50: 12.87 μM
MMP-8, IC50: 22.39 μM
MMP-9, IC50: 17.52 μM
MMP13, IC50: 0.27 μM
                98.83%
Morroniside  
MMP2
   
MMP9
                  98.55%
S 3304        
MMP-9
                  99.11%
PF-00356231 hydrochloride    
MMP-3, IC50: 0.39 μM
MMP-8, IC50: 1.7 μM
MMP-9, IC50: 0.98 μM
MMP13, IC50: 0.65 nM
       
MMP-12, IC50: 1.4 μM
      99.52%
Auraptene  
MMP-2
                        99.52%
Ginkgolide C        
MMP-9
                  ≥98.0%
Prinomastat
MMP-1, IC50: 79 nM
MMP-2, Ki: 0.05 nM
MMP-3, IC50: 6..3 nM
MMP-3, Ki: 0.3 nM
 
MMP-9, IC50: 5 nM
MMP-9, Ki: 0.26 nM
                  ≥98.0%
DB04760          
MMP-13, IC50: 8 nM
                98.45%
Isoliquiritin apioside        
MMP9
                  99.87%
Imidapril hydrochloride        
MMP-9
                  99.76%
XL-784
MMP-1, IC50: 1900 nM
MMP-2, IC50: 0.81 nM
MMP-3, IC50: 120 nM
MMP-8, IC50: 10.8 nM
MMP-9, IC50: 18 nM
MMP13, IC50: 0.56 nM
                98.13%
Cipemastat
collagenases 1, Ki: 3.0 nM
gelatinase A, Ki: 154 nM
stromelysins 1, Ki: 527 nM
collagenases 2, Ki: 4.4 nM
gelatinase B, Ki: 59.1 nM
collagenases 3, Ki: 3.4 nM
                99.49%
PD-166793
MMP-1, IC50: 6.0 μM
MMP-2, IC50: 4 nM
MMP-3, IC50: 7 nM
 
MMP-9, IC50: 7.9 μM
MMP-13, IC50: 8 nM
     
MMP-7, IC50: 7.2 μM
        ≥99.0%
β-Anhydroicaritin    
MMP-3
                      99.09%
Cynaropicrin          
MMP13
               
CMC2.24
MMP-1, IC50: 69.8 μM
MMP-2, IC50: 4.8 μM
MMP-3, IC50: 2.9 μM
MMP-8, IC50: 4.5 μM
MMP-9, IC50: 8 μM
MMP-13, IC50: 2.7 μM
MMP-14, IC50: 15.3 μM
   
MMP-7, IC50: 5 μM
MMP-12, IC50: 2 μM
     
UK-370106  
MMP-2, IC50: 34.2 μM
MMP-3, IC50: 23 nM
MMP-8, IC50: 1.75 μM
MMP-9, IC50: 30.4 μM
MMP-13, IC50: 2.3 μM
MMP-14, IC50: 66.9 μM
   
MMP-7, IC50: 5.8 μM
MMP-12, IC50: 42 nM
      ≥99.0%
CTTHWGFTLC, CYCLIC TFA  
MMP-2
   
MMP-9
                  98.60%
BI-4394  
MMP-2, IC50: 18 μM
   
MMP-9, IC50: 8.9 μM
MMP-13, IC50: 1 nM
MMP-14, IC50: 8.3 μM
       
MMP-10, IC50: 16 μM
    99.91%
MMP13-IN-2  
MMP-2, IC50: 180 nM
MMP-3, IC50: 1100 nM
   
MMP-13, IC50: 0.036 nM
                99.85%
Tanomastat  
MMP-2, Ki: 11 nM
MMP-3, Ki: 143 nM
 
MMP-9, Ki: 301 nM
MMP-13, Ki: 1470 nM
                ≥99.0%
MMPI-1154
MMP-1, IC50: 10 μM
MMP-2, IC50: 6.6 μM
   
MMP-9, IC50: 13 μM
MMP-13, IC50: 1.8 μM
                99.87%
YH-306  
MMP2
   
MMP9
                  98.01%
TMI-1                
ADAM17, IC50: 8.4 nM
          99.59%
ND-336  
MMP-2, Ki: 85 nM
   
MMP-9, Ki: 150 nM
 
MMP-14, Ki: 120 nM
             
Indinavir  
MMP-2
                       
Otaplimastat                        
MMP
  98.41%
FFAGLDD        
MMP9
                 
(R)-ND-336  
MMP-2, Ki: 127 nM
   
MMP-9, Ki: 19 nM
 
MMP-14, Ki: 119 nM
             
Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2            
MMP-14
             
Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2
MMP-1
 
MMP-3
                     
CP-471474
MMP-1, IC50: 1170 nM
MMP-2, IC50: 0.7 nM
MMP-3, IC50: 16 nM
 
MMP-9, IC50: 13 nM
MMP-13, IC50: 0.9 nM
               
MMP-9-IN-5
MMP-1, IC50: 104 nM
MMP-2, IC50: 266 nM
   
MMP-9, IC50: 4.49 nM
MMP-13, IC50: 280 nM
               
CP-544439
MMP-1, IC50: 420 nM
MMP-2, IC50: 1.6 nM
MMP-3, IC50: 16 nM
MMP-8, IC50: 1.4 nM
MMP-9, IC50: 12 nM
MMP-13, IC50: 0.75 nM
MMP-14, IC50: 7.4 nM
     
MMP-12, IC50: 0.24 nM
     
MMP3 inhibitor 1
MMP-1, IC50: 14000 nM
MMP-2, IC50: 529 nM
MMP-3, IC50: 1 nM
 
MMP-9, IC50: 2420 nM
 
MMP-14, IC50: 20100 nM
             
HNHA  
MMP-2
   
MMP-9
                 
MMP2-IN-1  
MMP2, IC50: 6.8 μM
                       
Nudol  
MMP-2, Ki: 988.9 nM
   
MMP-9, Ki: 1.76 μM
                 
JG26      
MMP-8, IC50: 240 nM
MMP-9, IC50: >500000 nM
MMP-9, IC50: 1630 nM
 
MMP14, IC50: 19500 nM
ADAM10, IC50: 150 nM
ADAM17, IC50: 1.9 nM
 
MMP-12, IC50: 9.4 nM
   
ADAM8, IC50: 12 nM
MMP-9-IN-4
MMP-1, IC50: 41 nM
MMP-2, IC50: 139 nM
   
MMP-9, IC50: 7.46 nM
MMP-13, IC50: 113 nM
               
MMP-7-IN-1                  
MMP-7, IC50: 10 nM
       
BR351  
MMP-2, IC50: 4 nM
 
MMP-8, IC50: 2 nM
MMP-9, IC50: 11 nM
MMP13, IC50: 50 nM
               
SM-7368        
MMP-9
                  99.90%
β-Neo-Endorphin  
MMP-2
   
MMP-9
                 
TP0556351  
MMP-2, IC50: 0.2 nM
                       
Meloxicam sodium  
MMP-2
                       
MMP-9-IN-3
MMP-1, IC50: 447 nM
MMP-2, IC50: 221 nM
   
MMP-9, IC50: 5.56 nM
MMP13, IC50: 295 nM
               
MMP2-IN-3  
MMP-2, IC50: 31 ± 5 μM
 
MMP-8, IC50: 32 ± 4 μM
MMP-9, IC50: 26.6 ± 2.3 μM
MMP-13, IC50: >100 μM
               
(Rac)-Tanomastat  
MMP-2, Ki: 11 nM
MMP-3, Ki: 143 nM
 
MMP-9, Ki: 301 nM
MMP-13, Ki: 1470 nM
               
MMP-2/9-IN-1  
MMP-2, IC50: 56 nM
   
MMP-9, IC50: 38 nM
                 
FFAGLDD TFA        
MMP9
                 
Imidapril        
MMP-9
                 
MMP2-IN-2  
MMP-2, IC50: 4.2 ± 0.2 μM
 
MMP-8, IC50: 25 ± 10 μM
MMP-9, IC50: 23.3 ± 10. μM
MMP13, IC50: 12 ± 7 μM
               
Dnp-PLGLWA-DArg-NH2 TFA
MMP-1
     
MMP-9
                 
Indinavir sulfate ethanolate  
MMP-2
                       
Anticancer agent 65                        
MMP
 
PI3K/AKT-IN-2  
MMP-2
                       
XL-784 free base
MMP-1, IC50: 1900 nM
MMP-2, IC50: 0.81 nM
MMP-3, IC50: 120 nM
MMP-8, IC50: 10.8 nM
MMP-9, IC50: 18 nM
MMP-13, IC50: 0.56 nM
               
CTTHWGFTLC, CYCLIC  
MMP-2
   
MMP-9
                 
WAY-170523
MMP-1, IC50: 10 μM
     
MMP-9, IC50: 945 nM
MMP13, IC50: 17 nM