MMP Inhibitors

MMP-1

MMP-2

MMP-3

MMP-8

MMP-9

MMP-13

MMP-14

MMP-17

ADAM10

ADAM17

MMP-7

MMP-12

MMP-10

MMP

ADAM8

MMP Inducers, Inhibitors, Agonists, Activators & Chemicals

Product Name	MMP-1	MMP-2	MMP-3	MMP-8	MMP-9	MMP-13	MMP-14	MMP-17	ADAM10	ADAM17	MMP-7	MMP-12	MMP-10	MMP	ADAM8	Purity
Ilomastat	Fibroblast collagenase, Ki: 0.4 nM (Human skin) MMP-1, IC₅₀: 1.5 nM	MMP-2, IC₅₀: 1.1 nM	MMP-3, IC₅₀: 1.9 nM		MMP-9, IC₅₀: 0.5 nM											98.33%
Chloramphenicol						MMP13										99.82%
KP-457		MMP2, IC₅₀: 717 nM	MMP3, IC₅₀: 9760 nM	MMP8, IC₅₀: 2200 nM	MMP9, IC₅₀: 5410 nM	MMP13, IC₅₀: 930 nM	MMP14, IC₅₀: 2140 nM	MMP17, IC₅₀: 7100 nM	ADAM10, IC₅₀: 748 nM	ADAM17, IC₅₀: 11.1 nM						99.18%
Astragaloside IV		MMP-2			MMP-9											≥98.0%
Cordycepin	MMP-1		MMP-3													99.17%
Marimastat	MMP-1, IC₅₀: 5 nM	MMP-2, IC₅₀: 6 nM	MMP-3, IC₅₀: 3 nM				MMP-14, IC₅₀: 9 nM				MMP-7, IC₅₀: 13 nM					≥98.0%
Salvianolic acid A					MMP-9											99.72%
Meloxicam		MMP-2														99.70%
SB-3CT		MMP-2, Ki: 13.9 nM			MMP-9, Ki: 600 nM											99.59%
GW280264X									ADAM10, IC₅₀: 11.5 nM	ADAM17, IC₅₀: 8 nM						98.28%
MMP-9-IN-1					MMP-9											99.71%
Aderbasib									ADAM10	ADAM17						98.09%
TAPI-2														MMP, IC₅₀: 20 μM		99.46%
Tranexamic acid	MMP-1															≥98.0%
Indinavir sulfate		MMP-2														99.96%
Isofraxidin											MMP-7					99.00%
ARP-100	MMP-1, IC₅₀: >50 μM	MMP-2, IC₅₀: 12 nM	MMP-3, IC₅₀: 4.5 μM		MMP-9, IC₅₀: 0.2 μM						MMP-7, IC₅₀: >50 μM					≥99.0%
Prinomastat	MMP-1, IC₅₀: 79 nM	MMP-2, Ki: 0.05 nM	MMP-3, IC₅₀: 6..3 nM MMP-3, Ki: 0.3 nM		MMP-9, IC₅₀: 5 nM MMP-9, Ki: 0.26 nM											≥98.0%
Auraptene		MMP-2														99.86%
Cetrimonium bromide		MMP-2			MMP-9											≥98.0%
FSL-1 TFA					MMP-9											99.76%
Lixisenatide	MMP-1		MMP-3			MMP13										99.93%
UK 356618	MMP-1, IC₅₀: 51 μM	MMP-2, IC₅₀: 1.79 μM	MMP-3, IC₅₀: 5.9 nM		MMP-9, IC₅₀: 0.84 μM	MMP-13, IC₅₀: 73 nM	MMP-14, IC₅₀: 1.9 μM									98.91%
PD-166793	MMP-1, IC₅₀: 6.0 μM	MMP-2, IC₅₀: 4 nM	MMP-3, IC₅₀: 7 nM		MMP-9, IC₅₀: 7.9 μM	MMP-13, IC₅₀: 8 nM					MMP-7, IC₅₀: 7.2 μM					99.45%
Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2	MMP-1, Km: 27.5 μM					MMP-13, Km: 5.2 μM	MMP-14, Km: 7.9 μM									99.87%
Morroniside		MMP2			MMP9											98.55%
PF-00356231 hydrochloride			MMP-3, IC₅₀: 0.39 μM	MMP-8, IC₅₀: 1.7 μM	MMP-9, IC₅₀: 0.98 μM	MMP13, IC₅₀: 0.65 nM						MMP-12, IC₅₀: 1.4 μM				99.52%
Ginkgolide C					MMP-9											≥98.0%
PPNDS tetrasodium									ADAM10, IC₅₀: 1.2 μM
Cynaropicrin						MMP13										99.71%
DB04760						MMP-13, IC₅₀: 8 nM										99.33%
Isoliquiritin apioside					MMP9											99.87%
Anethole					MMP-9											99.78%
β-Neo-Endorphin		MMP-2			MMP-9											98.22%
Hepcidin-1 (mouse) (TFA)					MMP-9											98.94%
MMP-7-IN-1											MMP-7, IC₅₀: 10 nM					99.68%
S 3304					MMP-9											99.11%
SM-7368					MMP-9											99.90%
YH-306		MMP2			MMP9											98.01%
MMP3 inhibitor 1	MMP-1, IC₅₀: 14000 nM	MMP-2, IC₅₀: 529 nM	MMP-3, IC₅₀: 1 nM		MMP-9, IC₅₀: 2420 nM		MMP-14, IC₅₀: 20100 nM									99.03%
Cipemastat	collagenases 1, Ki: 3.0 nM	gelatinase A, Ki: 154 nM	stromelysins 1, Ki: 527 nM	collagenases 2, Ki: 4.4 nM	gelatinase B, Ki: 59.1 nM	collagenases 3, Ki: 3.4 nM										99.81%
JG26				MMP-8, IC₅₀: 240 nM	MMP-9, IC₅₀: >500000 nM MMP-9, IC₅₀: 1630 nM		MMP14, IC₅₀: 19500 nM		ADAM10, IC₅₀: 150 nM	ADAM17, IC₅₀: 1.9 nM		MMP-12, IC₅₀: 9.4 nM			ADAM8, IC₅₀: 12 nM	98.01%
Imidapril hydrochloride					MMP-9											99.80%
UK-370106		MMP-2, IC₅₀: 34.2 μM	MMP-3, IC₅₀: 23 nM	MMP-8, IC₅₀: 1.75 μM	MMP-9, IC₅₀: 30.4 μM	MMP-13, IC₅₀: 2.3 μM	MMP-14, IC₅₀: 66.9 μM				MMP-7, IC₅₀: 5.8 μM	MMP-12, IC₅₀: 42 nM				≥99.0%
PI3K/AKT-IN-2		MMP-2														98.10%
MMP2-IN-1		MMP2, IC₅₀: 6.8 μM														99.18%
NFF-3 TFA			MMP-3										MMP-10			98.57%
MMP-2 Inhibitor I		MMP-2, Ki: 1.7 μM														99.23%
MMP-1-IN-1	MMP-1, IC₅₀: 0.034 μM															99.10%
Otaplimastat														MMP		98.41%
CTTHWGFTLC, CYCLIC TFA		MMP-2			MMP-9											98.60%
Prinomastat hydrochloride	MMP-1, IC₅₀: 79 nM	MMP-2, Ki: 0.05 nM			MMP-9, IC₅₀: 5 nM MMP-9, Ki: 0.26 nM	MMP-13, IC₅₀: 6.3 nM MMP-13, Ki: 0.3 nM										98.18%
Mca-PLAQAV-Dpa-RSSSR-NH2 TFA									ADAM10	ADAM17						99.21%
BI-4394		MMP-2, IC₅₀: 18 μM			MMP-9, IC₅₀: 8.9 μM	MMP-13, IC₅₀: 1 nM	MMP-14, IC₅₀: 8.3 μM						MMP-10, IC₅₀: 16 μM			99.91%
MMP13-IN-2		MMP-2, IC₅₀: 180 nM	MMP-3, IC₅₀: 1100 nM			MMP-13, IC₅₀: 0.036 nM										99.85%
CMC2.24	MMP-1, IC₅₀: 69.8 μM	MMP-2, IC₅₀: 4.8 μM	MMP-3, IC₅₀: 2.9 μM	MMP-8, IC₅₀: 4.5 μM	MMP-9, IC₅₀: 8 μM	MMP-13, IC₅₀: 2.7 μM	MMP-14, IC₅₀: 15.3 μM				MMP-7, IC₅₀: 5 μM	MMP-12, IC₅₀: 2 μM
Tanomastat		MMP-2, Ki: 11 nM	MMP-3, Ki: 143 nM		MMP-9, Ki: 301 nM	MMP-13, Ki: 1470 nM										≥99.0%
cis-ACCP		MMP-2, IC₅₀: 4 μM			MMP-9, IC₅₀: 20 μM
MMPI-1154	MMP-1, IC₅₀: 10 μM	MMP-2, IC₅₀: 6.6 μM			MMP-9, IC₅₀: 13 μM	MMP-13, IC₅₀: 1.8 μM										99.87%
MMP2-IN-3		MMP-2, IC₅₀: 31 ± 5 μM		MMP-8, IC₅₀: 32 ± 4 μM	MMP-9, IC₅₀: 26.6 ± 2.3 μM	MMP-13, IC₅₀: >100 μM										99.64%
Hepcidin-1 (mouse)					MMP-9
MMP-9/10-IN-2													MMP-10, IC₅₀: 0.076 μM
Imidapril					MMP-9											≥99.0%
MMP-9/MMP-13 Inhibitor I	MMP-1, IC₅₀: 43 nM		MMP-3, IC₅₀: 23 nM		MMP-9, IC₅₀: 0.9 nM	MMP-13, IC₅₀: 0.9 nM					MMP-7, IC₅₀: 931 nM					99.90%
MMP2-IN-2		MMP-2, IC₅₀: 4.2 ± 0.2 μM		MMP-8, IC₅₀: 25 ± 10 μM	MMP-9, IC₅₀: 23.3 ± 10. μM	MMP13, IC₅₀: 12 ± 7 μM										98.80%
MMP-7-IN-2		MMP-2, IC₅₀: 33000	MMP-3, IC₅₀: >100000	MMP-8, IC₅₀: >100000	MMP-9, IC₅₀: >100000	MMP-13, IC₅₀: >100000	MMP-14, IC₅₀: 11000 nM				MMP-7, IC₅₀: 16 nM	MMP-12, IC₅₀: 12000 nM				99.34%
ND-336		MMP-2, Ki: 85 nM			MMP-9, Ki: 150 nM		MMP-14, Ki: 120 nM
Indinavir		MMP-2
TP0597850		MMP2, IC₅₀: 0.22 nM				MMP13, IC₅₀: 240 nM						MMP-12, IC₅₀: 250 nM				99.09%
FFAGLDD					MMP9
MMP-2 Inhibitor II	MMP-1, Ki: 45 μM	MMP-2, Ki: 2.4 μM									MMP-7, Ki: 379 μM
(R)-ND-336		MMP-2, Ki: 127 nM			MMP-9, Ki: 19 nM		MMP-14, Ki: 119 nM
Mca-Pro-Leu-Ala-Cys(Mob)-Trp-Ala-Arg-Dap(Dnp)-NH2							MMP-14
Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2	MMP-1		MMP-3
CP-471474	MMP-1, IC₅₀: 1170 nM	MMP-2, IC₅₀: 0.7 nM	MMP-3, IC₅₀: 16 nM		MMP-9, IC₅₀: 13 nM	MMP-13, IC₅₀: 0.9 nM
MMP-8 inhibitor-1				MMP-8
BPHA	MMP-1, IC₅₀: 974 nM	MMP-2, IC₅₀: 12 nM	MMP-3, IC₅₀: >1000 nM		MMP-9, IC₅₀: 16 nM		MMP-14, IC₅₀: 17 nM				MMP-7, IC₅₀: 795 nM
MMP-9-IN-5	MMP-1, IC₅₀: 104 nM	MMP-2, IC₅₀: 266 nM			MMP-9, IC₅₀: 4.49 nM	MMP-13, IC₅₀: 280 nM
RXP470.1												human MMP-12, Ki: 0.2 nM
CP-544439	MMP-1, IC₅₀: 420 nM	MMP-2, IC₅₀: 1.6 nM	MMP-3, IC₅₀: 16 nM	MMP-8, IC₅₀: 1.4 nM	MMP-9, IC₅₀: 12 nM	MMP-13, IC₅₀: 0.75 nM	MMP-14, IC₅₀: 7.4 nM					MMP-12, IC₅₀: 0.24 nM
HNHA		MMP-2			MMP-9
Hydrangenol	MMP-1		MMP-3
MMP12-IN-3												MMP-12, IC₅₀: 4.9 nM
Nudol		MMP-2, Ki: 988.9 nM			MMP-9, Ki: 1.76 μM
MMP-9-IN-4	MMP-1, IC₅₀: 41 nM	MMP-2, IC₅₀: 139 nM			MMP-9, IC₅₀: 7.46 nM	MMP-13, IC₅₀: 113 nM
Anticancer agent 183					MMP-9
BR351		MMP-2, IC₅₀: 4 nM		MMP-8, IC₅₀: 2 nM	MMP-9, IC₅₀: 11 nM	MMP13, IC₅₀: 50 nM
TP0556351		MMP-2, IC₅₀: 0.2 nM
ROCK2-IN-7		MMP-2
MMP-9-IN-7					MMP-9, IC₅₀: 0.52 μM
Funalenone	collagenases 1
proMMP-9 selective inhibitor-1					MMP-9
MMP-9-IN-3	MMP-1, IC₅₀: 447 nM	MMP-2, IC₅₀: 221 nM			MMP-9, IC₅₀: 5.56 nM	MMP13, IC₅₀: 295 nM
(Rac)-Tanomastat		MMP-2, Ki: 11 nM	MMP-3, Ki: 143 nM		MMP-9, Ki: 301 nM	MMP-13, Ki: 1470 nM
MMP-2/9-IN-1		MMP-2, IC₅₀: 56 nM			MMP-9, IC₅₀: 38 nM
FFAGLDD TFA					MMP9
NFF-3			MMP-3										MMP-10
Mca-PLAQAV-Dpa-RSSSR-NH2									ADAM10	ADAM17
AChE-IN-51		MMP-2, IC₅₀: 724 nM
MMP Inhibitor II	MMP-1, IC₅₀: 24 nM		MMP-3, IC₅₀: 18.4 nM		MMP-9, IC₅₀: 2.7 nM						MMP-7, IC₅₀: 30 nM
MMP-13-IN-1						MMP13, IC₅₀: 16 nM
Dnp-PLGLWA-DArg-NH2 TFA	MMP-1				MMP-9
Indinavir sulfate ethanolate		MMP-2
Anticancer agent 65														MMP
CL-82198 hydrochloride						MMP13
XL-784 free base	MMP-1, IC₅₀: 1900 nM	MMP-2, IC₅₀: 0.81 nM	MMP-3, IC₅₀: 120 nM	MMP-8, IC₅₀: 10.8 nM	MMP-9, IC₅₀: 18 nM	MMP-13, IC₅₀: 0.56 nM
CTTHWGFTLC, CYCLIC		MMP-2			MMP-9
WAY-170523	MMP-1, IC₅₀: 10 μM				MMP-9, IC₅₀: 945 nM	MMP13, IC₅₀: 17 nM
MMP-9-IN-9	MMP-1, IC₅₀: 1050 nM				MMP-9, IC₅₀: 5 nM	MMP-13, IC₅₀: 113 nM

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