1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Tetracycline

Tetracycline 

Cat. No.: HY-A0107 Purity: ≥98.0%
Handling Instructions

Tetracycline is a broad-spectrum antibiotic with oral activity. Tetracycline exhibits activity against a wide range of bacteria including gram-positive, gram-negative bacteria, chlamydiae, mycoplasmas and rickettsiae. Tetracycline can be used for the research of infections.

For research use only. We do not sell to patients.

Tetracycline Chemical Structure

Tetracycline Chemical Structure

CAS No. : 60-54-8

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Customer Review

Based on 17 publication(s) in Google Scholar

Other Forms of Tetracycline:

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  • Biological Activity

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Description

Tetracycline is a broad-spectrum antibiotic with oral activity. Tetracycline exhibits activity against a wide range of bacteria including gram-positive, gram-negative bacteria, chlamydiae, mycoplasmas and rickettsiae. Tetracycline can be used for the research of infections[1].

IC50 & Target

Bacterial[1]

In Vitro

Tetracycline shows susceptibilfty of V. vulnlflcus strain B3547 with MIC of 0.5 g/ml[2].
Tetracycline inhibites the L-amyloid aggregates formation and disassembles the pre-formed fibrils. Cerebral deposition of L-amyloid is a major neuro pathological feature in Alzheimer's disease[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tetracycline (3 mg/kg; i.p. every 12 h until survive) can survives mice from bacteremia[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female ICR mice weight 30 to 40 g with V. vulnificus strain B3547 infection[2]
Dosage: 3 mg/kg
Administration: Intraperitoneal injection; 3 mg/kg every 12 h until survive
Result: Inhibited the growth of human CNE-2 xenografts in nude mice.
Clinical Trial
Molecular Weight

444.43

Formula

C22H24N2O8

CAS No.
SMILES

O=C(C(C1=O)=C(O)[[email protected]@H](N(C)C)[[email protected]]2([H])C[[email protected]]3([H])[[email protected]](C)(O)C4=C(C(C3=C(O)[[email protected]@]21O)=O)C(O)=CC=C4)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (281.26 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (ultrasonic) (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2501 mL 11.2504 mL 22.5007 mL
5 mM 0.4500 mL 2.2501 mL 4.5001 mL
10 mM 0.2250 mL 1.1250 mL 2.2501 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.68 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.68 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥98.0%

References
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Product Name:
Tetracycline
Cat. No.:
HY-A0107
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