2. Anti-infection
  3. Bacterial Antibiotic
  4. Tetracycline

Tetracycline 

Cat. No.: HY-A0107 Purity: ≥98.0%
COA Handling Instructions

Tetracycline is a broad-spectrum antibiotic with oral activity. Tetracycline exhibits activity against a wide range of bacteria including gram-positive, gram-negative bacteria, chlamydiae, mycoplasmas and rickettsiae. Tetracycline can be used for the research of infections.

For research use only. We do not sell to patients.

Tetracycline Chemical Structure

Tetracycline Chemical Structure

CAS No. : 60-54-8

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Based on 26 publication(s) in Google Scholar

Other Forms of Tetracycline:

Tetracycline Related Antibodies

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • Biological Activity

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Description

Tetracycline is a broad-spectrum antibiotic with oral activity. Tetracycline exhibits activity against a wide range of bacteria including gram-positive, gram-negative bacteria, chlamydiae, mycoplasmas and rickettsiae. Tetracycline can be used for the research of infections[1].

IC50 & Target

Tetracycline

 

In Vitro

Tetracycline shows susceptibilfty of V. vulnlflcus strain B3547 with MIC value of 0.5 g/mL[2].
Tetracycline inhibits the L-amyloid aggregates formation and disassembles the pre-formed fibrils[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tetracycline Related Antibodies
In Vivo

Tetracycline (3 mg/kg; i.p. every 12 h until survive) survives mice from bacteremia[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female ICR mice weight 30 to 40 g with V.vulnificus strain B3547 infection[2]
Dosage: 3 mg/kg
Administration: Intraperitoneal injection; 3 mg/kg every 12h until survive
Result: Inhibited the growth of human CNE-2 xenografts in nude mice.
Clinical Trial
Molecular Weight

444.43

Appearance

Solid

Formula

C22H24N2O8
CAS No.
SMILES

O=C(C(C1=O)=C(O)[C@@H](N(C)C)[C@]2([H])C[C@]3([H])[C@](C)(O)C4=C(C(C3=C(O)[C@@]21O)=O)C(O)=CC=C4)N
Structure Classification
Initial Source

Shigella dysenteriae
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (281.26 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2501 mL 11.2504 mL 22.5007 mL
5 mM 0.4500 mL 2.2501 mL 4.5001 mL
10 mM 0.2250 mL 1.1250 mL 2.2501 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (4.68 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (4.68 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (255 KB) HNMR (290 KB) MS (180 KB)

Handling Instructions (2659 KB)
References
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Tetracycline Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Tetracycline60-54-8BacterialAntibioticoralbroad-spectrumantibioticbacterialInhibitorinhibitorinhibit

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