1. Metabolic Enzyme/Protease
    Anti-infection
  2. MMP
    Bacterial
  3. Doxycycline (hyclate)

Doxycycline (hyclate) (Synonyms: Doxycycline hydrochloride hemiethanolate hemihydrate; WC2031)

Cat. No.: HY-N0565B Purity: 99.19%
Handling Instructions

Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate), an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor.

For research use only. We do not sell to patients.

Doxycycline (hyclate) Chemical Structure

Doxycycline (hyclate) Chemical Structure

CAS No. : 24390-14-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in Water USD 55 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
1 g USD 60 In-stock
Estimated Time of Arrival: December 31
5 g USD 72 In-stock
Estimated Time of Arrival: December 31
10 g   Get quote  
50 g   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 8 publication(s) in Google Scholar

Other Forms of Doxycycline (hyclate):

Top Publications Citing Use of Products

    Doxycycline (hyclate) purchased from MCE. Usage Cited in: Cancer Lett. 2016 Jun 28;376(1):188-96.

    Doxycycline inducible shRNA can effectivly knockdown the expression of AKT in HCC cells. Cells are treated with 100ng/mL Doxcycline and cultured for the indicated times.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate), an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor[1].

    In Vitro

    Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate) affects growth of glioma cells only under high concentrations[2].
    Doxycycline (hyclate) decreases MT-CO1 protein content with concentrations of 1 µg/mL and higher in SVG cells[2].

    Cell Proliferation Assay[2]

    Cell Line: LNT-229, G55, and U343 glioma cells
    Concentration: 0.01, 0.1, 1, or 10 µg/mL
    Incubation Time: 4 days
    Result: Affected growth of glioma cells only under high concentrations.

    Western Blot Analysis[2]

    Cell Line: SVG cells
    Concentration: 0.01, 0.1, 1, or 10 µg/mL
    Incubation Time: 24 hours
    Result: Decreaseed MT-CO1 protein content with concentrations of 1 µg/mL and higher.
    In Vivo

    Doxycycline (hyclate) (Doxycycline hydrochloride hemiethanolate hemihydrate) (oral; 200 or 800 mg/kg/day; for 3 months) reduces active MMP-9 in untreated HT mice in a dose-dependent manner[1].

    Animal Model: 6-month-old female Heterozygous Col3a1-deficient (HT) mice[1]
    Dosage: 200 or 800 mg/kg
    Administration: Oral; per day; for 3 months
    Result: Reduced active MMP-9 in a dose-dependent manner.
    Clinical Trial
    Molecular Weight

    512.94

    Formula

    C₂₂H₂₄N₂O₈.₁/₂C₂H₆O.ClH.₁/₂H₂O

    CAS No.

    24390-14-5

    SMILES

    O=C(C(C1=O)=C(O)[[email protected]@H](N(C)C)[[email protected]]2([H])[[email protected]@H](O)[[email protected]]3([H])[[email protected]@H](C)C4=C(C(C3=C(O)[[email protected]@]21O)=O)C(O)=CC=C4)N.Cl.[0.5H2O].[0.5C2H6O]

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    H2O : 30 mg/mL (58.49 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.9495 mL 9.7477 mL 19.4955 mL
    5 mM 0.3899 mL 1.9495 mL 3.8991 mL
    10 mM 0.1950 mL 0.9748 mL 1.9495 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Doxycycline is dissolved in 50 mL of drinking water containing 10% sucrose and then mixed with 100 g of mouse chow[5].

    References

    Purity: 99.19%

    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    Doxycycline (hyclate)Doxycycline hydrochloride hemiethanolate hemihydrateWC2031WC 2031WC-2031MMPBacterialMatrix metalloproteinasesInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product name

     

    Salutation

    Applicant name *

     

    Email address *

    Phone number *

     

    Organization name *

    Country or Region *

     

    Requested quantity *

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product name:
    Doxycycline (hyclate)
    Cat. No.:
    HY-N0565B
    Quantity:
    MCE Japan Authorized Agent: