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  4. Gentamicin

Gentamicin, an aminoglycoside antibiotic, inhibits the growth of both gram-positive and gram-negative bacteria and to inhibit several strains of mycoplasma in tissue culture. Gentamicin inhibits DNase I with an IC50 of 0.57 mM.

For research use only. We do not sell to patients.

CAS No. : 1403-66-3

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Customer Review

Based on 64 publication(s) in Google Scholar

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Gentamicin Related Antibodies

Top Publications Citing Use of Products

64 Publications Citing Use of MCE Gentamicin

Microbiological Assay

    Gentamicin purchased from MedChemExpress. Usage Cited in: Microorganisms. 2024 Mar 13;12(3):575.

    Percentages of E. coli strains showing antimicrobial resistance to different antimicrobial agents. AMP, Ampicillin; CAZ, Ceftazidime; IPM, Imipenem; MRP, Meropenem; GEN, Gentamicin; OFX, Ofloxacin; SXT, Trimethoprim–sulfamethoxazole; TET, Tetracycline; TGC, Tigecycline; CL, Colistin; FFC, Florfenicol.

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    Description

    Gentamicin, an aminoglycoside antibiotic, inhibits the growth of both gram-positive and gram-negative bacteria and to inhibit several strains of mycoplasma in tissue culture. Gentamicin inhibits DNase I with an IC50 of 0.57 mM[1][2][3][4].

    IC50 & Target

    Aminoglycoside

     

    In Vitro

    Gentamicin is a more effective in vitro bacterial inhibitor than combined penicillin-streptomycin, is nontoxic to tissue culture monolayers, and does not inhibit virus replication[2].
    Gentamicin has been used with success as an additive in commercial mycology media to inhibit growth of bacteria and has been shown to be bactericidal for a wider range of organisms (Pseudomonas aeruginosa, Proteus sp., and Streptococcus faecalis) than penicillin and streptomycin[2].
    Gentamicin does not interfere with the production of cytopathic effect by certain echoviruses and polioviruses in tissue culture, is nontoxic to Rhesus monkey kidney, HeLa, and human amnion cells, and is stable at autoclave temperatures[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Gentamicin Related Antibodies
    In Vivo

    Gentamicin (10 mg/kg; s.c.; every 12 h for a total of six doses) improves survival and alters the inflammatory profile in a murine model of depsis from P. aeruginosa[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: FVB/N mice (6-10-week-old; ~20 g) received an intratracheal injection of a solution containing the ATCC 27853 strain of P. aeruginosa[3].
    Dosage: 10 mg/kg
    Administration: Subcutaneous injection (s.c.); every 12 h for a total of six doses
    Result: Survival at 7 days was 100% for mice. Down-regulated the proinflammatory cytokines, IL-6.
    Formula

    C24H53N7O73*
    CAS No.
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    O[C@]1(C)C(NC)[C@@H](O)[C@@H](O[C@H]2C(N)C[C@H](N)[C@@H](O[C@@H]3[C@H](N)CC[C@@H]([R])O3)[C@@H]2O)OC1.NC[*].C[C@H]([*])N.C[C@H]([*])NC.[R=].[or].[or]
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, protect from light, stored under nitrogen

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

    Solvent & Solubility
    In Vitro: 

    H2O : 175 mg/mL (Need ultrasonic)

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    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    SDS (419 KB)

    COA (247 KB) HNMR (230 KB)

    Handling Instructions (2659 KB)
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    Gentamicin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Gentamicin1403-66-3Environmental PollutantsBacterialAntibioticEnvironmental ContaminantsMeniere’s diseaseglandular tularemiaInhibitorinhibitorinhibit

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