1. Immunology/Inflammation
  2. Interleukin Related
  3. Dupilumab

Dupilumab  (Synonyms: REGN-668; SAR-231893)

Cat. No.: HY-P9926 Purity: ≥99.2%

Dupilumab (REGN-668) is a fully human mAb to IL-4 receptor α (IL-4Rα) that inhibits both IL-4 and IL-13 signaling, markedly improved moderate-to-severe atopic dermatitis.

For research use only. We do not sell to patients.

Dupilumab Chemical Structure

Dupilumab Chemical Structure

CAS No. : 1190264-60-8

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1 mg USD 290 In-stock
Estimated Time of Arrival: December 31
5 mg USD 880 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1400 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Dupilumab

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review


Dupilumab (REGN-668) is a fully human mAb to IL-4 receptor α (IL-4Rα) that inhibits both IL-4 and IL-13 signaling, markedly improved moderate-to-severe atopic dermatitis[1].

IC50 & Target[1]







In Vitro

Dupilumab suppressed mRNA expressions of genes related to activation of T cells, DCs, eosinophils, inflammatory pathways, and TH2-inducing chemokines in skin lesions. No significant reduction in IL-17A or IL-22 levels is detected, but large reductions in expression of IL-17–related genes, such as elafin (PI3), IL23p19/IL23A, and S100A8 and trends for suppression (CXCL1 and S100A7) are found with 300 mg of Dupilumab[1].
Major suppressions of hyperplasia-related genes (eg, K16) and reductions in expression of S100A genes are evident with 300 mg of Dupilumab by using microarrays and qRT-PCR. The changes in other critical epidermal alterations in severe atopic dermatitis (AD) skin are also measured, including significant increases in claudin and lipid product levels with 300 mg of Dupilumab. A trend of dose-dependent increases in expression of differentiation genes (LOR and FLG) is observed after adjusting for suppression of epidermal hyperplasia, as demonstrated by K16 reductions with Dupilumab[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial





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Purity & Documentation

Purity: ≥99.2%

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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