Human IgG4 (S228P) kappa, Isotype Control
Based on 11 publication(s) in Google Scholar
Human IgG4 (S228P) kappa, Isotype Control, a human-derived monoclonal antibody, is an isotype control for human IgG4κ antibody.
For research use only. We do not sell to patients.
- Purity: 99.35%
- Molecular Weight:142.35 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications Citing Use of MedChemExpress (MCE) Human IgG4 (S228P) kappa, Isotype Control
More- Nat Cancer. 2025 Apr 16. [Abstract]
- Nat Commun. 2024 Aug 7;15(1):6726. [Abstract]
- Gut Microbes. 2023 Dec;15(2):2249143. [Abstract]
- Cell Death Dis. 2025 Dec 19. [Abstract]
- NPJ Breast Cancer. 2026 Apr 3;12(1):52. [Abstract]
- bioRxiv. 2026 Apr 30.
- bioRxiv. 2026 Mar 10.
- bioRxiv. 2025 Nov 24.
- University Medicine Berlin. 2025.
- bioRxiv. 2025 Jan 25:2025.01.24.631210. [Abstract]
- SSRN. 2024 Oct 28.
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In Vivo Efficacy Study
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Cell Proliferation/Viability Assay
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Cell Imaging/Staining
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RT-PCR
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2D/3D Cell Culture and Differentiation
Biological Activity
Human IgG4 (S228P) kappa, Isotype Control is often used as the experimental negative control. Human IgG4 (S228P) kappa, Isotype Control exhibits similar structure and biological properties as human immunoglobulin G4 (IgG4), but lacks specific antigen binding ability[2].
Human IgG4 (S228P) kappa, Isotype Control (80 μg/mL, 1 h) exhibits no resistant effects against KRCV-1 and PBJV infection in MA-104 cell (Orilanolimab (HY-P99791) is used as the control in the experiment)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
ELISA, FACS, Functional assay
Chemical Information
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Appearance Liquid
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Molecular Weight 142.35 kDa
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Color Colorless to light yellow
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SMILES
[Human IgG4 (S228P) kappa, Isotype Control]
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (11)
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Journal Impact Factor
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Most Recent
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Nat Cancer
Dual modulation of cytotoxic and checkpoint receptors tunes the efficacy of adoptive Delta One T cell therapy against colorectal cancer. [Abstract]2025 Apr 16. PMID: 40240620 -
Nat Commun
2024 Aug 7;15(1):6726. PMID: 39112502
Human IgG4 (S228P) kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Aug 7;15(1):6726. [Abstract]
An isotype control antibody (IgG4, κ, solid circles, 0–80 µg/ml, 25 h) was used as a negative control to demonstrate that the dose-dependent blockade of SHFV infection in MA-104 cells was specifically mediated by orilanolimab (open circles).
Human IgG4 (S228P) kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Aug 7;15(1):6726. [Abstract]
Human IgG4 (S228P) kappa isotype control (80 µg/ml, 24h) was used as a negative control to demonstrate that the blockade of SHFV infection was specifically mediated by orilanolimab across multiple cell types, including uninfected cells, wild-type MA-104 cells, ACHN+hCD163 cells, and macaque iPSC-derived macrophages.
Human IgG4 (S228P) kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Aug 7;15(1):6726. [Abstract]
Human IgG4 (S228P) kappa isotype control (80 µg/ml, 24 h) was used as a negative control to demonstrate that orilanolimab reduced the replication of SHFV, KRCV-1, and PBJV.
Human IgG4 (S228P) kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Aug 7;15(1):6726. [Abstract]
Human IgG4 (S228P) kappa isotype control (80 µg/ml, 24 h) was used as a negative control to demonstrate that orilanolimab enhanced the overall survivability of macaque iPSC-derived macrophages in the presence of arteriviruses.
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Gut Microbes
Microbial metabolite butyrate promotes anti-PD-1 antitumor efficacy by modulating T cell receptor signaling of cytotoxic CD8 T cell. [Abstract]2023 Dec;15(2):2249143. PMID: 37635362 -
Cell Death Dis
Dexamethasone drives macrophage repolarization linked to increased triple-negative breast cancer aggressiveness. [Abstract]2025 Dec 19. PMID: 41413093 -
NPJ Breast Cancer
TGF-α/EGFR-mediated lymphatic metastasis reveals a repositionable therapeutic target in breast cancer. [Abstract]2026 Apr 3;12(1):52. PMID: 41932901 -
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Human IgG4 (S228P) kappa, Isotype Control purchased from MedChemExpress. Usage Cited in: bioRxiv. 2025 Nov 24.
Isotype control antibodies (IgG4κ and IgG1κ) were used as negative controls to demonstrate that pembrolizumab (anti-PD-1) and fragifilimab (anti-GITR) showed no inhibition of tumor growth in the HU-CD34+ T188 PDOX mouse model.
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bioRxiv
Genome-scale spatial mapping of the Hodgkin lymphoma microenvironment identifies tumor cell survival factors. [Abstract]2025 Jan 25:2025.01.24.631210. PMID: 39896575 -
Purity & Documentation
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Data Sheet (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)