1. Immunology/Inflammation
  2. PD-1/PD-L1
  3. Nivolumab

Nivolumab (Synonyms: BMS-936558; ONO-4538; MDX-1106)

Cat. No.: HY-P9903 Purity: 98.56%
Handling Instructions

Nivolumab is a programmed death receptor-1 (PD-1) blocking antibody to treat advanced (metastatic) non-small cell lung cancer.

For research use only. We do not sell to patients.

Nivolumab Chemical Structure

Nivolumab Chemical Structure

CAS No. : 946414-94-4

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1 mg USD 280 In-stock
Estimated Time of Arrival: December 31
5 mg USD 670 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Nivolumab is a programmed death receptor-1 (PD-1) blocking antibody to treat advanced (metastatic) non-small cell lung cancer.

In Vitro

Nivolumab binds to CHO cells expressing PD-1 with an EC50 of 1.66 nM, but does not bind to the parental CHO cell line. Nivolumab binds to PD-1 on activated T cells with an EC50 of 0.64 nM. Nivolumab also inhibits the interaction between PD-1 and its ligands, PD-L1 and PD-L2, with IC50 values of 2.52 and 2.59 nM, respectively. Nivolumab (1.5 ng/mL) can enhance T-cell reactivity in the presence of a T-cell receptor stimulus[1].

In Vivo

Nivolumab (10 and 50 mg/kg, i.v.) is well tolerated in cynomolgus monkeys. Serum chemistry changes are limited to a reversible 28% decrease in T3 at week 13 in females treated with 50 mg/kg. T4 and TSH levels are unchanged. In males treated with 50 mg/kg, there are no changes in T3, T4, or TSH levels. Nivolumab exposure increases in an approximately dose-proportional manner between 10 and 50 mg/kg, with no substantial sex differences noted[1].

Clinical Trial
Molecular Weight







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Purity: 98.56%

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NivolumabBMS-936558ONO-4538MDX-1106BMS936558BMS 936558ONO4538ONO 4538MDX1106MDX 1106PD-1/PD-L1PD-1/Programmed death-ligand 1Inhibitorinhibitorinhibit

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