1. Immunology/Inflammation
    Apoptosis
    Autophagy
  2. PD-1/PD-L1
    Apoptosis
    Autophagy
  3. Atezolizumab

Atezolizumab  (Synonyms: MPDL3280A)

Cat. No.: HY-P9904 Purity: ≥98.0%
COA

Atezolizumab (MPDL3280A) is a selective humanized monoclonal IgG1 antibody against programmed death ligand 1 (PD-L1), used for cancer research.

For research use only. We do not sell to patients.

Atezolizumab Chemical Structure

Atezolizumab Chemical Structure

CAS No. : 1380723-44-3

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1 mg USD 280 In-stock
Estimated Time of Arrival: December 31
5 mg USD 670 In-stock
Estimated Time of Arrival: December 31
25 mg USD 2550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 4080 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 12 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Atezolizumab purchased from MCE. Usage Cited in: EJNMMI Res. 2020 Jun 15;10(1):64.  [Abstract]

    Western blot analysis of total cell lysates using anti-PD-L1 (Atezolizumab, 6.91 nM) and anti-β-actin antibody between LoVo, LS174T, SW620, and RKO in vitro.
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    Description

    Atezolizumab (MPDL3280A) is a selective humanized monoclonal IgG1 antibody against programmed death ligand 1 (PD-L1), used for cancer research.

    In Vitro

    Atezolizumab (0, 2.5, 5, 10, 20, and 40 µg/ml; 24 hours; HOS and 143B cells) inhibits proliferation and induces immune-independent apoptosis of osteosarcoma cells[1].
    Atezolizumab impairs the function of mitochondria to cause the imbalance between oxidants and antioxidants. Atezolizumab induces mitochondria-related apoptosis of osteosarcoma cells by activating JNK pathway. Atezolizumab (10 µg/ml; 24 hours; HOS and 143B cells) induces autophagy in osteosarcoma cells[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    144590.50

    CAS No.
    SMILES

    [Atezolizumab]

    Shipping

    Shipping with dry ice.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    Purity & Documentation

    Purity: 98.98%

    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    Product Name:
    Atezolizumab
    Cat. No.:
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