1. Immunology/Inflammation
    Apoptosis
    Autophagy
  2. PD-1/PD-L1
    Apoptosis
    Autophagy
  3. Atezolizumab

Atezolizumab (Synonyms: MPDL3280A)

Cat. No.: HY-P9904 Purity: 98.98%

Atezolizumab (MPDL3280A) is a selective humanized monoclonal IgG1 antibody against programmed death ligand 1 (PD-L1), used for cancer research.

For research use only. We do not sell to patients.

Atezolizumab Chemical Structure

Atezolizumab Chemical Structure

CAS No. : 1380723-44-3

Size Price Stock Quantity
1 mg USD 280 In-stock
Estimated Time of Arrival: December 31
5 mg USD 670 In-stock
Estimated Time of Arrival: December 31
25 mg USD 2550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 4080 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 8 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Atezolizumab purchased from MCE. Usage Cited in: EJNMMI Res. 2020 Jun 15;10(1):64.

    Western blot analysis of total cell lysates using anti-PD-L1 (Atezolizumab, 6.91 nM) and anti-β-actin antibody between LoVo, LS174T, SW620, and RKO in vitro.
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    Description

    Atezolizumab (MPDL3280A) is a selective humanized monoclonal IgG1 antibody against programmed death ligand 1 (PD-L1), used for cancer research.

    In Vitro

    Atezolizumab (0, 2.5, 5, 10, 20, and 40 µg/ml; 24 hours; HOS and 143B cells) inhibits proliferation and induces immune-independent apoptosis of osteosarcoma cells[1].
    Atezolizumab impairs the function of mitochondria to cause the imbalance between oxidants and antioxidants. Atezolizumab induces mitochondria-related apoptosis of osteosarcoma cells by activating JNK pathway. Atezolizumab (10 µg/ml; 24 hours; HOS and 143B cells) induces autophagy in osteosarcoma cells[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Clinical Trial
    Molecular Weight

    144590.50

    CAS No.
    Shipping

    Shipping with dry ice.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    References

    Purity: 98.98%

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    Product Name:
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    Cat. No.:
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