CXCR4
C-X-C chemokine receptor type 4 (CXCR4, fusin, CD184) is a homeostatic Gαi-coupled receptor with a single ligand, CXCL12 (SDF-1), a pairing conserved from fish to mammals and essential for life: knockout of either gene is perinatally lethal with defects in hematopoiesis, cardiogenesis, vascular and nervous system development. CXCR4 is expressed on hematopoietic stem cells, naive and memory T cells, B cells, monocytes, neutrophils, endothelial and neural progenitors. Its functions span stem-cell retention in the CXCL12-rich bone marrow niche (the therapeutic target of plerixafor for stem-cell mobilization), lymphocyte trafficking and tissue development. CXCR4 is famously the principal co-receptor for X4-tropic HIV-1 strains. In cancer, CXCR4 is the most frequently upregulated chemokine receptor across tumor types, driving organ-specific metastasis toward CXCL12-rich organs (lung, liver, bone marrow, brain), promoting tumor growth, angiogenesis and survival under therapy, and informing metastasis risk stratification; CXCR4 inhibitors are in clinical trials for warts, hypogammaglobulinemia and advanced cancers.
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CXCR4 Recombinant Proteins (6)
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Inhibitors & Agonists (86)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
