1. Signaling Pathways
  2. GPCR/G Protein
    Immunology/Inflammation
  3. CXCR
  4. CXCR4 Inhibitors

CXCR4 Inhibitors

CXCR

CXCR1

CXCR2

CXCR3

CXCR4

CXCR7

CXCR6

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Sorry. There is currently no product that acts on isoform CXCR4 together.

Please try each isoform separately.

CXCR4 Specific Inhibitors, Agonists, Antagonists & Modulators
Product Name CXCR4 CXCR7 CXCR4 Selectivity Purity
Plerixafor
125I-CXCL12-CXCR4, IC50: 44 nM
  Selective Antagonist ≥98.0%
Plerixafor octahydrochloride
125I-CXCL12-CXCR4, IC50: 44 nM
  Selective Antagonist ≥98.0%
Motixafortide
CXCR4, IC50: ~1 nM
  Selective Antagonist 98.27%
Mavorixafor trihydrochloride
125I-SDF-CXCR4, IC50: 13 nM
  Selective Antagonist ≥98.0%
IT1t dihydrochloride
CXCL12/CXCR4, IC50: 2.1 nM
  Selective Antagonist 99.97%
NUCC-390 dihydrochloride
CXCR4
  Selective Agonist 99.59%
Burixafor hydrobromide
CXCR4
  Selective Antagonist ≥98.0%
LY2510924
125I-SDF-1α-CXCR4, IC50: 79.7 pM
125I-SDF-1α-CXCR4, Ki: 49.5 pM
  Selective Inhibitor ≥98.0%
AMD 3465 hexahydrobromide
12G5 mAb-CXCR4, IC50: 0.75 nM (in SupT1 cells)
CXCL12AF647-CXCR4, IC50: 18 nM (in SupT1 cells)
  Selective Antagonist ≥98.0%
WZ811
CXCR4, EC50: 0.3 nM
  Selective Antagonist ≥99.0%
Balixafortide TFA
CXCR4, IC50: <10 nM
  Selective Antagonist 98.19%
MSX-122
CXCR4/CXCL12, IC50: ~10 nM
  Selective Antagonist 98.29%
USL311
CXCR4
  Selective Antagonist 99.97%
FC131 TFA
125I-SDF-1-CXCR4, IC50: 4.5 nM
  Selective Antagonist 99.87%
ALX 40-4C Trifluoroacetate
SDF-1-CXCR4, Ki: 1 μM
  Selective Inhibitor 95.90%
IT1t
CXCL12/CXCR4, IC50: 2.1 nM
  Selective Antagonist
ALX 40-4C
SDF-1-CXCR4, Ki: 1 μM
  Selective Inhibitor
NUCC-390
CXCR4
  Selective Agonist
Mavorixafor
125I-SDF-CXCR4, IC50: 13 nM
  Selective Antagonist
KRH-3955 hydrochloride
SDF-1α-CXCR4, IC50: 0.61 nM
  Selective Antagonist
AMD 3465
12G5 mAb-CXCR4, IC50: 0.75 nM (in SupT1 cells)
CXCL12AF647-CXCR4, IC50: 18 nM (in SupT1 cells)
  Selective Antagonist
Balixafortide
CXCR4, IC50: <10 nM
  Selective Antagonist
MSX-127
CXCR4
  Selective Antagonist
TC14012
CXCR4, IC50: 19.3 nM (antagonist site)
CXCR7, EC50: 350 nM (agonist site)
Selective Modulator
CTCE-9908
CXCR4
  Selective Antagonist
CTCE-9908 TFA
CXCR4
  Selective Antagonist
TC14012 TFA
CXCR4, IC50: 19.3 nM (antagonist site)
CXCR7, EC50: 350 nM (agonist site)
Selective Modulator
ATI-2341
CXCR4, EC50: 194 nM (in CCRF-CEM cells)
  Selective Agonist
CXCR4 antagonist 1
CXCR4
  Selective Antagonist
MSX-130
CXCR4
  Selective Antagonist
FC131
125I-SDF-CXCR4, IC50: 4.5 nM
  Selective Antagonist
Baohuoside I
CXCR4
  Pan Inhibitor 99.70%