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Plerixafor octahydrochloride

(Synonyms: AMD3100 octahydrochloride; JM3100 octahydrochloride; SID791 octahydrochloride)
111 Cited Publications
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Based on 111 publication(s) in Google Scholar

Plerixafor octahydrochloride (AMD3100 octahydrochloride) is a selective CXCR4 antagonist with an IC50 of 44 nM.

For research use only. We do not sell to patients.

  • Purity: 98.03%
  • CAS No.: 155148-31-5
  • Formula: C28H54N8.8HCl
  • Molecular Weight:794.47
  • Storage:

    4°C, sealed storage, away from moisture

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • Plerixafor octahydrochloride Chemical Structure
    Plerixafor octahydrochloride Chemical Structure
  • Experimental Validation Results for Plerixafor octahydrochloride
  • Experimental Validation Results for Plerixafor octahydrochloride
  • Experimental Validation Results for Plerixafor octahydrochloride
  • Experimental Validation Results for Plerixafor octahydrochloride
  • Experimental Validation Results for Plerixafor octahydrochloride
  • Experimental Validation Results for Plerixafor octahydrochloride
  • Experimental Validation Results for Plerixafor octahydrochloride
  • Experimental Validation Results for Plerixafor octahydrochloride
  • Experimental Validation Results for Plerixafor octahydrochloride
  • Experimental Validation Results for Plerixafor octahydrochloride
  • Experimental Validation Results for Plerixafor octahydrochloride
  • Experimental Validation Results for Plerixafor octahydrochloride
  • Experimental Validation Results for Plerixafor octahydrochloride
CAS No.: 155148-31-5
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  • Plerixafor octahydrochloride Chemical Structure
    Plerixafor octahydrochloride Chemical Structure
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    Plerixafor octahydrochloride purchased from MedChemExpress. Usage Cited in: Leukemia. 2025 Aug 15. [Abstract]

    Customer Validation
     Effect of cytokine signaling blockade on ALL cell survival in co-culture with stromal populations. ALL cells were co-cultured with early mesenchymal progenitors, adipogenic progenitors, or cultured alone. Cell survival was assessed after treatment with blocking antibodies against IL7, Osteopontin, or the CXCR4 inhibitor Plerixafor (1 nM; 7 days), Mouse IgG1 kappa, Isotype Control (1 ug/mL; 7 days).

  • 1/16

    Plerixafor octahydrochloride purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2022 Feb 4;13(2):118. [Abstract]

    Customer Validation
     PGK1 induced the CXCR4-mediated phosphorylation of AKT (p-AKT) and ERK (p-ERK), and blockade of CXCR4 signaling by AMD3100 (48 h) treatment did not alter cellular PGK1 expression in KIRC cells.

  • 1/16

    Plerixafor octahydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2022 Oct 7;551:215944. [Abstract]

    Customer Validation
     Viability of cells treated with combinations different concentrations of AMD3100 and Olaparib for 24 h.

  • 1/16

    Plerixafor octahydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2022 Oct 7;551:215944. [Abstract]

    Customer Validation
     Immunohistochemical staining of proliferation-related protein, Ki-67, in breast cancer after treatment with control, AMD3100 (2.5 mg/kg), Olaparib, or a combination of AMD3100 and Olaparib.

  • 1/16

    Plerixafor octahydrochloride purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2021 Jan 7;6(7):2039-2057. [Abstract]

    Customer Validation
     Western blot analysis of the expression of CXCR4, integrin αvβ3, p-Jak2, Jak2, p-FAK, FAK, p-STAT3 and STAT3 in MSCs (pretreated with a CXCR4 inhibitor (AMD3100; 20 μM; pretreated with 1 h) and an integrin αvβ3 inhibitor (cyclo(-RGDfK))) after the addition of 152RM for 24 h.

  • 1/16

    Plerixafor octahydrochloride purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Jan 1;11(6):2612-2633. [Abstract]

    Customer Validation
     Caco-2 cells are incubated with vehicle or AMD3100 (1 µg/ml, 24 hours) after lentivirus transfection (LV-HOXB5), then Western blotting assays are conducted to measure the protein levels of CXCL12, HOXB5, CXCR4, p-ERK and p-ETS1 in the indicated cell lines.

  • 1/16

    Plerixafor octahydrochloride purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Jan 1;11(6):2612-2633. [Abstract]

    Customer Validation
     Transwell assays indicated that AMD3100 treatment (1 µg/ml, 24 hours) significantly decreases the migration and invasion of Caco-2-HOXB5 cells.

  • 1/16

    Plerixafor octahydrochloride purchased from MedChemExpress. Usage Cited in: Cell Mol Immunol. 2020 Mar;17(3):283-299. [Abstract]

    Customer Validation
     ELISA of IL-1β in supernatants of BV2 cells stimulated with gp120 LAV (0.5 μg/mL) for 24 h in the presence of increasing doses of a CXCR4-specific inhibitor (AMD3100, 0.1-10 μM; prestimulated with 30 min-2 h).

  • 1/16

    Plerixafor octahydrochloride purchased from MedChemExpress. Usage Cited in: Adv Funct Mater. 2020, 2000309.

    Customer Validation
     NOD/SCID mice were i.p. injected with AMD3100 (4 mg/kg). After 1 h, the mice are i.v. injected with iFluor 647-labeled Aazo@CMSN. At 12 h after nanoparticle injection, the mouse craniums are excised for the observation of nanoparticle bone marrow niches targeting under CLSM. Pre-treatment with AMD3100 significantly declined the bone marrow niches targeting of the nanoparticles.

  • 1/16

    Plerixafor octahydrochloride purchased from MedChemExpress. Usage Cited in: Oncogene. 2019 Jun;38(25):5021-5037. [Abstract]

    Customer Validation
     IF staining of the tumor tissue sections showed decreased Ki67 and a reversal of EMT markers indicated by increased E-cadherin and decreased N-cadherin expression in the AMD3100 (5 mg/kg or 3.5 mg/kg) treated groups.

  • 1/16

    Plerixafor octahydrochloride purchased from MedChemExpress. Usage Cited in: Oncogene. 2019 Jun;38(25):5021-5037. [Abstract]

    Customer Validation
     Additional EMT-related proteins (Snail and Slug) are downregulated by AMD3100 (5 mg/kg or 3.5 mg/kg) in tumor samples from both diet groups, as quantified by immunoblotting.

  • 1/16

    Plerixafor octahydrochloride purchased from MedChemExpress. Usage Cited in: Cell Physiol Biochem. 2018;46(3):890-906. [Abstract]

    Customer Validation
     The protein expression of LRRC4, SDF-1, CXCR4, ERK, Slit2 and VEGF in the brain tissue of rats is determined by Western blotting.

  • 1/16

    Plerixafor octahydrochloride purchased from MedChemExpress. Usage Cited in: Int J Biol Sci. 2017 May 5;13(5):604-614. [Abstract]

    Customer Validation
     Epithelial cells with or without AMD3100 pretreatment are cultured in conditioned medium (CM) from LPS-treated NFs or LTA-treated NFs for 3 days, and the secretion of TNF-α in the supernatant of culture is detected by ELISA. Epithelial cells cultured in MSM are used as control. Both LPS-treated NFs and LTA-treated NFs enhanced the section of TNF-α by epithelial cells compared with control. Pretreatment of epithelial cells with AMD3100 significantly attenuates the increase of TNF-α.

  • Plerixafor octahydrochloride