1. Signaling Pathways
  2. GPCR/G Protein
    Immunology/Inflammation
  3. CXCR
  4. CXCR Inhibitors

CXCR Inhibitors

CXCR

CXCR1

CXCR2

CXCR3

CXCR4

CXCR7

CXCR6

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Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

CXCR Inhibitors, Agonists, Antagonists, Activators & Modulators
Product Name CXCR CXCR1 CXCR2 CXCR3 CXCR4 CXCR7 CXCR6 Purity
Plerixafor        
125I-CXCL12-CXCR4, IC50: 44 nM
    98.61%
SB225002    
125I-IL-8-CXCR2, IC50: 22 nM (in CHO cell membrane)
        99.87%
AMG 487      
125I-IP10-CXCR3, IC50: 8 nM
125I-ITAC-CXCR3, IC50: 8.2 nM
      99.65%
Reparixin  
CXCR1wt, IC50: 5.6 nM (in L1.2 cells)
CXCR1Ile43Val, IC50: 80 nM (in L1.2 cells)
CXCR1, IC50: 1 nM (in cells)
CXCR2, IC50: ∼100 nM (in cells)
        99.95%
LIT-927        
CXCL12/CXCR4, Ki: 267 nM
    99.86%
Plerixafor octahydrochloride        
125I-CXCL12-CXCR4, IC50: 44 nM
    ≥98.0%
Navarixin  
Cynomolgus CXCR1, Kd: 41 nM
125I-CXCL8-CXCR1, IC50: 43 nM
Mouse CXCR2, Kd: 0.2 nM
Rat CXCR2, Kd: 0.2 nM
Cynomolgus CXCR2, Kd: 0.08 nM
125I-CXCL8-CXCR2, IC50: 0.97 nM
        98.90%
AZD8797    
125I-IL-8-CXCR2, Ki: 2800 nM (in HEK293S cells)
        98.73%
AZD-5069    
125I-IL-8-CXCR2
        99.76%
Motixafortide        
CXCR4, IC50: ~1 nM
    99.88%
TAK-779      
mCXCR3, IC50: 369 nM (in PBMCs)
      99.73%
Mavorixafor trihydrochloride        
125I-SDF-CXCR4, IC50: 13 nM
    98.69%
SCH 546738      
Human CXCR3, Ki: 0.4 nM
      98.71%
SX-682  
CXCR1
CXCR2
        99.67%
Baohuoside I        
CXCR4
    99.96%
ACT-1004-1239          
CXCR7
  99.80%
ML339            
CXCR6, IC50: 140 nM
99.88%
NUCC-390 dihydrochloride        
CXCR4
    99.05%
SB-265610    
CXCR2
        ≥99.0%
NBI-74330      
[125I]CXCL10-CXCR3, Ki: 1.5 nM (in CXCR3-CHO cell membranes)
[125I]CXCL11-CXCR3, Ki: 3.2 nM (in CXCR3-CHO cell membranes)
      98.57%
VUF11207 fumarate          
CXCR7, pKi: 8.1
  98.92%
CXCR7 antagonist-1          
CXCR7
  99.97%
IT1t dihydrochloride        
CXCL12/CXCR4, IC50: 2.1 nM
    99.89%
Reparixin L-lysine salt  
CXCR1wt, IC50: 5.6 nM (in L1.2 cells)
CXCR1Ile43Val, IC50: 80 nM (in L1.2 cells)
CXCR1, IC50: 1 nM (in cells)
CXCR2, IC50: ∼100 nM (in cells)
        99.66%
Danirixin    
CXCL8-CXCR2, IC50: 12.5 nM
        98.45%
WZ811        
CXCR4, EC50: 0.3 nM
    ≥98.0%
PS372424 hydrochloride      
Human CXCR3
      ≥98.0%
LY2510924        
125I-SDF-1α-CXCR4, IC50: 79.7 pM
125I-SDF-1α-CXCR4, Ki: 49.5 pM
    99.73%
Balixafortide TFA        
CXCR4, IC50: <10 nM
    99.78%
TC14012        
CXCR4, IC50: 19.3 nM (antagonist site)
CXCR7, EC50: 350 nM (agonist site)
  99.90%
Nicotinamide N-oxide    
CXCR2
        99.85%
Burixafor hydrobromide        
CXCR4
    ≥98.0%
FC131 TFA        
125I-SDF-1-CXCR4, IC50: 4.5 nM
    99.89%
AMD 3465 hexahydrobromide        
12G5 mAb-CXCR4, IC50: 0.75 nM (in SupT1 cells)
CXCL12AF647-CXCR4, IC50: 18 nM (in SupT1 cells)
    ≥98.0%
MSX-122        
CXCR4/CXCL12, IC50: ~10 nM
    98.92%
Elubrixin tosylate    
CXCR2
        99.78%
CXCR2-IN-1    
CXCR2, pIC50: 9.3
        99.47%
CXCR7 antagonist-1 hydrochloride          
CXCR7
  99.66%
CXCR7 modulator 2          
CXCR7, Ki: 13 nM
  98.39%
Ladarixin sodium  
CXCR1
CXCR2
        99.15%
CXCR2 antagonist 8    
CXCR2
        99.24%
UNBS5162
CXCL
            98.10%
CXCR2-IN-2  
CXCR1, IC50: 3.8 μM
CXCR2, IC50: 5.2 nM
        99.52%
Ulocuplumab        
CXCR4
    99.90%
USL311        
CXCR4
    99.97%
ALX 40-4C Trifluoroacetate        
SDF-1-CXCR4, Ki: 1 μM
   
ACT-777991      
CXCR3
      99.49%
SRT3190    
CXCR2
        99.77%
CTCE-9908        
CXCR4
    99.69%
CXCR7 modulator 1          
CXCR7, Ki: 9 nM
  99.50%
SX-517  
CXCR1
CXCR2
        99.88%
MSX-127        
CXCR4
    99.68%
MSX-130        
CXCR4
    98.00%
AMD 3465        
12G5 mAb-CXCR4, IC50: 0.75 nM (in SupT1 cells)
CXCL12AF647-CXCR4, IC50: 18 nM (in SupT1 cells)
    99.59%
AZD8309    
CXCR2, IC50: 4 nM
        99.98%
ACT-660602      
CXCR3, IC50: 204 nM
      99.86%
IT1t        
CXCL12/CXCR4, IC50: 2.1 nM
   
SCH 563705  
CXCR1, Ki: 3 nM
CXCR1, IC50: 7.3 nM
CXCR2, Ki: 1 nM
CXCR2, IC50: 1.3 nM
Mouse CXCR2, IC50: 5.2 nM
        99.29%
ALX 40-4C        
SDF-1-CXCR4, Ki: 1 μM
   
NUCC-390        
CXCR4
   
PS372424      
Human CXCR3
     
CTCE-0214        
SDF-1α-CXCR4
    98.94%
Mavorixafor        
125I-SDF-CXCR4, IC50: 13 nM
   
KRH-3955 hydrochloride        
SDF-1α-CXCR4, IC50: 0.61 nM
   
AMG 487 (S-enantiomer)      
CXCR3
      99.81%
FC131        
125I-SDF-CXCR4, IC50: 4.5 nM
   
SRT3109    
CXCR2, pIC50: 8.2
        99.82%
Balixafortide        
CXCR4, IC50: <10 nM
   
Elubrixin    
CXCR2
       
AZ10397767    
CXCR2, IC50: 1 nM
       
CXCR4 antagonist 7        
CXCR4/CXCL12, IC50: 9.3 nM
   
Peptide R        
CXCR4
   
CXCR2 antagonist 7    
CXCR2, IC50: 0.044 μM
       
CTCE-9908 TFA        
CXCR4
   
CXCR2 antagonist 6    
CXCR2, IC50: 0.43 μM
       
TC14012 TFA        
CXCR4, IC50: 19.3 nM (antagonist site)
CXCR7, EC50: 350 nM (agonist site)
 
Nicotinamide N-oxide (Standard)    
CXCR2
       
CXCR2 antagonist 5    
CXCR2, IC50: 0.013 μM
       
CXCR3 antagonist 1      
CXCR3, IC50: 0.06 μM
     
CXCR4 modulator-1        
CXCR4, EC50: 100 nM
   
CXCR4 antagonist 5        
CXCR4, IC50: 8.8 nM
   
CXCR4 antagonist 9        
CXCR4, IC50: 15 nM
   
CXCR4 antagonist 3        
CXCR4, IC50: 11 nM
   
CXCR4 antagonist 4        
CXCR4, IC50: 24 nM
   
TIQ-15        
CXCR4, IC50: 6 nM
   
ATI-2341        
CXCR4, EC50: 194 nM (in CCRF-CEM cells)
   
CXCR4 modulator-2        
CXCR4, IC50: 1.25 nM
   
CXCR4 antagonist 8        
CXCR4, IC50: 57 nM
   
Corydalmine    
CXCR2
       
Ac-Pro-Gly-Pro-OH    
CXCR2
       
CXCR4 antagonist 1        
CXCR4
   
BAM-12P          
CXCR7, EC50: 175 nM
 
HF50731        
CXCR4, IC50: 19.8 nM
   
ICT5040        
CXCR4, IC50: 3.8 μM
   
CXCR2 antagonist 4    
CXCR2, IC50: 0.13 μM
       
CXCR4 antagonist 6        
CXCR4, IC50: 79 nM
   
Mavorixafor hydrochloride        
125I-CXCL12-CXCR4, IC50: 13 nM