1. Apoptosis
    Immunology/Inflammation
    GPCR/G Protein
  2. Apoptosis
    CXCR

Baohuoside I (Synonyms: Icariin-II; Icariside-II)

Cat. No.: HY-N0011 Purity: 98.96%
Handling Instructions

Baohuoside I (Icariside-II) is a component of Epimedium koreanum; a regulator of CXCR4 expression as well as function in cervical cancer and breast cancer cells; Apoptosis inducer.

For research use only. We do not sell to patients.

Baohuoside I Chemical Structure

Baohuoside I Chemical Structure

CAS No. : 113558-15-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 158 In-stock
Estimated Time of Arrival: December 31
10 mg USD 144 In-stock
Estimated Time of Arrival: December 31
50 mg USD 576 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Baohuoside I (Icariside-II) is a component of Epimedium koreanum; a regulator of CXCR4 expression as well as function in cervical cancer and breast cancer cells; Apoptosis inducer. IC50 value: Target: CXCR4 expression regulator in vitro: Baohuoside I downregulated CXCR4 expression in a dose- and time-dependent manner in HeLa cells [1]. Treatment with a pharmacological proteasome and lysosomal inhibitors did not have a substantial effect on baohuoside I's ability to suppress CXCR4 expression [1]. Treatment with 50 μm IS resulted in an increased number of apoptotic cells mirrored by increases in cleaved caspase?9 and cleaved PARP. In addition, treatment with 50 μM Icariside-IIsignificantly inhibited the activation of the Janus kinase (JAK)STAT3 and mitogen-activated protein kinase (MAPK) ERK pathways, but promoted the activation of the PI3K?AKT pathway [2]. Treatment of A375 cells with IS resulted in an increased number of apoptotic cells ranging from 5.6% to 26.3% mirrored by increases in cleaved caspase-3 and a decrease in survivin expression. IS significantly inhibited the activation of the JAK-STAT3 and MAPK pathways but promoted an unsustained activation peak of the PI3K-AKT pathway [3]. Icariside-II in MCF7 cells produced a loss of mitochondrial membrane potential and release of cytochrome c and apoptosis-inducing factor (AIF), and activation of caspase-9 revealed the involvement of the intrinsic apoptosis pathway. In contrast, IcaS enhanced the expression level of Fas and the Fas-associated death domain (FADD), and activated caspase-8, suggesting the involvement of the extrinsic apoptosis pathway [4]. in vivo: IS administration (50 mg/kg) resulted in a 47.5% decreased tumor volume in A375 bearing mice. IS administration (50 mg/kg, 100 mg/kg) resulted in 41% and 49% decreased tumor volume in B16 bearing mice, respectively [3].

Solvent & Solubility
In Vitro: 

DMSO : ≥ 32 mg/mL (62.19 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9436 mL 9.7178 mL 19.4356 mL
5 mM 0.3887 mL 1.9436 mL 3.8871 mL
10 mM 0.1944 mL 0.9718 mL 1.9436 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

514.52

Formula

C₂₇H₃₀O₁₀

CAS No.

113558-15-9

SMILES

OC1=CC(O)=C2C(OC(C3=CC=C(OC)C=C3)=C(O[[email protected]](O[[email protected]@H](C)[[email protected]](O)[[email protected]]4O)[[email protected]@H]4O)C2=O)=C1C/C=C(C)\C

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Baohuoside I
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HY-N0011
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Baohuoside I

Cat. No.: HY-N0011