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Ulocuplumab

(Synonyms: BMS 936564; MDX 1338; Anti-Human CXCR4 Recombinant Antibody)
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Ulocuplumab (Anti-Human CXCR4 Recombinant Antibody/BMS-936564/MDX1338) is a fully human IgG4 anti-CXCR4 antibody. Ulocuplumab induces apoptosis and inhibits CXCL12 mediated CXCR4 activation-migration of chronic lymphocytic leukemia (CLL). Ulocuplumab exhibits antitumor activity in established tumors including acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL), and multiple myeloma xenograft models.

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  • Pureté: 99.90%
  • CAS No.: 1375830-34-4
  • Masse moléculaire:144.84 kDa
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    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Ulocuplumab
  • Experimental Validation Results for Ulocuplumab
  • Experimental Validation Results for Ulocuplumab
  • Ulocuplumab Chemical Structure
    Ulocuplumab Chemical Structure
CAS No.: 1375830-34-4
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Assay Types
  • 1/16

    Human IgG4 kappa

  • 1/16

    Immobilized Human CXCR4/CD184 (Full Length) Protein-VLP can bind Ulocuplumab. The EC50 for this effect is 36.64 ng/mL.

  • 1/16

    Flow cytometric analysis of 1.5×106 THP-1 cells with Ulocuplumab (HY-P99272, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa Isotype Control (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Ulocuplumab Chemical Structure
    1/16
  • Ulocuplumab
  • Immobilized Human CXCR4/CD184 (Full Length) Protein-VLP can bind Ulocuplumab. The EC50 for this effect is 36.64 ng/mL.
  • Flow cytometric analysis of 1.5×106 THP-1 cells with Ulocuplumab (HY-P99272, red). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. Alexa Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 (S228P) kappa Isotype Control (HY-P99003, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).