1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR
  3. Ladarixin

Ladarixin (Synonyms: DF 2156A free base)

Cat. No.: HY-19519
Handling Instructions

Ladarixin (DF 2156A free base) is an orally active, allosteric non-competitive and dual CXCR1 and CXCR2 antagonist. Ladarixin can be used for the research of COPD and asthma.

For research use only. We do not sell to patients.

Ladarixin Chemical Structure

Ladarixin Chemical Structure

CAS No. : 849776-05-2

Size Price Stock
Solution
10 mM * 1 mL in DMSO USD 220 Ask For Quote & Lead Time
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 220 Ask For Quote & Lead Time
Solid
5 mg USD 200 Ask For Quote & Lead Time
10 mg USD 350 Ask For Quote & Lead Time
25 mg USD 700 Ask For Quote & Lead Time

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Description

Ladarixin (DF 2156A free base) is an orally active, allosteric non-competitive and dual CXCR1 and CXCR2 antagonist. Ladarixin can be used for the research of COPD and asthma[1].

In Vitro

Ladarixin inhibits human polymorphonuclear leukocyte (PMN) migration to CXCL8 (IC50 at 0.7 nM)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ladarixin (10 mg/kg; p.o. once a day) reduces allergic airway inflammation in a model of single OVA exposure. Ladarixin reduces allergic airway inflammation, remodeling, and bronchial hyperreactivity in a model of chronic OVA exposure[1].
Ladarixin (10 mg/kg; p.o. once a day for 8 days) reduces pulmonary inflammation and fibrosis induced by bleomycin in mice[1].
Ladarixin (10 mg/kg; p.o. once a day for 3 days) protects mice from cigarette smoke-induced exacerbation of influenza-A infection[1].
Ladarixin is also effective in decreasing CXCL8-induced polymorphonuclear leukocyte infiltration in several animal models without a significant dose-related reduction in systemic neutrophil counts[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (cigarette smoke-induced exacerbation of Influenza-A infection model)[1]
Dosage: 10 mg/kg
Administration: P.o. once a day at days 2, 3 and 4 post-infection
Result: Significantly attenuated the exacerbation in lethality and respiratory changes noted in CSFlu group.
Clinical Trial
Molecular Weight

375.34

Formula

C₁₁H₁₂F₃NO₆S₂

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (266.43 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6643 mL 13.3213 mL 26.6425 mL
5 mM 0.5329 mL 2.6643 mL 5.3285 mL
10 mM 0.2664 mL 1.3321 mL 2.6643 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  50% PEG300    50% saline

    Solubility: 10 mg/mL (26.64 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (6.66 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.66 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.66 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Ladarixin
Cat. No.:
HY-19519
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