1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR
  3. Burixafor hydrobromide

Burixafor hydrobromide (Synonyms: TG-0054 hydrobromide)

Cat. No.: HY-19867A Purity: >98.0%
Handling Instructions

Burixafor hydrobromide (TG-0054 hydrobromide) is an orally bioavailable and potent antagonist of CXCR4 and a well water soluble anti-angiogenic drug that is of potential value in treating choroid neovascularization. Burixafor hydrobromide (TG-0054 hydrobromide) mobilizes mesenchymal stem cells, attenuates inflammation, and preserves cardiac systolic function in a porcine model of myocardial infarction.

For research use only. We do not sell to patients.

Burixafor hydrobromide Chemical Structure

Burixafor hydrobromide Chemical Structure

CAS No. : 1191450-19-7

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Based on 1 publication(s) in Google Scholar

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Description

Burixafor hydrobromide (TG-0054 hydrobromide) is an orally bioavailable and potent antagonist of CXCR4 and a well water soluble anti-angiogenic drug that is of potential value in treating choroid neovascularization[1]. Burixafor hydrobromide (TG-0054 hydrobromide) mobilizes mesenchymal stem cells, attenuates inflammation, and preserves cardiac systolic function in a porcine model of myocardial infarction[2].

IC50 & Target[1]

CXCR4

 

Clinical Trial
Molecular Weight

769.01

Formula

C₂₇H₅₁N₈O₃P.₅/₂HBr

CAS No.

1191450-19-7

SMILES

NC1=CC(N2CCN(CCP(O)(O)=O)CC2)=NC(NC[[email protected]]3CC[[email protected]](CNCCCNC4CCCCC4)CC3)=N1.[H]Br.[5/2]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (65.02 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3004 mL 6.5019 mL 13.0037 mL
5 mM 0.2601 mL 1.3004 mL 2.6007 mL
10 mM 0.1300 mL 0.6502 mL 1.3004 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

BurixaforTG-0054TG0054TG 0054CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsInhibitorinhibitorinhibit

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Burixafor hydrobromide
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