CXCR4 - C-X-C motif chemokine receptor 4 Gene

Also Known as FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; WHIMS; HSY3RR; NPYY3R; WHIMS1; D2S201E

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7852

About CXCR4

Cytogenetic location: 2q22.1 Genomic coordinates (GRCh38): 2:136,114,349-136,118,149 (from NCBI)

This gene has 7 transcripts (splice variants), 285 orthologues, 23 paralogues and is associated with 64 phenotypes. Biased expression in bone marrow (RPKM 479.2), lymph node (RPKM 201.0) and 9 other tissues.

Summary

This gene encodes a CXC Chemokine Receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast Cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

CXCR4 Products (6)

mRNA	Protein	Name
NM_001348060.2	NP_001334989.1	C-X-C chemokine receptor type 4 isoform e
NM_001348056.2	NP_001334985.1	C-X-C chemokine receptor type 4 isoform c
NM_001008540.2	NP_001008540.1	C-X-C chemokine receptor type 4 isoform a
NM_003467.3	NP_003458.1	C-X-C chemokine receptor type 4 isoform b
XM_047445802.1	XP_047301758.1	C-X-C chemokine receptor type 4 isoform X1
NM_001348059.2	NP_001334988.1	C-X-C chemokine receptor type 4 isoform d

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables C-C chemokine binding	IPI IPI: Inferred from physical interaction	25612609	GOA
enables C-X-C motif chemokine 12 receptor activity	IDA IDA: Inferred from direct assay	28978524	GOA
enables actin binding	IDA IDA: Inferred from direct assay	12421915	GOA
enables myosin light chain binding	IDA IDA: Inferred from direct assay	12421915	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10644702	GOA
enables ubiquitin binding	IDA IDA: Inferred from direct assay	20228059	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	19116316	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in CXCL12-activated CXCR4 signaling pathway	IDA IDA: Inferred from direct assay	28978524	GOA
involved in CXCL12-activated CXCR4 signaling pathway	IGI IGI: Inferred from genetic interaction	27693460	GOA
involved in CXCL12-activated CXCR4 signaling pathway	IMP IMP: Inferred from mutant phenotype	24912431	GOA
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	10644702	GOA
acts upstream of or within calcium-mediated signaling	IMP IMP: Inferred from mutant phenotype	19064997	GOA
involved in cellular response to cytokine stimulus	IDA IDA: Inferred from direct assay	21540189	GOA
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20023705	GOA
involved in positive regulation of macrophage migration inhibitory factor signaling pathway	IMP IMP: Inferred from mutant phenotype	19665027	GOA
involved in positive regulation of vasculature development	IMP IMP: Inferred from mutant phenotype	27693460	GOA
involved in regulation of cell adhesion	IDA IDA: Inferred from direct assay	19703720	GOA
involved in regulation of chemotaxis	IMP IMP: Inferred from mutant phenotype	19106094	GOA
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	15174142	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell leading edge	IDA IDA: Inferred from direct assay	12421915	GOA
located in cell surface	IDA IDA: Inferred from direct assay	10521508	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	10521508	GOA
colocalizes with early endosome	IDA IDA: Inferred from direct assay	24790097	GOA
located in early endosome	IDA IDA: Inferred from direct assay	21540189	GOA
located in late endosome	IDA IDA: Inferred from direct assay	21540189	GOA
colocalizes with lysosome	IDA IDA: Inferred from direct assay	24790097	GOA
located in lysosome	IDA IDA: Inferred from direct assay	21540189	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19665027	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	19665027	GOA
part of protein-containing complex	IMP IMP: Inferred from mutant phenotype	25612609	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CXCR4 Protein Structure

CXCR4_N

7tm_1

0
100
200
300
352 a.a.

Protein Preferred Names	Protein Names
C-X-C chemokine receptor type 4	CD184 antigen LPS-associated protein 3 SDF-1 receptor chemokine (C-X-C motif) receptor 4 fusin leukocyte-derived seven transmembrane domain receptor lipopolysaccharide-associated protein 3 neuropeptide Y receptor Y3 neuropeptide Y3 receptor seven transmembrane helix receptor seven-transmembrane-segment receptor, spleen stromal cell-derived factor 1 receptor

CXCR4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CXCR4	P61073	CXCR3	Homo sapiens	P49682	FRET	23170857
Intra	CXCR4	P61073	CXCR3	Homo sapiens	P49682	BRET	23170857
Intra	CXCR4	P61073	ACKR3	Homo sapiens	P25106	Anti Bait CoIP	21730065
Intra	CXCR4	P61073	ACKR3	Homo sapiens	P25106	Confocal	21730065
Intra	CXCR4	P61073	ACKR3	Homo sapiens	P25106	BRET	19380869
Intra	CXCR4	P61073	ACKR3	Homo sapiens	P25106	PLA	25775528
Intra	CXCR4	P61073	ACKR3	Homo sapiens	P25106	Anti Tag CoIP	21730065
Intra	CXCR4	P61073	ACKR3	Homo sapiens	P25106	PLA	29386406
Intra	CXCR4	P61073	CD164	Homo sapiens	Q04900	Anti Bait CoIP	24094005
Intra	CXCR4	P61073	CD74	Homo sapiens	P04233	IF	19665027
Intra	CXCR4	P61073	CD74	Homo sapiens	P04233	Anti Tag CoIP	19665027
Intra	CXCR4	P61073	CXCR5	Homo sapiens	P32302	Anti Bait CoIP	23773523
Intra	CXCR4	P61073	MYH9	Homo sapiens	P35579	Pull Down	12421915
Intra	CXCR4	P61073	MYH9	Homo sapiens	P35579	Anti Bait CoIP	12421915
Intra	CXCR4	P61073	MYH9	Homo sapiens	P35579	Confocal	12421915
Intra	CXCR4	P61073	DBN1	Homo sapiens	Q16643	Confocal	23926103
Intra	CXCR4	P61073	CCR5	Homo sapiens	P51681	Anti Tag CoIP	18632580
Intra	CXCR4	P61073	CCR5	Homo sapiens	P51681	BRET	18632580
Intra	CXCR4	P61073	TLR2	Homo sapiens	O60603	FRET	18765807
Intra	CXCR4	P61073	TLR2	Homo sapiens	O60603	Anti Tag CoIP	20802527
Cross	CXCR4	P61073	Dbn1	Rattus norvegicus	Q07266-1	Confocal	20215400
Cross	CXCR4	P61073	Dbn1	Rattus norvegicus	Q07266-1	Pull Down	20215400

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CXCR4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72159	CXCR4 Protein, Human (N-His-SUMO, C-Myc)	P61073-2 (P303-S352)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P72160	CXCR4 Protein, Human (GST)	P61073-2 (P303-S352)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P72674	CXCR4 Protein, Human (HEK293, Fc)	P61073-1 (M1-S46)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700546	CXCR4 Protein, Human (Cell-Free, His)	P61073-2 (M1-S356)	≥ 90%, as determined by reducing SDS-PAGE.

CXCR4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81089	CXCR4 Antibody	WB, IHC-P, IHC-F, ICC/IF, FC, ELISA	Human, Mouse, Rat
HY-P84972	CD184 Antibody (YA4664)

Related Diseases

Diseases	Alias
Osteogenic Sarcoma	Osteosarcoma OSRC Osteosarcoma, Somatic Neoplasms, Bone Tissue Bone Tissue Neoplasm Osteoid Sarcoma Skeletal Sarcoma Osteosarcoma Of Bone Bone Sarcoma
Leukemia, Acute Lymphoblastic	Acute Lymphoblastic Leukemia ALL Acute Lymphocytic Leukemia Leukemia, Acute Lymphocytic, Susceptibility To, 1 Acute Lymphoblastic Leukaemia Precursor Lymphoblastic Lymphoma/Leukemia Precursor Lymphoid Neoplasm Leukemia, Acute Lymphoblastic, Susceptibility To B-Cell Acute Lymphoblastic Leukemia Leukemia, Acute Lymphocytic 1 Acute Lymphocytic Leukaemia Acute Lymphoblastic Leukemia/Lymphoma All1 Childhood Acute Lymphoblastic Leukemia Leukemia Acute Lymphoblastic 1 Leukemia Acute Lymphoblastic B-Hyperdiploid Leukemia Acute Lymphocytic Leukemia Acute Lymphocytic 1 Leukemia B-Cell Acute Lymphoblastic Leukemia T-Cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic, 3 ALL3 Lymphoblastic Leukemia Acute Leukemia, Acute, Lymphoblastic Precursor Cell Lymphoblastic Leukemia Lymphoma Leukemia, Lymphocytic, Acute, L1 Leukemia, Acute Lymphoblastic, Susceptibility To, 3
Whim Syndrome 1	Whim Syndrome Whims Warts, Hypogammaglobulinemia, Infections, And Myelokathexis WHIMS1 Warts-Hypogammaglobulinemia-Infections-Myelokathexis Syndrome Warts, Hypogammaglobulinemia, Infections, And Myelokathexis Syndrome 1 Myelokathexis, Isolated Wilm Warts-Infections-Leukopenia-Myelokatexis Syndrome Warts, Hypogammaglobulinemia, Infections And Myelokathexis Syndrome 1
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Cryptogenic Fibrosing Alveolitis Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis
Stroke, Ischemic	Cerebral Infarction Stroke Ischemic Stroke Cerebrovascular Accident Cerebral Infarction, Susceptibility To Stroke, Ischemic, Susceptibility To Cerebral Infarct Ischemic Stroke, Susceptibility To Stroke, Susceptibility To Cva - Cerebral Infarction ISCHSTR Ischemic Cerebrovascular Accident
Vipoma	Wdha Syndrome Pancreatic Cholera Pancreatic Vipoma Verner-Morrison Syndrome Diarrheogenic Islet Cell Tumor Vip-Secreting Tumor Malignant Vasoactive Intestinal Peptide-Secreting Tumor Vasoactive Intestinal Peptide-Secreting Tumor Vip- Secreting Tumor Vipoma, Malignant Vipoma Syndrome Watery Diarrhea Syndrome Watery Diarrhea, Hypokalemia, And Achlorhydria Syndrome Vasoactive Intestinal Peptide Tumor Vasoactive Intestinal Peptide-Producing Tumor Watery Diarrhea-Hypokalemia-Achlorhydria Syndrome Malignant Vipoma
Disease By Infectious Agent	Infectious Disease Infectious Diseases
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Desmoplastic/Nodular Medulloblastoma Medulloblastoma With Extensive Nodularity Desmoplastic Medulloblastoma Medulloblastoma, Somatic Medulloblastoma, Desmoplastic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Mben Medulloblastoma Desmoplastic Neuroectodermal Tumors, Primitive Medulloblastomas Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Renal Cell Carcinoma, Nonpapillary	Renal Cell Carcinoma RCC Nonpapillary Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma Hypernephroma Adenocarcinoma Of Kidney Renal Carcinoma, Chromophobe, Somatic Clear Cell Carcinoma Of Kidney Clear-Cell Metastatic Renal Cell Carcinoma Clear Cell Renal Carcinoma Renal Cell Carcinoma, Somatic Conventional Renal Cell Carcinoma Conventional Renal Cell Carcinoma Renal Clear Cell Carcinoma Ccrcc Hereditary Clear Cell Renal Cell Carcinoma Carcinoma, Renal Cell Renal Cell Carcinoma, Clear Cell, Somatic Renal Cell Carcinoma, Clear Cell Clear Cell Kidney Carcinoma Clear Cell Rcc Cystic-Multilocular Variant Clear Cell Renal Cell Adenocarcinoma Hereditary Clear Cell Renal Cell Adenocarcinoma Common Renal Cell Carcinoma Crcc Renal Cell Carcinoma Non-Papillary Carcinoma Renal Cell Renal Cell Cancer Carcinoma, Renal Cell, Nonpapillary
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Severe Congenital Neutropenia	Congenital Neutropenia Neutropenia, Severe Congenital Congenital Agranulocytosis Infantile Genetic Agranulocytosis Kostmann Disease Kostmann'S Agranulocytosis Kostmann'S Syndrome Severe Infantile Genetic Neutropenia
Agammaglobulinemia	Hypogammaglobulinemia Ighm Mu Heavy Chain Deficiency Mu-Heavy Chain Disease Mu-Hcd Mu-Chain Disease
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Hematologic Cancer	Hematologic Neoplasm Hematologic Malignancies Hematologic Neoplasms Blood Cancer Hematologic Malignancy Hematological Tumors Hematopoietic And Lymphoid System Tumor Hematopoietic Cancer Hematopoietic Neoplasm Hematopoietic Tumors Malignant Hematopoietic Neoplasm Liquid Tumor Hematopoietic Neoplasms
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Nasopharyngeal Carcinoma	Malignant Neoplasm Of Nasopharynx Npc Nasopharyngeal Cancer Nasopharyngeal Carcinoma 1 Nasopharynx Carcinoma Nasopharyngeal Neoplasms Npca Carcinoma Of Nasopharynx Malignant Nasopharyngeal Tumor Nasopharynx Cancer Squamous Cell Carcinoma Of The Nasopharynx Nasopharyngeal Neoplasm Cancer Of Nasopharynx
Molluscum Contagiosum	Water Warts Molluscum Verrucosum
Encephalitis	Mumps Encephalitis Mumps Meningoencephalitis Herpes Simplex Neuroinvasion Herpetic Encephalitis Herpetic Encephalopathy Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis Encephalitis Due To Herpesviridae Encephalitis Due To Herpesvirus Herpes Encephalitis Herpesviral Encephalitis Herpes Simplex Encephalitis Hsv - [Herpes Simplex Virus] Encephalitis Herpes Virus Encephalitis Simian B Disease Simian B Disorder Encephalitis Nec Idiopathic Encephalitis
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Myelofibrosis	Primary Myelofibrosis Agnogenic Myeloid Metaplasia Idiopathic Myelofibrosis Myeloid Metaplasia Myelofibrosis With Myeloid Metaplasia Osteomyelofibrosis Megakaryocytic Myelosclerosis Myelosclerosis Chronic Idiopathic Myelofibrosis Myelofibrosis, Idiopathic Myelofibrosis With Myeloid Metaplasia, Somatic Myelofibrosis, Somatic Aleukemic Myelosis Bone Marrow Fibrosis MYELOF MMM Agnogenic Myeloid Metaplasia With Myelofibrosis Ammm Myelosclerosis With Myeloid Metaplasia Myelofibrosis Nos
Esophageal Cancer	Esophageal Carcinoma Carcinoma Of Esophagus Esophageal Squamous Cell Carcinoma, Somatic Esophageal Carcinoma, Somatic Esophagus Cancer Gastric Cardia Adenocarcinoma Esophageal Neoplasms Esophageal Cancer, Somatic Cancer Of Esophagus Cancer Of Oesophagus Carcinoma Of Oesophagus Ca Lower Third Oesophagus Ca Middle Third Oesophagus Malignant Neoplasm Of Distal Third Of Esophagus Malignant Neoplasm Of Lower Third Of Oesophagus Malignant Neoplasm Of Middle Third Of Oesophagus Malignant Neoplasm Of Proximal Third Of Esophagus Malignant Neoplasm Of Upper Third Esophagus Malignant Tumor Of Abdominal Esophagus Malignant Tumor Of Distal Third Of Esophagus Malignant Tumor Of Proximal Third Of Esophagus Malignant Tumor Of The Middle Third Of The Esophagus ESCR Aerodigestive Tract Cancer Escc Esophageal Squamous Cell Carcinoma Cancer, Esophageal Malignant Neoplasm Of Esophagus Squamous Cell Carcinoma Of Esophagus Malignant Neoplasm Of Middle Third Of Esophagus
Coronary Stenosis	Coronary Artery Stenosis
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Melanoma, Uveal	Uveal Melanoma Choroidal Melanoma Melanoma Of Uvea Iris Melanoma Malignant Melanoma Of Choroid Malignant Melanoma Of Iris
Mycobacterium Tuberculosis 1	Tuberculosis Tuberculosis, Susceptibility To Tuberculoma Mycobacterium Tuberculosis, Susceptibility To, 1 Mtbs1 TB
Inflammatory Bowel Disease 14	IBD14 Inflammatory Bowel Disease 14, Susceptibility To Bowel Disease, Inflammatory, Type 14
Vaccinia
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Dementia	Dementias Presenile Dementia Alzheimer Type Dementia Alzheimer Sclerosis Alzheimer Disease Dementia Alzheimer Dementia Primary Degenerative Alzheimer Type Dementia End Stage Alzheimer'S Dementia Alzheimer'S Type Atypical Dementia Alzheimer Type Presenile Dementia Early Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 2 Dementia In Alzheimer Disease With Early Onset Early Onset Alzheimer Type Dementia, Uncomplicated Primary Degenerative Alzheimer Type Dementia, Early Onset Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated Alzheimer Disease Dementia With Early Onset Presenile Sclerosis Presenile Brain Sclerosis Presenile Alzheimer Brain Sclerosis Late Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 1 Dementia In Alzheimer Disease With Late Onset Primary Degenerative Alzheimer Type Dementia, Late Onset Sdat - [Senile Dementia, Alzheimer Type] Alzheimer Disease Dementia With Late Onset Late Onset Alzheimer Brain Sclerosis Senile Alzheimer Brain Disease Senile Alzheimer Brain Sclerosis Senile Primary Degenerative Alzheimer Type Dementia Senile Dementia Of The Alzheimer Type Arteriosclerotic Dementia Strategic-Infarct Dementia Post Stroke Dementia Vascular Cognitive Impairment Vascular Dementia Dementia Of The Lewy Body Type Dementia With Lewy Bodies Sdlt - [Senile Dementia Of The Lewy Body Type] Senile Dementia Of The Lewy Body Type Alcohol-Related Dementia Alcoholic Dementia Nos Alcohol-Induced Dementia Alcoholic Brain Syndrome Chronic Alcoholic Brain Syndrome Alcohol Dementia Late Onset Alcoholic Psychosis Residual And Late-Onset Alcohol-Induced Psychotic Disorder Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder Late-Onset Psychoactive Substance-Induced Psychotic Disorder Inhalant Dementia Volatile Solvents Dementia Dementia In Paralysis Agitans Pdd - [Parkinson Disease Dementia] Dementia Syndrome Of Parkinson Disease Dementia In Parkinson Disease Parkinson Related Dementia Dementia In Huntington Chorea Hiv - [Human Immunodeficiency Virus] Dementia Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex Aids Related Dementia Dementia Due To Niacin Deficiency
Rhabdomyosarcoma
Prostatitis
Immune Deficiency Disease	Immunodeficiency Primary Immunodeficiency Disease Primary Immunodeficiency Immunologic Deficiency Syndromes Hypoimmunity Immune Deficiency Disorder Immunodeficiency Syndrome Immune Disorder Primary Immune Deficiency Disorder Immune System Diseases Human Immunodeficiency Virus Infection Hiv - [Human Immunodeficiency Virus Infection] Hiv Positive Nos Hiv Disease Acquired Immune Deficiency Syndrome-Related Complex Aids-Like Syndrome Aids-Related Complex Nos Arc - [Aids-Related Complex] Immunodeficiency Due To Human Immunodeficiency Virus Infection Unspecified Human Immunodeficiency Virus Disease Hiv Disease Nos Human Immunodeficiency Virus Positive Nos Hiv Nos Deficiency Of Complement Initial Pathway Deficiency Of Complement Terminal Pathway Cfdd - [Complement Factor D Deficiency] Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency Nonfamilial Hypogammaglobulinaemia Common Variable Immune Deficiency Nonfamilial Agammaglobulinaemia Common Variable Agammaglobulinaemia Agammaglobulinaemia Nos Agammaglobulinaemia Antibody Deficiency Syndrome Hypogammaglobulinaemia Antibody Deficiency Syndrome Acquired Agammaglobulinaemia Nos Hypogammaglobulinaemia Nos Hyper Igm
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Intraocular Lymphoma	Primary Intraocular Lymphoma Piol Primary Intraocular Non-Hodgkin Lymphoma Primary Intraocular Non-Hodgkin Malignant Lymphoma
High Grade Glioma	Malignant Glioma Glial Cell Tumor Glioma, Malignant Malignant Neuroglial Tumor Neuroglial Tumor Glioma Malignant Gliomas
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Head And Neck Cancer Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Cancer, Head/Neck Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Limb Ischemia
Brain Cancer	Malignant Neoplasm Of Brain Adult Brain Tumor Brain Neoplasms Brain Neoplasm Neoplasm Of Brain Primary Malignant Neoplasm Of Brain Brain Tumors Adult Malignant Brain Neoplasm Brain Neoplasm, Adult Bt - Brain Tumour Malignant Brain Tumour Malignant Primary Brain Neoplasm Malignant Primary Brain Tumor Malignant Tumor Of Adult Brain Malignant Tumor Of Brain Primary Brain Neoplasm Primary Brain Tumor Tumor Of The Brain Brain Tumor, Adult Brain Tumor Primary Malignant Primary Brain Tumors Primary Brain Tumors Cancer, Brain Brain Tumor, Primary
Hemangioblastoma	Capillary Hemangioblastoma
Human Immunodeficiency Virus Infectious Disease	Hiv Infections
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Disease, Susceptibility To Coronary Artery Anomaly Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Macroglobulinemia	Primary Macroglobulinemia Waldenstrom Macroglobulinemia
Plasma Protein Metabolism Disease
Pancreatic Cancer	Pancreatic Carcinoma Familial Pancreatic Carcinoma Pancreatic Neoplasm Carcinoma Of Pancreas Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Cancer Of The Pancreas Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Severe Combined Immunodeficiency	Scid Severe Combined Immunodeficiency Disease Combined T And B Cell Inborn Immunodeficiency Immunodeficiency, Severe Combined Scid - [Severe Combined Immunodeficiencies]
G6pc3 Deficiency	Ubiquitous Glucose-6-Phosphatase Deficiency
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
B-Lymphoblastic Leukemia/Lymphoma	B Lymphoblastic Leukemia/Lymphoma B-All Precursor B Lymphoblastic Lymphoma/Leukemia C-All Lymphoblastic Lymphoma, Nos Common Precursor B All Lymphoblastic B-Cell Lymphoma Pro-B All B-Precursor Lymphoma Lbl - [Lymphoblastic Lymphoma]
Myeloma, Multiple	Multiple Myeloma Kahler Disease Myelomatosis Plasma Cell Myeloma Medullary Plasmacytoma Multiple Myeloma, Resistance To Myeloma Plasma Cell Dyscrasia Multiple Myeloma, Susceptibility To Myeloma - Multiple Kahler'S Disease Kahler-Bozzolo Disease Plasma Cell Myelomas MM Plasma Cell Neoplasm Primary Systemic Amyloidosis Primary Amyloidosis Immunoglobulin Deposition Disease Plasmacytic Myeloma Multiple Myelomata Multiple Myeloma Nos Multiple Myeloma Without Mention Of Remission Monostotic Plasma Cell Myeloma Mm - [Multiple Myeloma]
Viral Infectious Disease	Arbovirus Infections Viral Disease Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Combined Immunodeficiency	Combined T Cell And B Cell Immunodeficiency Congenital Combined Immunodeficiency Syndrome With Combined Immunodeficiency Combined T And B Cell Immunodeficiency Combined Immunity Deficiency Combined Immunodeficiency Syndrome Combined T-Cell And B-Cell Immunodeficiency Lymphopenic Agammaglobulinaemia
Waldenstroem'S Macroglobulinemia	Waldenstrom Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstrom'S Macroglobulinaemia Waldenstrom'S Syndrome Waldenström Macroglobulinemia Waldenstrom'S Macroglobulinemia Wm Waldenström'S Macroglobulinemia Malignant Lymphoma - Lymphoplasmacytic
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Protection Against Lung Cancer, Susceptibility To Adenocarcinoma Of Lung, Somatic Nonsmall Cell Lung Cancer Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Pertussis	Whooping Cough Bordetella Infections Bordetella Infection Bordetella Pertussis Infection Wc - Whooping Cough Whooping Cough Due To Unspecified Organism Bordetellosis Tussis Convulsiva Whooping Cough, Unspecified Organism Wc - [Whooping Cough] Whooping Cough Due To B. Parapertussis Infection Due To Bordetella Parapertussis
Neutropenia	Leukopenia
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Mantle Cell Lymphoma	Lymphoma, Mantle Cell Lcm Mcl Mantle Zone Lymphoma Lymphoma Mantle-Cell Lymphoma, Mantle-Cell Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse Malignant Lymphoma - Lymphocytic, Intermediate Differentiation Diffuse Small Cleaved-Cell Lymphoma Diffuse Small Cleaved Cell Malignant Lymphoma Small Cleaved Cell Non-Hodgkin Lymphoma Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma Malignant Lymphomatous Polyposis Malignant Small Cell, Noncleaved, Diffuse Lymphoma Malignant Undifferentiated Cell, Non-Burkitt Lymphoma Cleaved Cell Lymphoma Small Cell Mantle Cell Lymphoma Small Cleaved Cell Malignant Lymphoma
Lymphoplasmacytic Lymphoma	Waldenstrom Macroglobulinemia Malignant Lymphoma - Lymphoplasmacytic Waldenström Macroglobulinaemia Waldenström Macroglobulinaemia Without Mention Of Remission Idiopathic Macroglobulinaemia Primary Macroglobulinaemia
Aids Dementia Complex	Adc Aids Related Cognitive Impairment
Sezary'S Disease	Sezary Syndrome Sézary Syndrome Sezary'S Lymphoma Sezary Disease Sezary Erythroderma Sezary Lymphoma
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Human Immunodeficiency Virus Type 1	Aids Hiv/Aids Aids, Delayed/Rapid Progression To Hiv-1, Susceptibility To Hiv-1 Viremia, Susceptibility To Human Immunodeficiency Virus Type 1, Susceptibility To Hiv-1 Aids, Slow Progression To Rapid Progression To Aids From Hiv1 Infection Hiv1 Infection, Resistance To Hiv1 Infection Hiv-1 Viremia Aids, Resistance To Aids, Rapid Progression To Hiv/Aids, Susceptibility To Hiv-1, Resistance To Hiv1, Resistance To Hiv1 Hiv-1 Disease, Delayed Progression Of Hiv-1 Disease, Rapid Progression Of Hiv Infection, Resistance To Hiv Type 1, Susceptibility To Hiv Type 1 Hiv-1 Infection Human Immunodeficiency Virus I Infection Acquired Immunodeficiency Syndrome Hiv-Infection/Aids

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-10046	Plerixafor	Antagonist	99.90%	Yes
HY-50912	Plerixafor octahydrochloride	Antagonist	98.03%	Yes
HY-P0171	Motixafortide	Antagonist	99.76%	Unkown
HY-50101A	Mavorixafor trihydrochloride	Antagonist	99.75%	Yes
HY-50101	Mavorixafor	Antagonist	99.72%	Yes
HY-50101C	Mavorixafor hydrochloride	Antagonist	99.64%	Unkown

Clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P1682A	Balixafortide TFA	Antagonist	99.89%	Phase 3
HY-P1682	Balixafortide	Antagonist	98.20%	Phase 3
HY-12488	LY2510924	Inhibitor	99.85%	Phase 2
HY-19867A	Burixafor hydrobromide	Antagonist	99.70%	Phase 2
HY-P1103	CTCE-9908	Antagonist	99.54%	Phase 2
HY-114244	USL311	Antagonist	99.97%	Phase 2
HY-19867	Burixafor	Antagonist	/	Phase 2
HY-13696	MSX-122	Antagonist	98.16%	Phase 1

Inhibitory Antibodies (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99272	Ulocuplumab	Antagonist	99.90%	Phase 3
HY-P991656	LY-2624587	Antagonist	/	Phase 1
HY-P991647	ALX-0651	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (57)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0011	Baohuoside I	Inhibitor	99.94%	Unkown
HY-W087028	NOTA-NHS ester		≥97.0%	Unkown
HY-101458A	IT1t dihydrochloride	Antagonist	99.77%	Unkown
HY-111793A	NUCC-390 dihydrochloride	Agonist	98.19%	Unkown
HY-P3612	CTCE-0214	Agonist	99.96%	Unkown
HY-P1104A	FC131 TFA	Antagonist	99.87%	Unkown
HY-15478	WZ811	Antagonist	99.80%	Unkown
HY-P1102	TC14012	Modulator	99.77%	Unkown
HY-D0976	NF279	Antagonist	98.5%	Unkown
HY-111793	NUCC-390	Agonist	98.01%	Unkown
HY-P10415	EPI-X4	Antagonist	98.91%	Unkown
HY-15971A	AMD 3465	Antagonist	98.24%	Unkown
HY-15971	AMD 3465 hexahydrobromide	Antagonist	98.0%	Unkown
HY-P7061A	ALX 40-4C Trifluoroacetate	Inhibitor	99.78%	Unkown
HY-122058A	KRH-3955 hydrochloride	Antagonist	/	Unkown
HY-161735	CXCR4-IN-3	Inhibitor	99.69%	Unkown
HY-167851	CCX662	Inhibitor	98.62%	Unkown
HY-P0172	ATI-2341	Agonist	99.64%	Unkown
HY-146413	HF50731	Antagonist	99.66%	Unkown
HY-147978	CXCR4 antagonist 8	Antagonist	99.88%	Unkown
HY-146372	CXCR4 antagonist 5	Antagonist	/	Unkown
HY-P4111A	Peptide R TFA	Antagonist	98.34%	Unkown
HY-P7061	ALX 40-4C	Inhibitor	/	Unkown
HY-P10971	Nef-M1	Antagonist	98.87%	Unkown
HY-146054	CXCR4 modulator-2	Modulator	/	Unkown
HY-P10973	Peptide R analogue 10	Antagonist	99.47%	Unkown
HY-103010	MSX-130	Antagonist	98.00%	Unkown
HY-P4111	Peptide R	Antagonist	/	Unkown
HY-168095	CXCR4 antagonist 10	Inhibitor	99.27%	Unkown
HY-P1104	FC131	Antagonist	/	Unkown
HY-101458	IT1t	Antagonist	/	Unkown
HY-147979	CXCR4 antagonist 9	Antagonist	/	Unkown
HY-P11011A	Peptide R54 acetate	Antagonist	99.88%	Unkown
HY-162632	Hit 14	Inhibitor	≥99.0%	Unkown
HY-103009	MSX-127	Antagonist	99.68%	Unkown
HY-183994	HL82624	Agonist	/	Unkown
HY-148640	WK500B	Activator	/	Unkown
HY-146401	CXCR4 antagonist 6	Antagonist	/	Unkown
HY-144286	CXCR4 antagonist 3	Inhibitor	/	Unkown
HY-P11019	IS4	Antagonist	/	Unkown
HY-129094	ICT5040	Antagonist	/	Unkown
HY-178205	BPRCX807	Antagonist	/	Unkown
HY-P11451	Pentixather		/	Unkown
HY-146053	CXCR4 modulator-1	Modulator	/	Unkown
HY-P1102A	TC14012 TFA	Modulator	/	Unkown
HY-P1103A	CTCE-9908 TFA	Antagonist	/	Unkown
HY-P11011	Peptide R54	Antagonist	/	Unkown
HY-P10427	DV1	Antagonist	/	Unkown
HY-136437	CXCR4 antagonist 1	Antagonist	/	Unkown
HY-182850	UCUF-965	Modulator	/	Unkown
HY-P10429	RCP168	Antagonist	/	Unkown
HY-177799	BPRCX 714	Antagonist	/	Unkown
HY-N9858	Herpetin	Activator	/	Unkown
HY-147808	CXCR4 antagonist 7	Antagonist	/	Unkown
HY-115493	TIQ-15	Antagonist	/	Unkown
HY-144285	CXCR4 antagonist 4	Antagonist	/	Unkown
HY-123819	KRH-1636	Antagonist	/	Unkown

Inhibitory Antibodies (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991568	AT009	Modulator	/	Unkown
HY-P991744	Anti-Mouse CXCR4 Antibody (Cx4Mab-1)		/	Unkown
HY-P992439	PF-06747143	Inhibitor	/	Unkown
HY-P992405	MEDI-3185	Antagonist	/	Unkown
HY-P992397	KY1051	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CXCR4	VGNC	VGNC:27856
Mus musculus	CXCR4	MGD	MGI:109563
Rattus norvegicus	CXCR4	RGD	RGD:620465
Felis catus	CXCR4	VGNC	VGNC:61299
Macaca mulatta	CXCR4	VGNC	VGNC:71572
Canis familiaris	CXCR4	VGNC	VGNC:39751
Others	CXCR4	NCBI