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DBN1 - drebrin 1 Gene

Also Known as D0S117E

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1627

About DBN1

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:177,456,610-177,473,634 (from NCBI)

This gene has 11 transcripts (splice variants), 199 orthologues and 4 paralogues. Ubiquitous expression in endometrium (RPKM 21.1), brain (RPKM 16.5) and 24 other tissues.

Summary

The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

DBN1 Products (7)

mRNA	Protein	Name
NM_001363541.2	NP_001350470.2	drebrin isoform c
NM_001364151.2	NP_001351080.2	drebrin isoform d
NM_001364152.2	NP_001351081.2	drebrin isoform e
NM_001393630.1	NP_001380559.1	drebrin isoform f
NM_001393631.1	NP_001380560.1	drebrin isoform g
NM_004395.4	NP_004386.3	drebrin isoform a
NM_080881.3	NP_543157.2	drebrin isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12577067	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cytoplasmic sequestering of protein	IDA IDA: Inferred from direct assay	28966017	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	8838578	GOA
located in cytoskeleton	IDA IDA: Inferred from direct assay	24327345	GOA
located in dendrite	IDA IDA: Inferred from direct assay	8838578	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DBN1 Protein Structure

Cofilin_ADF

0
100
200
300
400
500
600
649 a.a.

Protein Preferred Names	Protein Names
drebrin	developmentally-regulated brain protein

DBN1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DBN1	Q16643	AFDN	Homo sapiens	P55196	Anti Bait CoIP	23750010
Intra	DBN1	Q16643	AFDN	Homo sapiens	P55196	Confocal	23750010
Intra	DBN1	Q16643	GRB2	Homo sapiens	P62993	Y2H Array	25814554
Intra	DBN1	Q16643	GRB2	Homo sapiens	P62993	Lumier	25814554
Intra	DBN1	Q16643	CXCR4	Homo sapiens	P61073	Pull Down	20215400
Intra	DBN1	Q16643	CXCR4	Homo sapiens	P61073	Anti Bait CoIP	20215400
Intra	DBN1	Q16643	CXCR4	Homo sapiens	P61073	Anti Bait CoIP	23926103
Intra	DBN1	Q16643	PTEN	Homo sapiens	P60484	Anti Tag CoIP	23940795
Intra	DBN1	Q16643	PTEN	Homo sapiens	P60484	FRET	23940795
Intra	DBN1	Q16643	TINF2	Homo sapiens	Q9BSI4	Pull Down	21044950
Intra	DBN1	Q16643	TINF2	Homo sapiens	Q9BSI4	BiFC	21044950
Intra	DBN1	Q16643	ZMYND8	Homo sapiens	Q9ULU4	ITC	28966017
Intra	DBN1	Q16643	ZMYND8	Homo sapiens	Q9ULU4	X-Ray Diffraction	28966017
Intra	DBN1	Q16643	ZMYND8	Homo sapiens	Q9ULU4	GMS	28966017
Intra	DBN1	Q16643	ZMYND8	Homo sapiens	Q9ULU4	Confocal	28966017
Intra	DBN1	Q16643	DBN1	Homo sapiens	Q16643-1	Anti Tag CoIP	23750010

Cross: Cross-species interaction Intra: Intraspecies interaction

DBN1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83573	Drebrin Antibody (YA3318)	WB, ICC/IF, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Down Syndrome	Trisomy 21 Complete Trisomy 21 Syndrome Down'S Syndrome Trisomy 21 Syndrome Down'S Syndrome - Trisomy 21 Downs Syndrome G Trisomy 47,Xx,+21 47,Xy,+21 Trisomy G Down Syndrome, Susceptibility To Chromosome 21 Trisomy Trisomy 21 Nos Abnormal Autosomes 21
Dyskeratosis Congenita, Autosomal Recessive 2	DKCB2 Autosomal Recessive Dyskeratosis Congenita 2 Dyskeratosis Congenita, Autosomal Recessive, 2 Dyskeratosis Congenita, Autosomal Recessive, Type 2
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03548	DBN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21320	Dbn1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27839	Dbn1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DBN1	VGNC	VGNC:61347
Canis familiaris	DBN1	VGNC	VGNC:39783
Bos taurus	DBN1	VGNC	VGNC:27890
Rattus norvegicus	DBN1	RGD	RGD:70885
Mus musculus	DBN1	MGD	MGI:1931838
Macaca mulatta	DBN1	VGNC	VGNC:71742
Others	DBN1	NCBI