2. GPCR/G Protein Immunology/Inflammation
  3. CXCR
  4. ICT5040

ICT5040 is a small molecule CXCR4 antagonist (IC50=3.8 μM). ICT5040 inhibits CXCL12-mediated proliferation and migration, and suppresses CXCL12-induced intracellular calcium mobilisation in U87 glioma cells.

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ICT5040 Chemical Structure

ICT5040 Chemical Structure

CAS No. : 215655-21-3

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ICT5040 Related Antibodies

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Description

ICT5040 is a small molecule CXCR4 antagonist (IC50=3.8 μM). ICT5040 inhibits CXCL12-mediated proliferation and migration, and suppresses CXCL12-induced intracellular calcium mobilisation in U87 glioma cells[1].

IC50 & Target[1]

CXCR4

3.8 μM (IC50)

In Vitro

ICT5040 (1-100 μM; 0-4 d) dose-dependently inhibits CXCL12-induced proliferation and migration of U87-glioma cells[1].
ICT5040 reduces CXCL12-induced intracellular calcium mobilisation in U87 glioma cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ICT5040 Related Antibodies

Cell Migration Assay [1]

Cell Line: U87-glioma cells
Concentration: 1 μM, 10 μM, 100 μM; with 100 ng/mL CXCL12
Incubation Time: 0, 1, 2, 3, and 4 days
Result: Resulted reduction of CXCL12 induced proliferation and migration of U87 cells at day 3.
Molecular Weight

275.25

Formula

C10H8F3N3OS
CAS No.
SMILES

FC(C1=CC=C(C2=NN=C(SC)O2)C(C)=N1)(F)F
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Purity & Documentation
References
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ICT5040 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ICT5040215655-21-3ICT 5040ICT-5040CXCRCXC chemokine receptorsC-X-C motif chemokine receptorsInhibitorinhibitorinhibit

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