ICT5040
ICT5040 is a small molecule CXCR4 antagonist (IC50=3.8 μM). ICT5040 inhibits CXCL12-mediated proliferation and migration, and suppresses CXCL12-induced intracellular calcium mobilisation in U87 glioma cells.
For research use only. We do not sell to patients.
- CAS No.: 215655-21-3
- Formula: C10H8F3N3OS
- Molecular Weight:275.25
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
CXCR4 3.8 μM (IC50) |
ICT5040 (1-100 μM; 0-4 d) dose-dependently inhibits CXCL12-induced proliferation and migration of U87-glioma cells[1].
ICT5040 reduces CXCL12-induced intracellular calcium mobilisation in U87 glioma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:U87-glioma cells
-
Concentration:1 μM, 10 μM, 100 μM; with 100 ng/mL CXCL12
-
Incubation Time:0, 1, 2, 3, and 4 days
-
Result:Resulted reduction of CXCL12 induced proliferation and migration of U87 cells at day 3.
Chemical Information
-
CAS No. 215655-21-3
-
Molecular Weight 275.25
-
Formula C10H8F3N3OS
-
SMILES
FC(C1=CC=C(C2=NN=C(SC)O2)C(C)=N1)(F)F
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ICT5040 Related Classifications
HY-129094 Related Classifications
Powered by Bioz