1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR
  3. CXCR4 antagonist 6

CXCR4 antagonist 6 

Cat. No.: HY-146401
Handling Instructions

CXCR4 antagonist 6 (compound 46) is a potent CXCR4 antagonist with an IC50 value of 79 nM. CXCR4 antagonist 6 inhibits CXCL12 induced cytosolic calcium flux (IC50 = 0.25 nM). CXCR4 antagonist 6 significantly mitigates CXCL12/CXCR4 mediated cell migration. CXCR4 antagonist 6 exhibits marked efficacy in a cancer metastasis model in mice.

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CXCR4 antagonist 6 Chemical Structure

CXCR4 antagonist 6 Chemical Structure

CAS No. : 2304750-68-1

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Description

CXCR4 antagonist 6 (compound 46) is a potent CXCR4 antagonist with an IC50 value of 79 nM. CXCR4 antagonist 6 inhibits CXCL12 induced cytosolic calcium flux (IC50 = 0.25 nM). CXCR4 antagonist 6 significantly mitigates CXCL12/CXCR4 mediated cell migration. CXCR4 antagonist 6 exhibits marked efficacy in a cancer metastasis model in mice[1].

IC50 & Target[1]

CXCR4

79 nM (IC50)

Molecular Weight

366.50

Formula

C21H30N6

CAS No.
SMILES

CC1=CC=CN=C1[[email protected]@H]2CCCN2CC3=NC(C)=NC(N4CCN(CC4)C)=C3

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
CXCR4 antagonist 6
Cat. No.:
HY-146401
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