CXCR4 antagonist 6
CXCR4 antagonist 6 (compound 46) is a potent CXCR4 antagonist with an IC50 value of 79 nM. CXCR4 antagonist 6 inhibits CXCL12 induced cytosolic calcium flux (IC50 = 0.25 nM). CXCR4 antagonist 6 significantly mitigates CXCL12/CXCR4 mediated cell migration. CXCR4 antagonist 6 exhibits marked efficacy in a cancer metastasis model in mice.
For research use only. We do not sell to patients.
- CAS No.: 2304750-68-1
- Formula: C21H30N6
- Molecular Weight:366.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
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CXCR4 79 nM (IC50) |
Chemical Information
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CAS No. 2304750-68-1
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Molecular Weight 366.50
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Formula C21H30N6
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SMILES
CC1=CC=CN=C1[C@@H]2CCCN2CC3=NC(C)=NC(N4CCN(CC4)C)=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)