2304750-68-1
Chemical Structure
CXCR4 antagonist 6
- CAS No.: 2304750-68-1
- Formula:C21H30N6
- Molecular Weight:366.50
IUPAC Name: (S)-2-methyl-4-(4-methylpiperazin-1-yl)-6-((2-(3-methylpyridin-2-yl)pyrrolidin-1-yl)methyl)pyrimidine
InChIKey: SJRFKTBEMQHUCF-IBGZPJMESA-N
SMILES: CC1=CC=CN=C1[C@@H]2CCCN2CC3=NC(C)=NC(N4CCN(CC4)C)=C3
Biological Activity: CXCR4 antagonist 6 (compound 46) is a potent CXCR4 antagonist with an IC50 value of 79 nM. CXCR4 antagonist 6 inhibits CXCL12 induced cytosolic calcium flux (IC50 = 0.25 nM). CXCR4 antagonist 6 significantly mitigates CXCL12/CXCR4 mediated cell migration. CXCR4 antagonist 6 exhibits marked efficacy in a cancer metastasis model in mice[1].
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CXCR4 antagonist 6 | CXCR4 antagonist 6 (compound 46) is a potent CXCR4 antagonist with an IC50 value of 79 nM. CXCR4 antagonist 6 inhibits CXCL12 induced cytosolic calcium flux (IC50 = 0.25 nM). CXCR4 antagonist 6 significantly mitigates CXCL12/CXCR4 mediated cell migration. CXCR4 antagonist 6 exhibits marked efficacy in a cancer metastasis model in mice. | |||||||||||||||||||||
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Keywords
