DPM-1003
DPM-1003 is a modulator of protein tyrosine phosphatase 1B (PTP1B) and C-X-C chemokine receptor 4 (CXCR4). DPM-1003 binds to the non-catalytic disordered C-terminal fragment of PTP1B. DPM-1003 inhibits the PI3Kγ-mediated AKT/mTOR signaling pathway downstream of CXCR4. DPM-1003 improves the survival rate of mice in a transfusion-related acute lung injury model, and exerts a lung injury protective effect in preclinical mouse models of acute lung injury and sepsis. DPM-1003 can be used in research related to acute lung injury, acute respiratory distress syndrome, transfusion-related acute lung injury and sepsis.
For research use only. We do not sell to patients.
- CAS No.: 3018836-86-4
- Formula: C35H57N3O3
- Molecular Weight:567.85
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PTP1B |
DPM-1003 (4 μM) inhibits PMA-induced AKT phosphorylation in mouse bone marrow-derived neutrophils in vitro[1].
DPM-1003 (2-4 μM) selectively inhibits the PI3Kγ-mediated AKT signaling pathway downstream of CXCR4 in ex vivo models of mouse bone marrow-derived neutrophils and HL-60 promyelocytes, while exerting no significant effect on HeLa cells[1].
DPM-1003 (4 μM) inhibits the migration of mouse primary neutrophils toward the CXCR4 ligand CXCL12 in vitro[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
DPM-1003 (single dose) induces an aged-neutrophil phenotype in healthy mice, characterized by neutrophilia, reduced granule content, and downregulation of fresh neutrophil surface markers[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c mice (TRALI model induced by LPS priming followed by anti-MHC-I antibody injection)[1]
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Dosage:5.0 mg/kg; 20 mg/kg
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Administration:i.p.; single dose
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Result:Achieved 80% mouse survival at 120 minutes post TRALI induction.
Achieved 100% mouse survival at 120 minutes post TRALI induction.
Chemical Information
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CAS No. 3018836-86-4
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Molecular Weight 567.85
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Formula C35H57N3O3
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SMILES
O[C@H]1[C@]2([H])[C@@](CC[C@]3([C@@]2([H])CC[C@]3([H])[C@H](C)CCC(OC)=O)C)([H])[C@@]4([C@@](CC(CC4)NCCCCNCC5=CN=CC=C5)([H])C1)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DPM-1003 Related Classifications
HY-160550 Related Classifications
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