1. GPCR/G Protein
    Immunology/Inflammation
  2. CXCR
  3. USL311

USL311 

Cat. No.: HY-114244 Purity: 99.97%
Handling Instructions

USL311 is a selective CXCR4 antagonist, with anti-tumor activity. USL311 prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4.

For research use only. We do not sell to patients.

USL311 Chemical Structure

USL311 Chemical Structure

CAS No. : 1373268-67-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 275 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 850 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

USL311 is a selective CXCR4 antagonist, with anti-tumor activity. USL311 prevents the binding of stromal-cell derived factor-1 (SDF-1 or CXCL12) to CXCR4[1].

IC50 & Target[1]

CXCR4

 

Clinical Trial
Molecular Weight

422.57

Formula

C₂₄H₃₄N₆O

CAS No.

1373268-67-7

SMILES

O=C(C1=NC(N2CCN(C3CCN(C(C)C)CC3)CCC2)=CC=C1)NC4=CC=NC=C4

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (59.16 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3665 mL 11.8324 mL 23.6647 mL
5 mM 0.4733 mL 2.3665 mL 4.7329 mL
10 mM 0.2366 mL 1.1832 mL 2.3665 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.92 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.92 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.92 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.97%

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Product Name:
USL311
Cat. No.:
HY-114244
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