Herpetin
Herpetin is an active lignan. Herpetin acts as a bone marrow mesenchymal stem cell inducer that activates the SDF-1/CXCR4 axis and the Wnt/β-catenin pathway. Herpetin is applicable to research related to acute liver injury.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 911052-87-4
- 화학식: C30H34O9
- 분자량:538.59
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
|
CXCR4 |
Herpetin (10-100 μM; 24-72 h) reduces the viability of mouse bone marrow mesenchymal stem cells (BMSCs) in a concentration-dependent manner within the range of 25-100 μM, while 10 μM Herpetin exerts no significant cytotoxic effect on mouse BMSCs[1].
Herpetin (10 μM; 7-21 d) promotes the differentiation of mouse bone marrow mesenchymal stem cells (BMSCs) into hepatocyte-like cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:passage 3-5 mouse bone marrow mesenchymal stem cells (BMSCs)
-
Concentration:10, 25, 50, 75, 100 μM
-
Incubation Time:24, 48, 72 h
-
Result:Significantly reduced BMSC viability at 25, 50, 75, 100 μM after 24, 48, and 72 h.
Showed no significant effect on BMSC viability at 10 μM across all tested time points.
-
Cell Line:passage 3-5 mouse bone marrow mesenchymal stem cells (BMSCs)
-
Concentration:10 μM
-
Incubation Time:7, 14, 21 d
-
Result:Significantly increased relative CYP3A4 fluorescence intensity compared to untreated BMSCs at 7, 14, and 21 d.
Significantly increased glycogen storage in BMSCs compared to untreated BMSCs at 14 and 21 d; no significant difference was observed at 7 d.
Increased alpha-fetoprotein (AFP), albumin (ALB), and cytokeratin 18 (CK18) expression compared to untreated BMSCs, with statistically significant increases at 14 and 21 d and non-significant increases at 7 d.
Peaked AFP expression at 14 d then decreased, while ALB and CK18 expression increased continuously from 7 to 21 d.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57BL/6 (male, 6-8 weeks of age)[1]
-
Dosage:20 mg/kg
-
Administration:i.p.; single dose (administered 8 hours post-liver injury induction)
-
Result:Reduced serum AST levels compared to the model group.
Reduced the liver histopathological severity score compared to the model group.
Elevated liver tissue expression of SDF-1, CXCR4, p-GSK-3β, and β-catenin compared to the model group.
Improved mouse survival rate compared to the model group.
Chemical Information
-
CAS No. 911052-87-4
-
분자량 538.59
-
화학식 C30H34O9
-
SMILES
C(O)[C@H]1C=2C(O[C@@H]1C3=CC(OC)=C(O)C=C3)=CC(C[C@H]4[C@@H](CO)[C@@H](OC4)C5=CC(O)=C(OC)C=C5)=CC2OC
-
Structure Classification
-
Initial Source
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. Ding Y, et al. Herpetin Promotes Bone Marrow Mesenchymal Stem Cells to Alleviate Carbon Tetrachloride-Induced Acute Liver Injury in Mice. Molecules. 2023;28(9):3842. Published 2023 May 1. [Content Brief]
[2]. Cong LB, et al. Simultaneous determination of seven bioactive lignans in Herpetospermum caudigerum by RP-HPLC method. Biomed Chromatogr. 2008;22(10):1084-1090. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Herpetin Related Classifications
HY-N9858 Related Classifications
Powered by Bioz
- Herpetin
- 911052-87-4
- CXCR
- Wnt
- β-catenin
- SDF-1/CXCR4 axis
- bone marrow mesenchymal stem cells
- carbon tetrachloride-induced acute liver injury mice
- Wnt/β-catenin pathway
- Herpetospermum caudigerum Wall.
- albumin
- alpha-fetoprotein
- cytokeratin 18
- cytochrome P450 family 3 subfamily a member 4
- hepatocyte-like cells
- Inhibitor
- inhibitor
- inhibit