2. GPCR/G Protein Immunology/Inflammation Stem Cell/Wnt
  3. CXCR Wnt β-catenin
  4. Herpetin

Herpetin is an active lignan. Herpetin acts as a bone marrow mesenchymal stem cell inducer that activates the SDF-1/CXCR4 axis and the Wnt/β-catenin pathway. Herpetin is applicable to research related to acute liver injury.

For research use only. We do not sell to patients.

Herpetin

Herpetin Chemical Structure

CAS No. : 911052-87-4

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Herpetin Related Antibodies

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Description

Herpetin is an active lignan. Herpetin acts as a bone marrow mesenchymal stem cell inducer that activates the SDF-1/CXCR4 axis and the Wnt/β-catenin pathway. Herpetin is applicable to research related to acute liver injury[1][2].

IC50 & Target[1]

CXCR4

 

In Vitro

Herpetin (10-100 μM; 24-72 h) reduces the viability of mouse bone marrow mesenchymal stem cells (BMSCs) in a concentration-dependent manner within the range of 25-100 μM, while 10 μM Herpetin exerts no significant cytotoxic effect on mouse BMSCs[1].
Herpetin (10 μM; 7-21 d) promotes the differentiation of mouse bone marrow mesenchymal stem cells (BMSCs) into hepatocyte-like cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Herpetin Related Antibodies

Cell Viability Assay[1]

Cell Line: passage 3-5 mouse bone marrow mesenchymal stem cells (BMSCs)
Concentration: 10, 25, 50, 75, 100 μM
Incubation Time: 24, 48, 72 h
Result: Significantly reduced BMSC viability at 25, 50, 75, 100 μM after 24, 48, and 72 h.
Showed no significant effect on BMSC viability at 10 μM across all tested time points.

Cell Differentiation Assay[1]

Cell Line: passage 3-5 mouse bone marrow mesenchymal stem cells (BMSCs)
Concentration: 10 μM
Incubation Time: 7, 14, 21 d
Result: Significantly increased relative CYP3A4 fluorescence intensity compared to untreated BMSCs at 7, 14, and 21 d.
Significantly increased glycogen storage in BMSCs compared to untreated BMSCs at 14 and 21 d; no significant difference was observed at 7 d.
Increased alpha-fetoprotein (AFP), albumin (ALB), and cytokeratin 18 (CK18) expression compared to untreated BMSCs, with statistically significant increases at 14 and 21 d and non-significant increases at 7 d.
Peaked AFP expression at 14 d then decreased, while ALB and CK18 expression increased continuously from 7 to 21 d.
In Vivo

Herpetin (20 mg/kg; i.p.; single dose) ameliorates carbon tetrachloride (HY-Y0298)-induced acute liver injury in mice by reducing serum AST levels, alleviating hepatic histopathological damage, activating the SDF-1/CXCR4 axis and Wnt/β-catenin pathway, and increasing survival rate[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (male, 6-8 weeks of age)[1]
Dosage: 20 mg/kg
Administration: i.p.; single dose (administered 8 hours post-liver injury induction)
Result: Reduced serum AST levels compared to the model group.
Reduced the liver histopathological severity score compared to the model group.
Elevated liver tissue expression of SDF-1, CXCR4, p-GSK-3β, and β-catenin compared to the model group.
Improved mouse survival rate compared to the model group.
Molecular Weight

538.59

Formula

C30H34O9
CAS No.
SMILES

C(O)[C@H]1C=2C(O[C@@H]1C3=CC(OC)=C(O)C=C3)=CC(C[C@H]4[C@@H](CO)[C@@H](OC4)C5=CC(O)=C(OC)C=C5)=CC2OC
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Herpetin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Herpetin911052-87-4CXCRWntβ-cateninCXC chemokine receptorsC-X-C motif chemokine receptorsBeta cateninSDF-1/CXCR4 axisbone marrow mesenchymal stem cellscarbon tetrachloride-induced acute liver injury miceWnt/β-catenin pathwayHerpetospermum caudigerum Wall.albuminalpha-fetoproteincytokeratin 18cytochrome P450 family 3 subfamily a member 4hepatocyte-like cellsInhibitorinhibitorinhibit

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