Wnt2
Wnt2 functions within the Wnt/β-catenin signaling system, a conserved pathway that regulates development, adult tissue stem cells, and growth-related disease processes[1]. Mechanistically, Wnt2/2b signaling through canonical β-catenin specifies lung endoderm progenitors in the anterior foregut, and pathway activation can reprogram esophagus and stomach endoderm toward lung progenitor fate[2]. In lung mesenchyme, Wnt2 activates the airway smooth muscle program by regulating myocardin/Mrtf-B and Fgf10 expression[3]. In colorectal cancer cells, Wnt2 is highly expressed, co-expressed with Wnt/β-catenin target genes, and required for target-gene expression and cell proliferation[4]. Compared with related isoforms, WNT2B is a WNT2 paralogue that encodes WNT2B1 and WNT2B2 through alternative splicing and alternative promoter usage[5]. For experimental applications, Wnt2 loss-of-function, Wnt2 neutralization, β-catenin deletion, Dkk1 expression, and multi-Frizzled antibody blockade provide practical approaches to test ligand-dependent Wnt signaling in developmental and cancer models[2][4][6].
References:
- [1]. Nusse R, et al. Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities. Cell. 2017 Jun 1;169(6):985-999. [Content Brief]
- [2]. Goss AM, et al. Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut. Dev Cell. 2009 Aug;17(2):290-8. [Content Brief]
- [3]. Paix A, et al. Bi-polarized translation of ascidian maternal mRNA determinant pem-1 associated with regulators of the translation machinery on cortical Endoplasmic Reticulum (cER). Dev Biol. 2011 Sep 1;357(1):211-26. [Content Brief]
- [4]. Jung YS, et al. Wnt2 complements Wnt/β-catenin signaling in colorectal cancer. Oncotarget. 2015 Nov 10;6(35):37257-68. [Content Brief]
- [5]. Katoh M. Differential regulation of WNT2 and WNT2B expression in human cancer. Int J Mol Med. 2001 Dec;8(6):657-60. doi: 10.3892/ijmm.8.6.657. PMID: 11712082. et al. Differential regulation of WNT2 and WNT2B expression in human cancer. Int J Mol Med. 2001 Dec;8(6):657-60. [Content Brief]
- [6]. Zhang Y, et al. Canonical wnt signaling is required for pancreatic carcinogenesis. Cancer Res. 2013 Aug 1;73(15):4909-22. [Content Brief]
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BIM-46174
0 ImagesCat. No.: HY-183400CAS No.: 195450-11-4BIM-46174 is a heterotrimeric G protein complex inhibitor. BIM-46174 blocks GPCR downstream signaling by trapping Gα proteins in a nucleotide-free pocket conformation, thereby inhibiting Gαq-mediated calcium release, Gαs-mediated cAMP production, and GPCR-regulated cancer cell invasion. In vitro, BIM-46174 effectively suppresses a variety of clinically multidrug-resistant cell lines and induces tumor cell apoptosis through activation of caspase-3 and PARP cleavage. BIM-46174 also inhibits activation of the Neu1-MMP-9-GPCR signaling platform and downstream NF-κB signaling, and is widely used in the study of cancer signaling pathways and inflammation-related research, including lung cancer, pancreatic cancer, breast cancer, melanoma, and leukemia.
