2. Signaling Pathways
  3. Stem Cell/Wnt
  4. Wnt
  5. Wnt2 Isoform

Wnt2

Wnt2 functions within the Wnt/β-catenin signaling system, a conserved pathway that regulates development, adult tissue stem cells, and growth-related disease processes[1]. Mechanistically, Wnt2/2b signaling through canonical β-catenin specifies lung endoderm progenitors in the anterior foregut, and pathway activation can reprogram esophagus and stomach endoderm toward lung progenitor fate[2]. In lung mesenchyme, Wnt2 activates the airway smooth muscle program by regulating myocardin/Mrtf-B and Fgf10 expression[3]. In colorectal cancer cells, Wnt2 is highly expressed, co-expressed with Wnt/β-catenin target genes, and required for target-gene expression and cell proliferation[4]. Compared with related isoforms, WNT2B is a WNT2 paralogue that encodes WNT2B1 and WNT2B2 through alternative splicing and alternative promoter usage[5]. For experimental applications, Wnt2 loss-of-function, Wnt2 neutralization, β-catenin deletion, Dkk1 expression, and multi-Frizzled antibody blockade provide practical approaches to test ligand-dependent Wnt signaling in developmental and cancer models[2][4][6].

Wnt2 Related Products (1):

Cat. No. Product Name Effect Purity
  • HY-183400
    BIM-46174
    		Inhibitor
    BIM-46174 is a heterotrimeric G protein complex inhibitor. BIM-46174 blocks GPCR downstream signaling by trapping Gα proteins in a nucleotide-free pocket conformation, thereby inhibiting Gαq-mediated calcium release, Gαs-mediated cAMP production, and GPCR-regulated cancer cell invasion. In vitro, BIM-46174 effectively suppresses a variety of clinically multidrug-resistant cell lines and induces tumor cell apoptosis through activation of caspase-3 and PARP cleavage. BIM-46174 also inhibits activation of the Neu1-MMP-9-GPCR signaling platform and downstream NF-κB signaling, and is widely used in the study of cancer signaling pathways and inflammation-related research, including lung cancer, pancreatic cancer, breast cancer, melanoma, and leukemia.