2. Signaling Pathways
  3. Stem Cell/Wnt
  4. Wnt
  5. Wnt2 Isoform
  6. Wnt2 Inhibitor

Wnt2 Inhibitor

Wnt2 Inhibitor (1):

Cat. No. Product Name Effect Purity
  • HY-183400
    BIM-46174
    		Inhibitor
    BIM-46174 is a heterotrimeric G protein complex inhibitor. BIM-46174 blocks GPCR downstream signaling by trapping Gα proteins in a nucleotide-free pocket conformation, thereby inhibiting Gαq-mediated calcium release, Gαs-mediated cAMP production, and GPCR-regulated cancer cell invasion. In vitro, BIM-46174 effectively suppresses a variety of clinically multidrug-resistant cell lines and induces tumor cell apoptosis through activation of caspase-3 and PARP cleavage. BIM-46174 also inhibits activation of the Neu1-MMP-9-GPCR signaling platform and downstream NF-κB signaling, and is widely used in the study of cancer signaling pathways and inflammation-related research, including lung cancer, pancreatic cancer, breast cancer, melanoma, and leukemia.