Wnt5
Wnt5a is a noncanonical Wnt ligand that controls tissue morphogenesis through Wnt5a-Ror-Dishevelled signaling[1]. Mechanistically, Wnt gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2, linking Wnt5a signaling to directional tissue organization[2]. Wnt5a also uses CD146 as a receptor to regulate cell migration and zebrafish embryonic convergent extension[3]. In disease models, Wnt5a signaling directly affects metastatic melanoma cell motility and invasion, supporting its use in cancer invasion studies[4]. Compared with related WNT5A isoforms, WNT5A-long inhibits proliferation, whereas WNT5A-short increases proliferation in cancer models[5]. Compared with Wnt5b, Wnt5a coordinates chondrocyte proliferation and differentiation through distinct regulation of cyclin D1 and p130 expression[6]. For experimental applications, Box5, a Wnt5a-derived hexapeptide, antagonizes Wnt5a-dependent melanoma cell migration and invasion by inhibiting Wnt5a-induced PKC and Ca2+ signaling[7].
References:
- [1]. Ho HY, et al. Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4044-51. [Content Brief]
- [2]. From the American Association of Neurological Surgeons (AANS), et al. Multisociety Consensus Quality Improvement Revised Consensus Statement for Endovascular Therapy of Acute Ischemic Stroke. Int J Stroke. 2018 Aug;13(6):612-632. [Content Brief]
- [3]. Ye Z, et al. Wnt5a uses CD146 as a receptor to regulate cell motility and convergent extension. Nat Commun. 2013;4:2803. [Content Brief]
- [4]. Weeraratna AT, et al. Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma. Cancer Cell. 2002 Apr;1(3):279-88. [Content Brief]
- [5]. Bauer M, et al. WNT5A encodes two isoforms with distinct functions in cancers. PLoS One. 2013 Nov 18;8(11):e80526. [Content Brief]
- [6]. Yang Y, et al. Wnt5a and Wnt5b exhibit distinct activities in coordinating chondrocyte proliferation and differentiation. Development. 2003 Mar;130(5):1003-15. [Content Brief]
- [7]. Jenei V, et al. A t-butyloxycarbonyl-modified Wnt5a-derived hexapeptide functions as a potent antagonist of Wnt5a-dependent melanoma cell invasion. Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19473-8. [Content Brief]
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Wnt5 Related Products (7)
Related Products (7)
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Zilovertamab
0 ImagesSynonyms: UC-961; Cirmtuzumab
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Foxy-5
0 ImagesFoxy-5, a WNT5A agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells. Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model.
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Box5 TFA
0 ImagesCat. No.: HY-123071APurity: 99.50%Box5 TFA is a potent Wnt5a antagonist. Box5 TFA inhibits Wnt5a signaling and inhibits Wnt5a-mediated Ca2+ release. Box5 TFA inhibits cell migration. Box5 TFA has the potential for the research of melanoma.
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Foxy-5 TFA
0 ImagesCat. No.: HY-P1416APurity: 99.17%Foxy-5 TFA, a WNT5A agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 TFA triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells. Foxy-5 TFA effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model.
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γ-Glutamylvaline
0 Imagesγ‑Glutamylvaline (γ-Glu-Val) is a calcium‑sensing receptor (CaSR) agonist. γ‑Glutamylvaline activates CaSR and facilitates its binding to β‑arrestin 2 to modulate inflammatory and metabolic homeostasis signaling. γ‑Glutamylvaline inhibits TNF‑α‑induced IL‑6/MCP‑1 and enhances adiponectin/PPARγ in adipocytes. γ‑Glutamylvaline upregulates Wnt5a, restores β‑catenin phosphorylation, and reduces serine‑phosphorylated IRS‑1 in adipocytes. γ-Glutamylvaline can be used for the research of low-grade chronic inflammation.
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MDGCEL
0 ImagesCat. No.: HY-P5171CAS No.: 881188-48-3MDGCEL is a WNT5A peptide, that acts as a WNT5A mimicks and exhibits WNT5A antagonistic activity.
