1224844-38-5
Chemical Structure
Sapanisertib
Synonym(s): INK-128; MLN0128; TAK-228
- CAS No.: 1224844-38-5
- Formula:C15H15N7O
- Molecular Weight:309.33
IUPAC Name: 5-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)benzo[d]oxazol-2-amine
InChIKey: GYLDXIAOMVERTK-UHFFFAOYSA-N
SMILES: NC1=NC=NC2=C1C(C3=CC4=C(C=C3)OC(N)=N4)=NN2C(C)C
Biological Activity: Sapanisertib (INK-128; MLN0128; TAK-228) is an orally active dual mTORC1/mTORC2 inhibitor. Sapanisertib directly and simultaneously inhibits mTORC1/2 activity through competitive binding with ATP, thereby comprehensively blocking downstream processes such as protein and lipid synthesis and cytoskeletal reorganization, consequently suppressing tumor cell proliferation and promoting apoptosis. Sapanisertib is applicable to research on melanoma, ovarian cancer, pulmonary fibrosis, and hematological malignancies[1][2][3][4][5].
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Sapanisertib | 99.78% | Sapanisertib (INK-128; MLN0128; TAK-228) is an orally active dual mTORC1/mTORC2 inhibitor. Sapanisertib directly and simultaneously inhibits mTORC1/2 activity through competitive binding with ATP, thereby comprehensively blocking downstream processes such as protein and lipid synthesis and cytoskeletal reorganization, consequently suppressing tumor cell proliferation and promoting apoptosis. Sapanisertib is applicable to research on melanoma, ovarian cancer, pulmonary fibrosis, and hematological malignancies. | ||||||||||||||||||||
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Sapanisertib (Standard) | ≥98% | Sapanisertib (INK-128; MLN0128; TAK-228) Standard is the analytical standard of Sapanisertib (HY-13328). This product is intended for research and analytical applications. Sapanisertib (INK-128; MLN0128; TAK-228) is an orally active dual mTORC1/mTORC2 inhibitor. Sapanisertib directly and simultaneously inhibits mTORC1/2 activity through competitive binding with ATP, thereby comprehensively blocking downstream processes such as protein and lipid synthesis and cytoskeletal reorganization, consequently suppressing tumor cell proliferation and promoting apoptosis. Sapanisertib is applicable to research on melanoma, ovarian cancer, pulmonary fibrosis, and hematological malignancies. | ||||||||||||||||||||
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References
- [1]. Wei BR, et al. Efficacy, Tolerability, and Pharmacokinetics of Combined Targeted MEK and Dual mTORC1/2 Inhibition in a Preclinical Model of Mucosal Melanoma. Mol Cancer Ther. 2020 Nov;19(11):2308-2318.
- [2]. Xu Z, et al. Sapanisertib attenuates pulmonary fibrosis by modulating Wnt5a/mTOR signalling. Basic & clinical pharmacology & toxicology. 2023 Sep;133(3):226-236.
- [3]. Hussein AM, et al. Metabolic Control over mTOR-Dependent Diapause-like State. Developmental cell. 2020 Jan 27;52(2):236-250.e7. [Content Brief]
- [4]. Zervantonakis IK, et al. Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response. Nature communications. 2017 Aug 28;8(1):365.
- [5]. Akça E S, et al. Inhibition of mTORC1/2 by INK-128 Impairs in vitro Oocyte Maturation in Mice[J]. Yeditepe Journal of Health Sciences, 2025, 3: 130-138.
