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Cat. No.: HY-P99201

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Biologically Validated

Zilovertamab

(Synonyms: UC-961; Cirmtuzumab)

2 Cited Publications

Customer Review

Based on 2 publication(s) in Google Scholar

Zilovertamab (UC-961) is a humanised monoclonal antibody against ROR1 that blocks Wnt5a-induced ROR1 signalling.

For research use only. We do not sell to patients.

Purity: 98.21%
CAS No.: 2485779-13-1
Molecular Weight:145.12 kDa

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Zilovertamab Chemical Structure

CAS No.: 2485779-13-1

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Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Clinical Trial
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Application
- Verified Bioactivity
Chemical Information
Publications (2)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Zilovertamab (UC-961) is a humanised monoclonal antibody against ROR1 that blocks Wnt5a-induced ROR1 signalling^[1].

Isotype

Human IgG1 kappa

Recommend Isotype Controls

Human IgG1 kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

Wnt5A

All ROR Isoforms :

All Wnt Isoforms :

In Vitro

Zilovertamab (25 and 50 μg/mL; 72 h) inhibits high-grade serous ovarian cancer (HGSOC) cell proliferation^[1].
Zilovertamab (50 μg/mL; 72 h) down-regulates ROR1 expression levels in CaOV3 at the transcriptional level^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

CaOV3, CaOV3CisR, PEO1, and PEO4 cells
Concentration:

25 and 50 µg/mL
Incubation Time:

72 hours
Result:

Reduced the proliferation of CaOV3, CaOV3CisR and PEO1.

Western Blot Analysis^[1]

Cell Line:

CaOV3, CaOV3CisR, PEO1, and PEO4 cells
Concentration:

50 µg/mL
Incubation Time:

72 hours
Result:

Down-regulated ROR1 expression levels in CaOV3 at the transcriptional level.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Gene ID

4919 [NCBI]

Accession

Q01973

Target

ROR1

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human IgG1 kappa

Application

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized Human ROR1-ECD-His can bind Zilovertamab. The EC₅₀ for this effect is 3.078 ng/mL.

Chemical Information

CAS No. 2485779-13-1
Appearance Liquid
Molecular Weight 145.12 kDa
Color Colorless to light yellow
SMILES

[Zilovertamab]
Synonyms

UC-961; Cirmtuzumab
Shipping

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Journal Impact Factor

Mol Ther

Development of a high-affinity anti-ROR1 variable region for broad anti-cancer immunotherapy. [Abstract]

2025 Dec 2:S1525-0016(25)00959-1. PMID: 41338184
Research Square Preprint

2024 Dec 02.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (260 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

References

[1]. Liu D, et, al. The Anti-ROR1 Monoclonal Antibody Zilovertamab Inhibits the Proliferation of Ovarian and Endometrial Cancer Cells. Pharmaceutics. 2022 Apr 11;14(4):837. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Clinical Trial
- Gene ID
- Accession
- Target
- Conjugated
- Reconsititution
- Format
- Application
- Biological Activity
Chemical Information
Publications (2)
Purity & Documentation
References

Product Name:
Cat. No.:
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MCE Japan Authorized Agent:

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Zilovertamab

Antibody Inhibitor Library

Publications Citing Use of MedChemExpress (MCE) Zilovertamab

All ROR Isoforms

All Wnt Isoforms

Biological Activity

Chemical Information

Publications (2)

Purity & Documentation

References

Calculators

Help & FAQs

Zilovertamab

Cell-ATP Viability Detection Kit

Protein A Agarose

HOLO Human Interleukin-2 (IL-2) Detection Kit

Bradford Protein Assay Kit

PBS Buffer (1×)

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

Antibody Inhibitor Library

Publications Citing Use of MedChemExpress (MCE) Zilovertamab

All ROR Isoforms

All Wnt Isoforms

Biological Activity

Chemical Information

Publications (2)

Purity & Documentation

References

Calculators

Help & FAQs

Zilovertamab Related Classifications

HY-P99201 Related Classifications