Wnt7

Wnt7 refers mainly to WNT7A and WNT7B, secreted Wnt ligands that regulate embryonic development, CNS angiogenesis, and blood-brain barrier formation^[1]^[2]. Mechanistically, WNT7A/B activate endothelial β-catenin signaling through GPR124-RECK-LRP5/6 receptor complexes, with WNT7 signaling showing isoform-selective dependence on RECK compared with WNT3A^[2]^[3]. In disease models, WNT7B drives autocrine Wnt/β-catenin signaling and anchorage-independent growth in pancreatic adenocarcinoma cells, while Wnt7a/7b deletion or pharmacologic Wnt inhibition blocks glioma vessel co-option and improves temozolomide response^[4]^[5]. Compared with related Wnt isoforms, WNT7A and WNT7B directly bind RECK, whereas WNT3A does not, supporting Wnt7-specific regulation of ligand bioavailability and endothelial signaling^[3]. For experimental applications, Wnt secretion inhibitors such as IWP-2 suppress ligand-dependent Wnt/β-catenin activity in PDAC cells, while FZD4-LRP5 agonists can induce a Norrin-like barrier transcriptional response in retinal models^[4]^[6].

References:

[1]. Beretta CA, et al. All four zebrafish Wnt7 genes are expressed during early brain development. Gene Expr Patterns. 2011 Mar-Apr;11(3-4):277-84. [Content Brief]

[2]. Heiden R, et al. WNT7A/B assemble a GPR124-RECK-LRP5/6 coreceptor complex to activate β-catenin signaling in brain endothelial cells. J Biol Chem. 2025 Oct;301(10):110682. [Content Brief]

[3]. Vallon M, et al. A RECK-WNT7 Receptor-Ligand Interaction Enables Isoform-Specific Regulation of Wnt Bioavailability. Cell Rep. 2018 Oct 9;25(2):339-349.e9. [Content Brief]

[4]. Arensman MD, et al. WNT7B mediates autocrine Wnt/β-catenin signaling and anchorage-independent growth in pancreatic adenocarcinoma. Oncogene. 2014 Feb 13;33(7):899-908. [Content Brief]

[5]. Griveau A, et al. A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment. Cancer Cell. 2018 May 14;33(5):874-889.e7. [Content Brief]

[6]. Zhang L, et al. A Frizzled4-LRP5 agonist promotes blood-retina barrier function by inducing a Norrin-like transcriptional response. iScience. 2023 Jul 18;26(8):107415. [Content Brief]

Wnt7 Inhibitors (2)

Wnt7 Related Products (2):

Cat. No.	Product Name	Effect	Purity

HY-D1474

WNT7A-IN-1 sodium	Inhibitor	98.05%
WNT7A-IN-1 sodium (1365-0109), a WNT7A inhibitor, disrupts the protein-protein interaction between WNT7A and its receptor FZD5, resulting in the upregulation of MHC-I expression. WNT7A-IN-1 sodium significantly increases the expression of MHC-I and p-p65,while concurrently reducing the expression of active β-catenin. WNT7A-IN-1 sodium (compound F) is also a photographic sensitizer in the green spectral region.

HY-170411

WNT7A-IN-1	Inhibitor	99.66%
WNT7A-IN-1 (1365-0109), a WNT7A inhibitor, disrupts the protein-protein interaction between WNT7A and its receptor FZD5, resulting in the upregulation of MHC-I expression. WNT7A-IN-1 significantly increases the expression of MHC-I and p-p65,while concurrently reducing the expression of active β-catenin. WNT7A-IN-1 (compound F) is also a photographic sensitizer in the green spectral region.

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