29133-39-9
Chemical Structure
WNT7A-IN-1
- CAS No.: 29133-39-9
- Formula:C37H36N2O8S2
- Molecular Weight:700.82
InChIKey: WBJFYAXVVHNETH-UHFFFAOYSA-N
SMILES: O=S([O-])(CCC[N+]1=C(/C=C(CC)/C=C2OC3=C(N\2CCCS(=O)(O)=O)C=C(C4=CC=CC=C4)C=C3)OC5=CC=C(C6=CC=CC=C6)C=C51)=O
Biological Activity: WNT7A-IN-1 (1365-0109), a WNT7A inhibitor, disrupts the protein-protein interaction between WNT7A and its receptor FZD5, resulting in the upregulation of MHC-I expression. WNT7A-IN-1 significantly increases the expression of MHC-I and p-p65,while concurrently reducing the expression of active β-catenin. WNT7A-IN-1 (compound F) is also a photographic sensitizer in the green spectral region[1][2].
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WNT7A-IN-1 | 99.66% | WNT7A-IN-1 (1365-0109), a WNT7A inhibitor, disrupts the protein-protein interaction between WNT7A and its receptor FZD5, resulting in the upregulation of MHC-I expression. WNT7A-IN-1 significantly increases the expression of MHC-I and p-p65,while concurrently reducing the expression of active β-catenin. WNT7A-IN-1 (compound F) is also a photographic sensitizer in the green spectral region. | ||||||||||||||||||||
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- [1]. Jiazheng Sun, et al. Blocking WNT7A Enhances MHC-I Antigen Presentation and Enhances the Effectiveness of Immune Checkpoint Blockade Therapy. Cancer Immunol Res. 2024 Nov 27. [Content Brief]
- [2]. I.Baraldi, et al. Dimerization of green sensitizing cyanines in solution. A spectroscopic and theoretical study of the bonding nature. Chemical Physics. Volume 275, Issues 1-3, 1 January 2002, Pages 149-165.
Keywords
