2. Stem Cell/Wnt
  3. Wnt
  4. WNT7A-IN-1 sodium

WNT7A-IN-1 sodium (1365-0109), a WNT7A inhibitor, disrupts the protein-protein interaction between WNT7A and its receptor FZD5, resulting in the upregulation of MHC-I expression. WNT7A-IN-1 sodium significantly increases the expression of MHC-I and p-p65,while concurrently reducing the expression of active β-catenin. WNT7A-IN-1 sodium (compound F) is also a photographic sensitizer in the green spectral region.

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WNT7A-IN-1 sodium

WNT7A-IN-1 sodium Chemical Structure

CAS No. : 33628-03-4

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WNT7A-IN-1 sodium Related Antibodies

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Description

WNT7A-IN-1 sodium (1365-0109), a WNT7A inhibitor, disrupts the protein-protein interaction between WNT7A and its receptor FZD5, resulting in the upregulation of MHC-I expression. WNT7A-IN-1 sodium significantly increases the expression of MHC-I and p-p65,while concurrently reducing the expression of active β-catenin[1]. WNT7A-IN-1 sodium (compound F) is also a photographic sensitizer in the green spectral region[2].

IC50 & Target

Wnt7A

 

Molecular Weight

722.80

Formula

C37H35N2NaO8S2
CAS No.
Appearance

Solid

Color

Orange to red

SMILES

O=S([O-])(CCC[N+]1=C(/C=C(CC)/C=C2OC3=C(N\2CCCS(=O)(O[Na])=O)C=C(C4=CC=CC=C4)C=C3)OC5=CC=C(C6=CC=CC=C6)C=C51)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (138.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3835 mL 6.9175 mL 13.8351 mL
5 mM 0.2767 mL 1.3835 mL 2.7670 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.05%

SDS (393 KB)

COA (253 KB) HNMR (392 KB) LCMS (89 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3835 mL 6.9175 mL 13.8351 mL 34.5877 mL
5 mM 0.2767 mL 1.3835 mL 2.7670 mL 6.9175 mL
10 mM 0.1384 mL 0.6918 mL 1.3835 mL 3.4588 mL
15 mM 0.0922 mL 0.4612 mL 0.9223 mL 2.3058 mL
20 mM 0.0692 mL 0.3459 mL 0.6918 mL 1.7294 mL
25 mM 0.0553 mL 0.2767 mL 0.5534 mL 1.3835 mL
30 mM 0.0461 mL 0.2306 mL 0.4612 mL 1.1529 mL
40 mM 0.0346 mL 0.1729 mL 0.3459 mL 0.8647 mL
50 mM 0.0277 mL 0.1384 mL 0.2767 mL 0.6918 mL
60 mM 0.0231 mL 0.1153 mL 0.2306 mL 0.5765 mL
80 mM 0.0173 mL 0.0865 mL 0.1729 mL 0.4323 mL
100 mM 0.0138 mL 0.0692 mL 0.1384 mL 0.3459 mL
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WNT7A-IN-1 sodium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WNT7A-IN-133628-03-4WntWNT7A inhibitorphotographic sensitizergreen spectral regionMHC-Ip-p65Inhibitorinhibitorinhibit

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