33628-03-4
Chemical Structure
WNT7A-IN-1 sodium
- CAS No.: 33628-03-4
- Formula:C37H35N2NaO8S2
- Molecular Weight:722.80
IUPAC Name: sodium 3-((Z)-5-phenyl-2-((E)-2-((5-phenyl-3-(3-sulfonatopropyl)benzo[d]oxazol-3-ium-2-yl)methylene)butylidene)benzo[d]oxazol-3(2H)-yl)propane-1-sulfonate
InChIKey: MDBAEQGNAMHPTI-UHFFFAOYSA-M
SMILES: O=S([O-])(CCC[N+]1=C(/C=C(CC)/C=C2OC3=C(N\2CCCS(=O)(O[Na])=O)C=C(C4=CC=CC=C4)C=C3)OC5=CC=C(C6=CC=CC=C6)C=C51)=O
Biological Activity: WNT7A-IN-1 sodium (1365-0109), a WNT7A inhibitor, disrupts the protein-protein interaction between WNT7A and its receptor FZD5, resulting in the upregulation of MHC-I expression. WNT7A-IN-1 sodium significantly increases the expression of MHC-I and p-p65,while concurrently reducing the expression of active β-catenin[1]. WNT7A-IN-1 sodium (compound F) is also a photographic sensitizer in the green spectral region[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
WNT7A-IN-1 sodium | 95.74% | WNT7A-IN-1 sodium (1365-0109), a WNT7A inhibitor, disrupts the protein-protein interaction between WNT7A and its receptor FZD5, resulting in the upregulation of MHC-I expression. WNT7A-IN-1 sodium significantly increases the expression of MHC-I and p-p65,while concurrently reducing the expression of active β-catenin. WNT7A-IN-1 sodium (compound F) is also a photographic sensitizer in the green spectral region. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Jiazheng Sun, et al. Blocking WNT7A Enhances MHC-I Antigen Presentation and Enhances the Effectiveness of Immune Checkpoint Blockade Therapy. Cancer Immunol Res. 2024 Nov 27. [Content Brief]
- [2]. I.Baraldi, et al. Dimerization of green sensitizing cyanines in solution. A spectroscopic and theoretical study of the bonding nature. Chemical Physics. Volume 275, Issues 1-3, 1 January 2002, Pages 149-165.
