RORγ

RORγ Related Products (20):

By Type:	Pan (1) Selective (15)
By Effects:	Inhibitors (7) Agonists (2) Antagonists (7) Activator (1) Modulators (3)

Cat. No.	Product Name	Effect	Purity

HY-120210

XY018	Antagonist	99.90%
XY018 is a potent ROR-γ-selective antagonist.

HY-19775

GNE-6468	Antagonist	99.50%
GNE-6468 is a highly potent and selective RORγ (RORc) inverse agonist with an EC₅₀ value of 13 nM for HEK-293 cell.

HY-103637A

Vimirogant hydrochloride	Inhibitor	98.33%
Vimirogant (VTP-43742) hydrochloride is a potent, selective, and orally active RORγt inhibitor (K_i=3.5 nM; IC₅₀=17 nM).

HY-119366

S18-000003	Inhibitor	99.26%
S18-000003 is a potent, selective and orally active inhibitor of retinoic acid receptor-related orphan receptor-gamma-t (RORγt), with an IC₅₀ of <30 nM towards human RORγt in competitive binding assays.

HY-131338

RORγt inverse agonist 13	Inhibitor	99.22%
RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist, with improved drug-like properties, with an IC₅₀ of 63.8 nM.

HY-138115

7ß,27-Dihydroxycholesterol	Activator
7ß,27-Dihydroxycholesterol (7β, 27-OHC) is a potent and selective activator of RORγt (K_i=120 nM).

HY-113345

Zymostenol	Agonist
Zymostenol (5a-Cholest-8-en-3b-ol) is a late-stage precursor in the biosynthesis of cholesterol.

HY-139780

JNJ-61803534	Inhibitor	99.88%
JNJ-61803534 is a potent and orally active RORγt inverse agonist with an IC₅₀ of 9.6 nM.

HY-133552

RORγt Inverse agonist 10	Antagonist	99.13%
RORγt Inverse agonist 10 is a potent and orally bioavailable RORγt (retinoic acid receptor-related orphan nuclear receptor gamma t) inverse agonist, with an IC₅₀ of 51 nM.

HY-136527

BMS-986251	Antagonist
BMS-986251 is an orally active and selective RORγt inverse agonist with an EC₅₀ of 12 nM for RORγt GAL4.

HY-126252

A-9758	Inhibitor
A-9758 is a RORγ ligand and a potent, selective RORγt inverse agonist (IC₅₀=5 nM), and exhibits robust potency against IL-17A release.

HY-115879

SHR168442	Modulator
SHR168442 is a modulator of retinoid-related orphan receptor gamma (RORγ) with an IC₅₀ value of 0.035 μM.

HY-142940

RORγt modulator 5	Modulator
RORγt modulator 5 is a RORγt modulator with a K_i value of <100 nM.

HY-120785

SR1555	Antagonist
SR1555 is a specific retinoic acid receptor-related orphan nuclear receptor γ (RORγ) inverse agonist with an IC₅₀ value of 1 μM.

HY-142939

RORγt modulator 4	Modulator
RORγt modulator 4 is a RORγt modulator.

HY-126037

(±)-ML 209	Antagonist
(±)-ML 209 (compound 4n), a diphenylpropanamide, is a retinoic acid-related orphan receptor RORγ antagonist with an IC₅₀ of 1.1 μM.

HY-143271

RORγt inverse agonist 29	Inhibitor
RORγt inverse agonist 29 is a potent, orally active and selective RORγt inverse agonist (IC₅₀: 21 nM).

HY-111366

CD12681	Agonist
CD12681 (compound 14) is a potent and selective RORγ inverse agonist with IC₅₀ of 19 nM and 10 nM for RORγ GAL4 and CD4-IL-17 cells, respectively.

HY-147533

RORγt inverse agonist 30	Antagonist
RORγt inverse agonist 30 (compound 1) is a potent retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist with an IC₅₀ value of 46 nM.

HY-103637

Vimirogant	Inhibitor
Vimirogant (VTP-43742) is a potent, selective, and orally active RORγt inhibitor (K_i=3.5 nM; IC₅₀=17 nM).

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