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  3. Vimirogant hydrochloride

Vimirogant hydrochloride (Synonyms: VTP-43742 hydrochloride)

Cat. No.: HY-103637A Purity: 98.33%
Handling Instructions

Vimirogant (VTP-43742) hydrochloride is a potent, selective, and orally active RORγt inhibitor (Ki=3.5 nM; IC50=17 nM). Vimirogant hydrochloride exhibits >1000-fold selectivity versus the RORα and RORβ isotypes. Vimirogant hydrochloride inhibits Th17 differentiation and IL-17A secretion from mouse splenocytes (IC50=57 nM) without affecting Th1, Th2, or Treg cell differentiation. Vimirogant hydrochloride has the potential for autoimmune disorders research.

For research use only. We do not sell to patients.

Vimirogant hydrochloride Chemical Structure

Vimirogant hydrochloride Chemical Structure

Size Price Stock Quantity
1 mg USD 795 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1750 In-stock
Estimated Time of Arrival: December 31
10 mg USD 2800 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Vimirogant (VTP-43742) hydrochloride is a potent, selective, and orally active RORγt inhibitor (Ki=3.5 nM; IC50=17 nM). Vimirogant hydrochloride exhibits >1000-fold selectivity versus the RORα and RORβ isotypes. Vimirogant hydrochloride inhibits Th17 differentiation and IL-17A secretion from mouse splenocytes (IC50=57 nM) without affecting Th1, Th2, or Treg cell differentiation. Vimirogant hydrochloride has the potential for autoimmune disorders research[1][2].

IC50 & Target[1]

RORγt

3.5 nM (Ki)

RORγt

17 nM (IC50)

In Vitro

Vimirogant hydrochloride inhibits the secretion of IL-17A from activated hPBMCs (IC50=18 nM) and human whole blood (IC50=192 nM)[1].

In Vivo

In the MOG35-55/CFA immunized mouse EAE model, Vimirogant hydrochloride (p.o.) significantly suppresses clinical symptoms, demyelination and mRNA expression of multiple inflammatory markers in the spinal cord[1].

Formula

C₂₇H₃₅F₃N₄O₃S.xHCl

SMILES

O=C(C1=CN=C([[email protected]](C(C)C)N(C[[email protected]]2CC[[email protected]](C(F)(F)F)CC2)C3)C3=C1)NCC4=NC=C(S(=O)(CC)=O)C=C4.Cl.[x]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (Need ultrasonic)

In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (Infinity mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 6.25 mg/mL (Infinity mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (Infinity mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

VimirogantVTP-43742VTP43742VTP 43742RORRAR-related orphan receptorinflammatorycytokineIL-17ATh17cellsautoimmunedisorderspsoriasisarthritisPBMCInhibitorinhibitorinhibit

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Product Name:
Vimirogant hydrochloride
Cat. No.:
HY-103637A
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